MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Non-cancer illness code self-reported: hypertension | 0.0143 | 0.00468 | 0.0022 | Wald ratio | 1 | cis | NA |
| Internalizing problems | 0.0773 | 0.026 | 0.00289 | Wald ratio | 1 | cis | NA |
| Forced vital capacity (FVC) | 0.00659 | 0.00229 | 0.00397 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: H25 Senile cataract | 0.0841 | 0.0292 | 0.00401 | Wald ratio | 1 | cis | NA |
| Body mass index (BMI) | -0.00748 | 0.00279 | 0.00723 | Wald ratio | 1 | cis | NA |
| Forced expiratory volume in 1-second (FEV1) | 0.00642 | 0.00241 | 0.00782 | Wald ratio | 1 | cis | NA |
| Bulimia nervosa | 0.0222 | 0.00847 | 0.00866 | Wald ratio | 1 | cis | NA |
| Systolic blood pressure automated reading | -0.00748 | 0.00285 | 0.00869 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I30 Acute pericarditis | 0.308 | 0.119 | 0.00932 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: D25 Leiomyoma of uterus | 0.0589 | 0.0232 | 0.0111 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I48 Atrial fibrillation and flutter | 0.0613 | 0.0248 | 0.0135 | Wald ratio | 1 | cis | NA |
| Alcohol intake frequency | -0.0101 | 0.00412 | 0.014 | Wald ratio | 1 | cis | NA |
| …and 93 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
41 association rows across 18 traits (39 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating ACP6 levels | 2e-4526 | rs28700004 | 3 | GCST90860337 | no MR -> candidate analysis |
| Lysophosphatidic acid phosphatase type 6 levels | 7e-1466 | rs2153463 | 6 | GCST90248244 | no MR -> candidate analysis |
| Cerebrospinal fluid protein ACP6 levels | 4e-407 | rs2153463 | 1 | GCST90942987 | no MR -> candidate analysis |
| Blood protein levels | 2e-312 | rs2153463 | 1 | GCST006585 | no MR -> candidate analysis |
| ACP6 protein levels | 2e-219 | rs150066520 | 13 | GCST90468204 | no MR -> candidate analysis |
| Serum levels of protein ACP6 | 7e-171 | rs75583687 | 2 | GCST90089187 | no MR -> candidate analysis |
| Lysophosphatidic acid phosphatase type 6 level in Chronic ki | 6e-78 | rs2153463 | 1 | GCST90238074 | no MR -> candidate analysis |
| Height | 2e-72 | rs12129752 | 1 | GCST90245848 | MR: beta=0.00773, p=0.0225 (cis) |
| X-24747 levels | 2e-63 | rs6674938 | 1 | GCST90103336 | no MR -> candidate analysis |
| X-24309 levels | 2e-41 | rs2153463 | 2 | GCST90245747 | no MR -> candidate analysis |
| Hemopexin protein levels (SomaScan ID:5742-14) | 3e-20 | rs1344 | 1 | GCST90438035 | no MR -> candidate analysis |
| Cerebrospinal fluid metabolite X-12411 levels | 2e-15 | rs2275552 | 1 | GCST90318302 | no MR -> candidate analysis |
| …and 6 more traits (see JSON) |
Top diseases by Open Targets association (of 59 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| ventricular septal defect | 0.538 | — | common-variant locus | no MR -> candidate analysis |
| dermatophytosis | 0.502 | — | common-variant locus | no MR -> candidate analysis |
| Rare genetic intellectual disability with developmental anomaly | 0.438 | — | established (curated) | no MR -> candidate analysis |
| gallbladder disorder | 0.393 | — | common-variant locus | no MR -> candidate analysis |
| response to anticoagulant | 0.309 | — | common-variant locus | no MR -> candidate analysis |
Of the 5 rows above, 5 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=8.3e-17, LOEUF=1.27 — LoF-tolerant |
| GWAS Catalog | 88 unique SNPs / 176 rows |
| ClinVar | 393 records; 12 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 59 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘ACP6’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 393 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 18 of 18 traits by best p-value, aggregated from 41 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9NPH0 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000162836/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/ACP6 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/ACP6 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=ACP6%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/ACP6 — GWAS Catalog search API (live; release not exposed)