MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Non-cancer illness code self-reported: high cholesterol | -0.243 | 0.0526 | 3.74e-06 | Wald ratio | 1 | trans | NA |
| Forced expiratory volume in 1-second (FEV1) | 0.051 | 0.0131 | 1.04e-04 | Wald ratio | 1 | trans | NA |
| Forced vital capacity (FVC) | 0.0445 | 0.0125 | 3.57e-04 | Wald ratio | 1 | trans | NA |
| Systolic blood pressure automated reading | -0.0511 | 0.0155 | 0.00102 | Wald ratio | 1 | trans | NA |
| Body mass index (BMI) | -0.0449 | 0.0152 | 0.00313 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: I48 Atrial fibrillation and flutter | 0.276 | 0.111 | 0.0127 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: hypertension | -0.069 | 0.0278 | 0.0131 | Wald ratio | 1 | trans | NA |
| Bulimia nervosa | -0.106 | 0.0437 | 0.0152 | Wald ratio | 1 | trans | NA |
| Endometrioid ovarian cancer | -0.454 | 0.188 | 0.0158 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: R10 Abdominal and pelvic pain | -0.224 | 0.0928 | 0.0159 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: psoriasis | 0.252 | 0.113 | 0.0255 | Wald ratio | 1 | trans | NA |
| Lumbar spine bone mineral density | -0.119 | 0.0555 | 0.0313 | Wald ratio | 1 | trans | NA |
| …and 63 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
102 association rows across 76 traits (97 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating ADAM15 levels | 4e-3324 | rs11589479 | 6 | GCST90860707 | no MR -> candidate analysis |
| Disintegrin and metalloproteinase domain-containing protein | 2e-207 | rs11589479 | 2 | GCST90059897 | no MR -> candidate analysis |
| Cerebrospinal fluid protein ADAM15 levels | 9e-120 | rs41264285 | 1 | GCST90942994 | no MR -> candidate analysis |
| Vertex-wise sulcal depth | 6e-78 | rs11589479 | 1 | GCST90095129 | no MR -> candidate analysis |
| ADAM15 protein levels | 4e-55 | rs114498585 | 3 | GCST90468217 | no MR -> candidate analysis |
| Albumin levels | 2e-50 | rs11589479 | 8 | GCST90662901 | no MR -> candidate analysis |
| Sushi, von Willebrand factor type A, EGF and pentraxin domai | 2e-49 | rs45444697 | 1 | GCST90249743 | no MR -> candidate analysis |
| Serum albumin levels | 2e-42 | rs11589479 | 2 | GCST90018945 | no MR -> candidate analysis |
| hematocrit (mean, inv-norm transformed) | 3e-34 | rs6660884 | 1 | GCST90475341 | no MR -> candidate analysis |
| Urea levels | 1e-32 | rs6427128 | 1 | GCST90019525 | no MR -> candidate analysis |
| hemoglobin (maximum, inv-norm transformed) | 2e-32 | rs6660884 | 1 | GCST90475372 | no MR -> candidate analysis |
| Height | 4e-32 | rs2306125 | 1 | GCST90245848 | no MR -> candidate analysis |
| …and 64 more traits (see JSON) |
Top diseases by Open Targets association (of 452 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Varicose veins | 0.652 | — | common-variant locus | no MR -> candidate analysis |
| open-angle glaucoma | 0.623 | — | common-variant locus | no MR -> candidate analysis |
| substance abuse | 0.49 | — | common-variant locus | no MR -> candidate analysis |
| attention deficit-hyperactivity disorder | 0.49 | — | common-variant locus | no MR -> candidate analysis |
| lymphatic system disorder | 0.458 | — | common-variant locus | no MR -> candidate analysis |
| vein disorder | 0.458 | — | common-variant locus | no MR -> candidate analysis |
| actinic keratosis | 0.458 | — | common-variant locus | no MR -> candidate analysis |
| kidney failure | 0.417 | — | common-variant locus | no MR -> candidate analysis |
| COVID-19 | 0.373 | — | common-variant locus | no MR -> candidate analysis |
| systemic lupus erythematosus | 0.366 | — | common-variant locus | no MR -> candidate analysis |
| prostate carcinoma | 0.257 | — | common-variant locus | no MR -> candidate analysis |
| metabolic dysfunction-associated steatotic liver disease | 0.134 | — | common-variant locus | no MR -> candidate analysis |
| bladder exstrophy | 0.132 | — | common-variant locus | no MR -> candidate analysis |
| obesity disorder | 0.123 | — | common-variant locus | no MR -> candidate analysis |
Of the 14 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Disintegrin and metalloproteinase domain-containing protein 15) |
| gnomAD constraint | pLI=2.2e-17, LOEUF=0.818 — LoF-tolerant |
| GWAS Catalog | 138 unique SNPs / 334 rows |
| ClinVar | 224 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 452 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘ADAM15’ and resolved to ‘Disintegrin and metalloproteinase domain-containing protein 15’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 224 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 76 traits by best p-value, aggregated from 102 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q13444 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000143537/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2331050/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/ADAM15 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/ADAM15 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=ADAM15%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/ADAM15 — GWAS Catalog search API (live; release not exposed)