MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Forced expiratory volume in 1-second (FEV1) | 0.0682 | 0.00892 | 2.10e-14 | Wald ratio | 1 | cis | NA |
| Height | 0.0488 | 0.0126 | 1.08e-04 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: asthma | -0.126 | 0.0328 | 1.21e-04 | Wald ratio | 1 | cis | NA |
| Hippocampus volume | 63.7 | 20 | 0.00148 | Wald ratio | 1 | cis | NA |
| Forced vital capacity (FVC) | 0.0245 | 0.00846 | 0.00371 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R10 Abdominal and pelvic pain | -0.157 | 0.0585 | 0.00714 | Wald ratio | 1 | cis | NA |
| Intracranial volume | 1.99e+04 | 8.17e+03 | 0.015 | Wald ratio | 1 | cis | NA |
| Neo-conscientiousness | -0.748 | 0.312 | 0.0166 | Wald ratio | 1 | cis | NA |
| Subjective well being | 0.0285 | 0.0122 | 0.0196 | Wald ratio | 1 | cis | NA |
| Invasive mucinous ovarian cancer | 0.396 | 0.173 | 0.0218 | Wald ratio | 1 | cis | NA |
| HDL cholesterol | -0.0419 | 0.0199 | 0.0355 | Wald ratio | 1 | cis | NA |
| Paget’s disease | -0.524 | 0.249 | 0.0356 | Wald ratio | 1 | cis | NA |
| …and 109 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
91 association rows across 69 traits (81 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Lung function (FEV1/FVC) | 3e-91 | rs11134789 | 6 | GCST007080 | no MR -> candidate analysis |
| FEV1/FVC ratio | 7e-75 | rs4331881 | 1 | GCST90705072 | no MR -> candidate analysis |
| FEV1 FVC ratio Z score (UKB data field 20258) | 1e-69 | rs112325689 | 1 | GCST90468165 | no MR -> candidate analysis |
| HAVCR1 protein levels | 4e-58 | rs11466764 | 1 | GCST90469431 | no MR -> candidate analysis |
| Chronic obstructive pulmonary disease liability (machine lea | 2e-50 | rs1990950 | 1 | GCST90244098 | no MR -> candidate analysis |
| Serum levels of protein ADAM19 | 1e-33 | rs7728609 | 1 | GCST90090399 | no MR -> candidate analysis |
| Forced expiratory volume in 1 second (FEV1) | 6e-27 | rs13361953 | 1 | GCST90705070 | no MR -> candidate analysis |
| Peak expiratory flow | 5e-25 | rs11134789 | 3 | GCST007430 | no MR -> candidate analysis |
| FEV1 | 6e-25 | rs11134789 | 3 | GCST007432 | MR: beta=0.0682, p=2.10e-14 (cis) |
| Hematological traits (multi-trait analysis) | 3e-23 | rs34197759 | 1 | GCST90838669 | no MR -> candidate analysis |
| Blood protein levels | 1e-21 | rs7728609 | 1 | GCST006585 | no MR -> candidate analysis |
| Forced expiratory volume in 1 second FEV1 Z score (UKB data | 3e-21 | rs11134789 | 1 | GCST90468166 | no MR -> candidate analysis |
| …and 57 more traits (see JSON) |
Top diseases by Open Targets association (of 1018 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| coronary artery disorder | 0.695 | — | common-variant locus | no MR -> candidate analysis |
| asthma | 0.661 | — | common-variant locus | MR: beta=-0.126, p=1.21e-04 (cis) |
| chronic obstructive pulmonary disease | 0.661 | — | common-variant locus | no MR -> candidate analysis |
| coronary atherosclerosis | 0.534 | — | common-variant locus | no MR -> candidate analysis |
| cholelithiasis | 0.403 | — | common-variant locus | MR: beta=-0.177, p=0.0409 (cis) |
| non-autoimmune hemolytic anemia | 0.393 | — | common-variant locus | no MR -> candidate analysis |
| gastroesophageal reflux disease | 0.351 | — | common-variant locus | no MR -> candidate analysis |
| lower respiratory tract disorder | 0.239 | — | common-variant locus | no MR -> candidate analysis |
| Chronic Obstructive Asthma | 0.226 | — | common-variant locus | no MR -> candidate analysis |
Of the 9 rows above, 7 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=8.8e-11, LOEUF=0.696 — LoF-tolerant |
| GWAS Catalog | 89 unique SNPs / 151 rows |
| ClinVar | 181 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 1018 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘ADAM19’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 181 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 69 traits by best p-value, aggregated from 91 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9H013 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000135074/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/ADAM19 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/ADAM19 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=ADAM19%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/ADAM19 — GWAS Catalog search API (live; release not exposed)