MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Schizophrenia | -0.25 | 0.0599 | 3.05e-05 | Wald ratio | 1 | cis | NA |
| Alcohol intake frequency | -0.0598 | 0.0201 | 0.00294 | Wald ratio | 1 | cis | NA |
| Clear cell ovarian cancer | -0.595 | 0.227 | 0.00874 | Wald ratio | 1 | cis | NA |
| Happiness | -0.0428 | 0.0168 | 0.0109 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: retinal detachment | 0.382 | 0.167 | 0.0221 | Wald ratio | 1 | cis | NA |
| PGC cross-disorder traits | -0.164 | 0.0729 | 0.0245 | Wald ratio | 1 | cis | NA |
| Femoral neck bone mineral density | 0.0876 | 0.0425 | 0.0392 | Wald ratio | 1 | cis | NA |
| Neuroticism | -0.0339 | 0.0169 | 0.0455 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K20 Oesophagitis | 0.223 | 0.111 | 0.0456 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: pulmonary embolism (with or without) dvt | 0.235 | 0.121 | 0.0522 | Wald ratio | 1 | cis | NA |
| Knee and hip osteoarthritis | -0.231 | 0.119 | 0.0525 | Wald ratio | 1 | cis | NA |
| Body mass index (BMI) | -0.026 | 0.0136 | 0.0559 | Wald ratio | 1 | cis | NA |
| …and 60 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
37 association rows across 19 traits (25 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| ADAM22/EPHB6 protein level ratio | 2e-2411 | rs2279542 | 1 | GCST90313168 | no MR -> candidate analysis |
| Circulating ADAM22 levels | 8e-762 | rs10952901 | 6 | GCST90859681 | no MR -> candidate analysis |
| ADAM22 protein levels | 3e-114 | rs140448385 | 8 | GCST90468218 | no MR -> candidate analysis |
| Disintegrin and metalloproteinase domain-containing protein | 4e-70 | rs2279542 | 4 | GCST90247307 | no MR -> candidate analysis |
| Serum levels of protein ADAM22 | 6e-17 | rs2279542 | 2 | GCST90089934 | no MR -> candidate analysis |
| Aspartate aminotransferase to alanine aminotransferase ratio | 6e-10 | rs73200363 | 1 | GCST90019498 | no MR -> candidate analysis |
| Educational attainment | 9e-10 | rs1637492 | 1 | GCST90105038 | no MR -> candidate analysis |
| Height | 3e-8 | rs73202341 | 3 | GCST008904 | no MR -> candidate analysis |
| RBC levels of Phe (uM) | 3e-8 | rs111428945 | 1 | GCST90267513 | no MR -> candidate analysis |
| Color vision defects (Tritan) | 7e-8 | rs74349663 | 1 | GCST90301671 | no MR -> candidate analysis |
| TestASV_38 (Ruminococcus) prevalence | 1e-6 | rs3761806 | 1 | GCST90011713 | no MR -> candidate analysis |
| Metabolite levels | 4e-6 | rs1201841 | 1 | GCST009391 | no MR -> candidate analysis |
| …and 7 more traits (see JSON) |
Top diseases by Open Targets association (of 424 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| developmental and epileptic encephalopathy, 61 | 0.8 | — | established (curated) | no MR -> candidate analysis |
| cholelithiasis | 0.585 | — | common-variant locus | no MR -> candidate analysis |
| vertebral column disorder | 0.4 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the immune system | 0.4 | — | common-variant locus | no MR -> candidate analysis |
| hereditary disease | 0.318 | — | established (curated) | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.305 | — | common-variant locus | no MR -> candidate analysis |
| Respiratory insufficiency | 0.302 | — | common-variant locus | no MR -> candidate analysis |
| Subdural hemorrhage | 0.299 | — | common-variant locus | no MR -> candidate analysis |
| Intrahepatic cholestasis of pregnancy | 0.139 | — | common-variant locus | no MR -> candidate analysis |
Of the 9 rows above, 9 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.00026, LOEUF=0.553 — LoF-tolerant |
| GWAS Catalog | 44 unique SNPs / 88 rows |
| ClinVar | 214 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 424 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘ADAM22’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 214 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 19 of 19 traits by best p-value, aggregated from 37 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9P0K1 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000008277/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/ADAM22 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/ADAM22 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=ADAM22%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/ADAM22 — GWAS Catalog search API (live; release not exposed)