MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Diagnoses - main ICD10: K80 Cholelithiasis | -0.129 | 0.0476 | 0.00675 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: vitiligo | 0.558 | 0.22 | 0.0112 | Wald ratio | 1 | cis | NA |
| Knee osteoarthritis | 0.168 | 0.0695 | 0.0157 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K57 Diverticular disease of intestine | -0.113 | 0.0473 | 0.0172 | Wald ratio | 1 | cis | NA |
| Birth weight | 0.0211 | 0.00903 | 0.0196 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: G56 Mononeuropathies of upper limb | 0.0949 | 0.0415 | 0.0223 | Wald ratio | 1 | cis | NA |
| HbA1C | -0.0187 | 0.00879 | 0.033 | Wald ratio | 1 | cis | NA |
| Alzheimer’s disease | -0.0773 | 0.0393 | 0.0494 | Wald ratio | 1 | cis | NA |
| Eczema | -0.0816 | 0.0421 | 0.0528 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K40 Inguinal hernia | 0.065 | 0.0344 | 0.0584 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: anxiety or panic attacks | 0.0876 | 0.0474 | 0.0645 | Wald ratio | 1 | cis | NA |
| Height | 0.0141 | 0.00764 | 0.0645 | Wald ratio | 1 | cis | NA |
| …and 102 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
56 association rows across 26 traits (51 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating ADAM23 levels | 7e-1768 | rs1448903 | 8 | GCST90859683 | no MR -> candidate analysis |
| ADAM23/BSG protein level ratio | 8e-1698 | rs1448903 | 1 | GCST90313169 | no MR -> candidate analysis |
| ADAM23 protein levels | 4e-286 | rs74668856 | 8 | GCST90468219 | no MR -> candidate analysis |
| Disintegrin and metalloproteinase domain-containing protein | 6e-174 | rs1207146 | 7 | GCST90247308 | no MR -> candidate analysis |
| Disintegrin and metalloproteinase domain-containing protein | 3e-64 | rs1921673 | 4 | GCST90240922 | no MR -> candidate analysis |
| Serum levels of protein ADAM23 | 8e-63 | rs1448903 | 3 | GCST90089632 | no MR -> candidate analysis |
| Blood protein levels | 2e-40 | rs1448903 | 1 | GCST006585 | no MR -> candidate analysis |
| Childhood body mass index | 9e-23 | rs143223375 | 2 | GCST90301649 | no MR -> candidate analysis |
| ICD10 J35: Chronic diseases of tonsils and adenoids | 1e-20 | rs189411872 | 1 | GCST90269775 | no MR -> candidate analysis |
| Neurological blood protein biomarker levels | 3e-17 | rs1448903 | 2 | GCST008478 | no MR -> candidate analysis |
| Pharyngeal disease | 3e-15 | rs189411872 | 1 | GCST90269785 | no MR -> candidate analysis |
| Chronic diseases of tonsils or adenoids (MTAG) | 1e-13 | rs189411872 | 1 | GCST90269792 | no MR -> candidate analysis |
| …and 14 more traits (see JSON) |
Top diseases by Open Targets association (of 917 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| tonsillitis | 0.551 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.458 | — | common-variant locus | no MR -> candidate analysis |
| disorder of pharynx | 0.441 | — | common-variant locus | no MR -> candidate analysis |
| lymphatic system disorder | 0.43 | — | common-variant locus | no MR -> candidate analysis |
| upper respiratory tract disorder | 0.43 | — | common-variant locus | no MR -> candidate analysis |
| cirrhosis of liver | 0.425 | — | common-variant locus | no MR -> candidate analysis |
| biliary tract disorder | 0.418 | — | common-variant locus | no MR -> candidate analysis |
| ovarian dysfunction | 0.394 | — | common-variant locus | no MR -> candidate analysis |
| retinal edema | 0.36 | — | common-variant locus | no MR -> candidate analysis |
| sialadenitis | 0.35 | — | common-variant locus | no MR -> candidate analysis |
| cervical carcinoma | 0.35 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.244 | — | common-variant locus | no MR -> candidate analysis |
| obesity disorder | 0.182 | — | common-variant locus | no MR -> candidate analysis |
Of the 13 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=1, LOEUF=0.368 — LoF-INTOLERANT |
| GWAS Catalog | 60 unique SNPs / 120 rows |
| ClinVar | 147 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 917 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘ADAM23’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 147 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 26 traits by best p-value, aggregated from 56 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/O75077 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000114948/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/ADAM23 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/ADAM23 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=ADAM23%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/ADAM23 — GWAS Catalog search API (live; release not exposed)