MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| HOMA-IR | 0.0634 | 0.0158 | 6.33e-05 | Wald ratio | 1 | cis | NA |
| Platelet count | -6.06 | 1.55 | 9.60e-05 | Wald ratio | 1 | cis | NA |
| Fasting insulin | 0.0387 | 0.0127 | 0.00225 | Wald ratio | 1 | cis | NA |
| HDL cholesterol | 0.056 | 0.0187 | 0.0027 | Wald ratio | 1 | cis | NA |
| Forced expiratory volume in 1-second (FEV1) | -0.0224 | 0.00825 | 0.00653 | Wald ratio | 1 | cis | NA |
| Forced vital capacity (FVC) | -0.0212 | 0.00782 | 0.00677 | Wald ratio | 1 | cis | NA |
| Autism | -0.287 | 0.111 | 0.00937 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K57 Diverticular disease of intestine | 0.149 | 0.058 | 0.0104 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R14 Flatulence and related conditions | 0.594 | 0.234 | 0.011 | Wald ratio | 1 | cis | NA |
| Age at menopause | -0.176 | 0.0704 | 0.0124 | Wald ratio | 1 | cis | NA |
| Total cholesterol | -0.0475 | 0.0201 | 0.0179 | Wald ratio | 1 | cis | NA |
| Eye problems or disorders: Glaucoma | 0.158 | 0.0681 | 0.0206 | Wald ratio | 1 | cis | NA |
| …and 106 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
161 association rows across 121 traits (141 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| ADH4/GSTA1 protein level ratio | 1e-271 | rs2602836 | 1 | GCST90313191 | no MR -> candidate analysis |
| Drinks per week | 4e-259 | rs29001570 | 1 | GCST90243984 | no MR -> candidate analysis |
| ACY1/ADH4 protein level ratio | 2e-191 | rs2602836 | 1 | GCST90313161 | no MR -> candidate analysis |
| ADH4/DCXR protein level ratio | 2e-189 | rs2602836 | 1 | GCST90313190 | no MR -> candidate analysis |
| ADH4/KRT18 protein level ratio | 7e-164 | rs2602836 | 1 | GCST90313192 | no MR -> candidate analysis |
| ADH4/SCLY protein level ratio | 3e-156 | rs2602836 | 1 | GCST90313195 | no MR -> candidate analysis |
| ADH4/RBP5 protein level ratio | 3e-149 | rs2602836 | 1 | GCST90313194 | no MR -> candidate analysis |
| ADH4/C19orf12 protein level ratio | 4e-142 | rs2602836 | 1 | GCST90313188 | no MR -> candidate analysis |
| ADH4/SORD protein level ratio | 2e-133 | rs2602836 | 1 | GCST90313196 | no MR -> candidate analysis |
| ADH4/KYNU protein level ratio | 5e-128 | rs2602836 | 1 | GCST90313193 | no MR -> candidate analysis |
| ADH4/CA5A protein level ratio | 3e-117 | rs2602836 | 1 | GCST90313189 | no MR -> candidate analysis |
| Alcohol dehydrogenase class-3 levels | 3e-73 | rs62325239 | 1 | GCST90246435 | no MR -> candidate analysis |
| …and 109 more traits (see JSON) |
Top diseases by Open Targets association (of 249 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| AMED syndrome, digenic | 0.764 | — | established (curated) | no MR -> candidate analysis |
| Alzheimer disease | 0.452 | — | common-variant locus | no MR -> candidate analysis |
| gout | 0.387 | — | common-variant locus | MR: beta=0.146, p=0.0359 (cis) |
| ischemic stroke | 0.205 | — | common-variant locus | no MR -> candidate analysis |
| coronary artery disorder | 0.193 | — | common-variant locus | no MR -> candidate analysis |
| substance-related disorder | 0.178 | — | common-variant locus | no MR -> candidate analysis |
| Parkinson disease | 0.152 | 0.152 | exploratory rare-variant signal | no MR -> candidate analysis |
| venous thromboembolism | 0.144 | — | common-variant locus | no MR -> candidate analysis |
| alcohol abuse | 0.078 | — | common-variant locus | no MR -> candidate analysis |
Of the 9 rows above, 8 have no MR estimate in this resource. Across all retrieved diseases for this gene: 1 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 2 known modulators (Alcohol dehydrogenase class-3) |
| gnomAD constraint | pLI=2.3e-09, LOEUF=1.07 — LoF-tolerant |
| GWAS Catalog | 111 unique SNPs / 252 rows |
| ClinVar | 76 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 249 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘ADH5’ and resolved to ‘Alcohol dehydrogenase class-3’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 76 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 121 traits by best p-value, aggregated from 161 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P11766 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000197894/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4116/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/ADH5 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/ADH5 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=ADH5%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/ADH5 — GWAS Catalog search API (live; release not exposed)