Protein Dossier — ADIPOQ (Adiponectin)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: pulmonary embolism (with or without) dvt |
0.448 |
0.128 |
4.42e-04 |
Wald ratio |
1 |
cis |
NA |
| Invasive mucinous ovarian cancer |
-0.874 |
0.261 |
8.14e-04 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I80 Phlebitis and thrombophlebitis |
0.46 |
0.169 |
0.00649 |
Wald ratio |
1 |
cis |
NA |
| Heel bone mineral density (BMD) T-score automated |
-0.0564 |
0.0227 |
0.013 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N92 Excessive frequent and irregular menstruation |
0.237 |
0.0982 |
0.0157 |
Wald ratio |
1 |
cis |
NA |
| Cancer code self-reported: malignant melanoma |
0.33 |
0.148 |
0.026 |
Wald ratio |
1 |
cis |
NA |
| Cancer code self-reported: prostate cancer |
0.326 |
0.154 |
0.034 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: diverticular disease or diverticulitis |
0.274 |
0.13 |
0.0345 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R10 Abdominal and pelvic pain |
0.155 |
0.0735 |
0.0351 |
Wald ratio |
1 |
cis |
NA |
| Caudate volume |
-67.2 |
32.9 |
0.041 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: asthma |
0.0912 |
0.0453 |
0.0439 |
Wald ratio |
1 |
cis |
NA |
| Primary sclerosing cholangitis |
-0.405 |
0.202 |
0.0452 |
Wald ratio |
1 |
cis |
NA |
| …and 53 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3554_24_1 |
Adiponectin |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
69 association rows across 34 traits (60 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| ADIPOQ protein levels |
4e-232 |
rs562177400 |
5 |
GCST90468245 |
no MR -> candidate analysis |
| Adiponectin levels |
5e-149 |
rs17366568 |
20 |
GCST010050 |
no MR -> candidate analysis |
| Adiponectin levels (BMI-adjusted) |
8e-55 |
rs199938283 |
6 |
GCST90011881 |
no MR -> candidate analysis |
| Circulating CD163 levels |
8e-32 |
rs9860747 |
1 |
GCST90859926 |
no MR -> candidate analysis |
| Kininogen-1 levels |
4e-30 |
rs17366568 |
1 |
GCST90162099 |
no MR -> candidate analysis |
| HEPACAM2 protein levels |
3e-29 |
rs9835223 |
2 |
GCST90469445 |
no MR -> candidate analysis |
| F11 protein levels |
4e-29 |
rs66471222 |
3 |
GCST90469165 |
no MR -> candidate analysis |
| CD163 protein levels |
5e-24 |
rs11923060 |
1 |
GCST90468600 |
no MR -> candidate analysis |
| Circulating LIFR levels |
1e-22 |
rs9860747 |
1 |
GCST90859867 |
no MR -> candidate analysis |
| Serum levels of protein ADIPOQ |
3e-22 |
rs143257534 |
1 |
GCST90088439 |
no MR -> candidate analysis |
| ST6GAL1 protein levels |
9e-22 |
rs4686807 |
1 |
GCST90470753 |
no MR -> candidate analysis |
| LIFR protein levels |
2e-20 |
rs9860747 |
1 |
GCST90469769 |
no MR -> candidate analysis |
| …and 22 more traits (see JSON) |
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|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 1595 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| adiponectin deficiency |
0.718 |
— |
established (curated) |
no MR -> candidate analysis |
| hearing loss disorder |
0.426 |
— |
common-variant locus |
no MR -> candidate analysis |
| hyperpituitarism |
0.315 |
— |
common-variant locus |
no MR -> candidate analysis |
| glomerulonephritis |
0.241 |
— |
common-variant locus |
no MR -> candidate analysis |
| diabetes mellitus |
0.034 |
— |
common-variant locus |
no MR -> candidate analysis |
| breast cancer |
0.032 |
— |
common-variant locus |
MR: beta=0.0812, p=0.343 (cis) |
Of the 6 rows above, 5 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Adiponectin receptor protein 2) |
| gnomAD constraint |
pLI=4.3e-08, LOEUF=1.73 — LoF-tolerant |
| GWAS Catalog |
116 unique SNPs / 282 rows |
| ClinVar |
87 records; 5 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
1 clinical annotations across 1 drugs |
phenome — Top 30 of 1595 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘ADIPOQ’ and resolved to ‘Adiponectin receptor protein 2’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 87 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 34 traits by best p-value, aggregated from 69 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q15848 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000181092/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3392947/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/ADIPOQ — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/ADIPOQ — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=ADIPOQ%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=ADIPOQ — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/ADIPOQ — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T00:56:29 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none