MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Eye problems or disorders: Glaucoma | 0.00798 | 0.00263 | 0.00242 | Inverse variance weighted | 2 | cis | NA |
| Eye problems or disorders: Glaucoma | 0.00798 | 0.00263 | 0.00242 | Inverse variance weighted | 2 | trans | NA |
| Forearm bone mineral density | 0.134 | 0.0534 | 0.012 | Inverse variance weighted | 2 | cis | NA |
| Forearm bone mineral density | 0.134 | 0.0534 | 0.012 | Inverse variance weighted | 2 | trans | NA |
| Eye problems or disorders: Cataract | 0.00987 | 0.00421 | 0.0189 | Inverse variance weighted | 2 | cis | NA |
| Eye problems or disorders: Cataract | 0.00987 | 0.00421 | 0.0189 | Inverse variance weighted | 2 | trans | NA |
| Hearing difficulty or problems: Yes | -0.00753 | 0.00327 | 0.0212 | Inverse variance weighted | 2 | cis | NA |
| Hearing difficulty or problems: Yes | -0.00753 | 0.00327 | 0.0212 | Inverse variance weighted | 2 | trans | NA |
| Diagnoses - main ICD10: R35 Polyuria | -0.00106 | 0.000463 | 0.0219 | Inverse variance weighted | 2 | cis | NA |
| Diagnoses - main ICD10: R35 Polyuria | -0.00106 | 0.000463 | 0.0219 | Inverse variance weighted | 2 | trans | NA |
| Serum cystatin C (eGFRcys) | 0.0137 | 0.00658 | 0.0379 | Inverse variance weighted | 2 | cis | NA |
| Serum cystatin C (eGFRcys) | 0.0137 | 0.00658 | 0.0379 | Inverse variance weighted | 2 | trans | NA |
| …and 181 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
28 association rows across 28 traits (26 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating ADM levels | 2e-162 | rs4641466 | 1 | GCST90859743 | no MR -> candidate analysis |
| Cholesteryl Esters in Small HDL | 1e-50 | rs56776911 | 1 | GCST90501236 | no MR -> candidate analysis |
| Cholesterol in Small HDL | 2e-41 | rs56776911 | 1 | GCST90501234 | no MR -> candidate analysis |
| Total lipids in small HDL | 8e-31 | rs56776911 | 1 | GCST90501240 | no MR -> candidate analysis |
| Phospholipids in small HDL | 5e-29 | rs56776911 | 1 | GCST90501242 | no MR -> candidate analysis |
| Phospholipids to Total Lipids in IDL percentage | 1e-26 | rs57153895 | 1 | GCST90501130 | no MR -> candidate analysis |
| Cholesteryl Esters in Medium HDL | 3e-23 | rs57153895 | 1 | GCST90501184 | no MR -> candidate analysis |
| Concentration of HDL particles | 6e-23 | rs57153895 | 1 | GCST90501116 | no MR -> candidate analysis |
| Cholesterol in Medium HDL | 4e-21 | rs57153895 | 1 | GCST90501182 | no MR -> candidate analysis |
| Total lipids in medium HDL | 5e-19 | rs57153895 | 1 | GCST90501188 | no MR -> candidate analysis |
| Concentration of medium HDL particles | 3e-18 | rs57153895 | 1 | GCST90501189 | no MR -> candidate analysis |
| Phospholipids in medium HDL | 6e-18 | rs57153895 | 1 | GCST90501190 | no MR -> candidate analysis |
| …and 16 more traits (see JSON) |
Top diseases by Open Targets association (of 1102 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| hypertensive disorder | 0.656 | — | common-variant locus | no MR -> candidate analysis |
| Varicose veins | 0.613 | — | common-variant locus | no MR -> candidate analysis |
| hemorrhoid | 0.505 | — | common-variant locus | no MR -> candidate analysis |
| cardiovascular disorder | 0.46 | — | common-variant locus | no MR -> candidate analysis |
| heart disorder | 0.452 | — | common-variant locus | no MR -> candidate analysis |
| Increased blood pressure | 0.44 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.4 | — | common-variant locus | no MR -> candidate analysis |
| lymphatic system disorder | 0.374 | — | common-variant locus | no MR -> candidate analysis |
| vein disorder | 0.374 | — | common-variant locus | no MR -> candidate analysis |
| atrial fibrillation | 0.338 | — | common-variant locus | no MR -> candidate analysis |
| congestive heart failure | 0.286 | — | common-variant locus | no MR -> candidate analysis |
| preeclampsia | 0.237 | — | common-variant locus | no MR -> candidate analysis |
| vascular disorder | 0.246 | — | common-variant locus | no MR -> candidate analysis |
| osteoarthritis, knee | 0.24 | — | common-variant locus | no MR -> candidate analysis |
| prolapse of female genital organ | 0.24 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 1 known modulators (Pro-adrenomedullin) |
| gnomAD constraint | pLI=0.24, LOEUF=1.02 — LoF-tolerant |
| GWAS Catalog | 104 unique SNPs / 256 rows |
| ClinVar | 46 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | 1 clinical annotations across 1 drugs |
phenome — Top 30 of 1102 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘ADM’ and resolved to ‘Pro-adrenomedullin’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 46 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 28 traits by best p-value, aggregated from 28 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P35318 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000148926/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2062356/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/ADM — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/ADM — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=ADM%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=ADM — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/ADM — GWAS Catalog search API (live; release not exposed)