Protein Dossier — AGT (Angiotensinogen)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Diastolic blood pressure automated reading |
0.0608 |
0.00894 |
1.04e-11 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypertension |
0.0846 |
0.0137 |
6.52e-10 |
Wald ratio |
1 |
cis |
NA |
| Systolic blood pressure automated reading |
0.0524 |
0.00894 |
4.70e-09 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level |
0.729 |
0.211 |
5.64e-04 |
Wald ratio |
1 |
cis |
NA |
| Coronary heart disease |
0.0941 |
0.0306 |
0.0021 |
Wald ratio |
1 |
cis |
NA |
| Myocardial infarction |
0.0926 |
0.0339 |
0.00622 |
Wald ratio |
1 |
cis |
NA |
| Systemic lupus erythematosus |
-0.442 |
0.163 |
0.00657 |
Wald ratio |
1 |
cis |
NA |
| Forced expiratory volume in 1-second (FEV1) |
0.0202 |
0.00756 |
0.00745 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N92 Excessive frequent and irregular menstruation |
0.13 |
0.0536 |
0.0152 |
Wald ratio |
1 |
cis |
NA |
| Hearing difficulty or problems: Yes |
0.0351 |
0.0146 |
0.0158 |
Wald ratio |
1 |
cis |
NA |
| Anorexia nervosa |
0.228 |
0.0952 |
0.0166 |
Wald ratio |
1 |
cis |
NA |
| Forced vital capacity (FVC) |
0.017 |
0.00717 |
0.0175 |
Wald ratio |
1 |
cis |
NA |
| …and 104 more outcomes (see JSON) |
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|
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|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3484_60_2 |
Angiotensinogen |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
111 association rows across 65 traits (103 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating TGFBI levels |
2e-438 |
rs2493134 |
2 |
GCST90860488 |
no MR -> candidate analysis |
| AGT protein levels |
5e-157 |
rs56073403 |
8 |
GCST90468257 |
no MR -> candidate analysis |
| Pseudouridylate synthase 7 homolog levels |
2e-130 |
rs4762 |
1 |
GCST90424834 |
no MR -> candidate analysis |
| Shadow of prion protein levels |
2e-78 |
rs4762 |
2 |
GCST90422145 |
no MR -> candidate analysis |
| Angiotensinogen levels |
3e-75 |
rs11122580 |
6 |
GCST90246506 |
no MR -> candidate analysis |
| TGFBI protein levels |
6e-49 |
rs12409662 |
4 |
GCST90470845 |
no MR -> candidate analysis |
| Diastolic blood pressure |
7e-46 |
rs699 |
9 |
GCST90310295 |
MR: beta=0.0608, p=1.04e-11 (cis) |
| Systolic blood pressure |
8e-41 |
rs699 |
10 |
GCST90310294 |
MR: beta=0.0524, p=4.70e-09 (cis) |
| Serum levels of protein PRG2 |
3e-39 |
rs2478539 |
1 |
GCST90089768 |
no MR -> candidate analysis |
| Diastolic blood pressure (MTAG) |
7e-38 |
rs699 |
2 |
GCST90449057 |
no MR -> candidate analysis |
| Thiopurine S-methyltransferase levels |
2e-34 |
rs35837081 |
1 |
GCST90421376 |
no MR -> candidate analysis |
| Systolic blood pressure (MTAG) |
5e-33 |
rs699 |
2 |
GCST90449056 |
no MR -> candidate analysis |
| …and 53 more traits (see JSON) |
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|
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|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 2285 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| renal tubular dysgenesis |
0.779 |
— |
established (curated) |
no MR -> candidate analysis |
| renal tubular dysgenesis of genetic origin |
0.676 |
— |
established (curated) |
no MR -> candidate analysis |
| essential hypertension |
0.869 |
— |
common-variant locus |
no MR -> candidate analysis |
| hypertensive disorder |
0.757 |
— |
established (curated) |
no MR -> candidate analysis |
| cardiovascular disorder |
0.784 |
— |
common-variant locus |
no MR -> candidate analysis |
| essential hypertension, genetic |
0.637 |
— |
established (curated) |
no MR -> candidate analysis |
| atrial fibrillation |
0.691 |
— |
common-variant locus |
no MR -> candidate analysis |
| Increased blood pressure |
0.738 |
— |
common-variant locus |
no MR -> candidate analysis |
| coronary artery disorder |
0.59 |
— |
common-variant locus |
no MR -> candidate analysis |
| Anhydramnios |
0.569 |
— |
established (curated) |
no MR -> candidate analysis |
| Large fontanelles |
0.547 |
— |
established (curated) |
no MR -> candidate analysis |
| alcohol drinking |
0.542 |
— |
common-variant locus |
no MR -> candidate analysis |
| response to xenobiotic stimulus |
0.432 |
— |
common-variant locus |
no MR -> candidate analysis |
| ocular hypotension |
0.409 |
— |
common-variant locus |
no MR -> candidate analysis |
| hereditary disease |
0.312 |
— |
established (curated) |
no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Alanine–glyoxylate aminotransferase) |
| gnomAD constraint |
pLI=5.7e-09, LOEUF=1.28 — LoF-tolerant |
| GWAS Catalog |
81 unique SNPs / 161 rows |
| ClinVar |
326 records; 7 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
13 clinical annotations across 11 drugs |
phenome — Top 30 of 2285 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘AGT’ and resolved to ‘Alanine–glyoxylate aminotransferase’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 326 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 65 traits by best p-value, aggregated from 111 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P01019 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000135744/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL5169121/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/AGT — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/AGT — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=AGT%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=AGT — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/AGT — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T00:58:35 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none