Protein Dossier — AHSG (Alpha-2-HS-glycoprotein)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: diverticular disease or diverticulitis |
0.102 |
0.0367 |
0.00566 |
Wald ratio |
1 |
cis |
NA |
| Endometrioid ovarian cancer |
0.121 |
0.0524 |
0.0207 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter |
-0.135 |
0.0588 |
0.0213 |
Wald ratio |
1 |
cis |
NA |
| Paget’s disease |
0.259 |
0.117 |
0.0269 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: ankylosing spondylitis |
-0.228 |
0.103 |
0.0274 |
Wald ratio |
1 |
cis |
NA |
| Lumbar spine bone mineral density |
0.0345 |
0.0158 |
0.0294 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: bladder problem (not cancer) |
0.11 |
0.0506 |
0.0296 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Ankle |
0.0735 |
0.0341 |
0.0313 |
Wald ratio |
1 |
cis |
NA |
| Fractured or broken bones in last 5 years |
0.0277 |
0.013 |
0.0336 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypopituitarism |
0.35 |
0.17 |
0.04 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: pulmonary embolism (with or without) dvt |
0.0896 |
0.0436 |
0.0401 |
Wald ratio |
1 |
cis |
NA |
| Type 2 diabetes |
0.0627 |
0.0314 |
0.0457 |
Wald ratio |
1 |
cis |
NA |
| …and 94 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3581_53_3 |
a2-HS-Glycoprotein |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
117 association rows across 95 traits (114 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Alpha-2-HS-glycoprotein (analyte X10966.1) levels |
5e-1417 |
rs4917 |
1 |
GCST90421283 |
no MR -> candidate analysis |
| AHSG protein levels |
2e-211 |
rs140827890 |
7 |
GCST90468263 |
no MR -> candidate analysis |
| Alpha-2-HS-glycoprotein level in Chronic kidney disease with |
3e-197 |
rs4917 |
1 |
GCST90233040 |
no MR -> candidate analysis |
| Circulating ENTPD5 levels |
3e-144 |
rs35457250 |
1 |
GCST90860373 |
no MR -> candidate analysis |
| ENTPD5 protein levels |
6e-118 |
rs35457250 |
1 |
GCST90469121 |
no MR -> candidate analysis |
| Serum calciprotein particle maturation time (T50) |
2e-101 |
rs4917 |
1 |
GCST90102513 |
no MR -> candidate analysis |
| PINLYP protein levels |
3e-90 |
rs35457250 |
1 |
GCST90470238 |
no MR -> candidate analysis |
| PDZK1 protein levels |
3e-78 |
rs1900618 |
2 |
GCST90470203 |
no MR -> candidate analysis |
| Glycoprotein acetyls levels |
4e-77 |
rs4918 |
4 |
GCST90501111 |
no MR -> candidate analysis |
| Protein FAM210A protein levels (SomaScan ID:10966-1) |
3e-75 |
rs4917 |
1 |
GCST90442358 |
no MR -> candidate analysis |
| PXK protein levels |
2e-71 |
rs4918 |
1 |
GCST90453317 |
no MR -> candidate analysis |
| VWA1 protein levels |
2e-58 |
rs35457250 |
1 |
GCST90471061 |
no MR -> candidate analysis |
| …and 83 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 1892 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Alopecia-intellectual disability syndrome |
0.561 |
— |
established (curated) |
no MR -> candidate analysis |
| otosclerosis |
0.718 |
— |
common-variant locus |
no MR -> candidate analysis |
| alopecia - intellectual disability syndrome |
0.608 |
— |
established (curated) |
no MR -> candidate analysis |
Of the 3 rows above, 3 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Alpha-2-HS-glycoprotein) |
| gnomAD constraint |
pLI=8.5e-07, LOEUF=1.08 — LoF-tolerant |
| GWAS Catalog |
179 unique SNPs / 458 rows |
| ClinVar |
123 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 1892 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘AHSG’ and resolved to ‘Alpha-2-HS-glycoprotein’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 123 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 95 traits by best p-value, aggregated from 117 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P02765 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000145192/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4295694/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/AHSG — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/AHSG — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=AHSG%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/AHSG — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T00:59:00 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none