MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Body mass index (BMI) | 0.0304 | 0.013 | 0.0192 | Wald ratio | 1 | cis | NA |
| Eye problems or disorders: Injury or trauma resulting in loss of vision | 0.293 | 0.129 | 0.0231 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: gout | 0.203 | 0.0898 | 0.0236 | Wald ratio | 1 | cis | NA |
| Hirschsprung’s disease | -1.54 | 0.724 | 0.0329 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: D25 Leiomyoma of uterus | -0.329 | 0.165 | 0.046 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: G47 Sleep disorders | 0.265 | 0.133 | 0.0464 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: deep venous thrombosis (dvt) | 0.156 | 0.0794 | 0.0493 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K20 Oesophagitis | 0.202 | 0.109 | 0.0634 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter | -0.557 | 0.301 | 0.0637 | Wald ratio | 1 | cis | NA |
| Intracranial volume | -2.01e+04 | 1.13e+04 | 0.0752 | Wald ratio | 1 | cis | NA |
| Weight | -0.0196 | 0.0115 | 0.0873 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K44 Diaphragmatic hernia | -0.228 | 0.134 | 0.0881 | Wald ratio | 1 | cis | NA |
| …and 60 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
No GWAS Catalog associations mapped to this gene.
Top diseases by Open Targets association (of 144 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| nephrotic syndrome | 0.452 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.405 | — | common-variant locus | no MR -> candidate analysis |
| phobic disorder | 0.331 | — | common-variant locus | no MR -> candidate analysis |
| poisoning | 0.331 | — | common-variant locus | no MR -> candidate analysis |
| systemic lupus erythematosus | 0.132 | — | common-variant locus | no MR -> candidate analysis |
| male reproductive organ cancer | 0.121 | — | common-variant locus | no MR -> candidate analysis |
| transient ischemic attack | 0.1 | — | common-variant locus | no MR -> candidate analysis |
Of the 7 rows above, 7 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Alkaline phosphatase, germ cell type) |
| gnomAD constraint | not available |
| GWAS Catalog | no mapped SNPs |
| ClinVar | no records |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 144 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘ALPPL2’ and resolved to ‘Alkaline phosphatase, germ cell type’ — confirm this is the intended target.gnomad — No gnomAD constraint data.gwas — No GWAS Catalog SNPs mapped to this gene.clinvar — No ClinVar records.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — No GWAS Catalog associations mapped to this gene.uniprot: https://www.uniprot.org/uniprotkb/P10696 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000163286/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3402/ — ChEMBL_37 (released 2026-05-01)