MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Forced vital capacity (FVC) | -0.0717 | 0.0181 | 7.18e-05 | Wald ratio | 1 | trans | NA |
| Forced expiratory volume in 1-second (FEV1) | -0.0667 | 0.019 | 4.62e-04 | Wald ratio | 1 | trans | NA |
| Height | -0.0855 | 0.0265 | 0.00126 | Wald ratio | 1 | trans | NA |
| Total cholesterol | 0.136 | 0.0444 | 0.00223 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: G47 Sleep disorders | 0.531 | 0.175 | 0.00241 | Wald ratio | 1 | trans | NA |
| LDL cholesterol | 0.131 | 0.0453 | 0.00389 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level | 0.775 | 0.278 | 0.00535 | Wald ratio | 1 | trans | NA |
| Ovarian cancer | 0.317 | 0.119 | 0.00786 | Wald ratio | 1 | trans | NA |
| High grade serous ovarian cancer | 0.368 | 0.142 | 0.0095 | Wald ratio | 1 | trans | NA |
| Sleep duration | 0.0444 | 0.0172 | 0.00968 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: hayfever or allergic rhinitis | 0.193 | 0.0751 | 0.0102 | Wald ratio | 1 | trans | NA |
| Femoral neck bone mineral density | -0.178 | 0.0696 | 0.0106 | Wald ratio | 1 | trans | NA |
| …and 98 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
32 association rows across 25 traits (27 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating AMBP levels | 1e-257 | rs147941577 | 4 | GCST90859790 | no MR -> candidate analysis |
| AMBP protein levels | 1e-200 | rs147941577 | 3 | GCST90468288 | no MR -> candidate analysis |
| Hepatocyte nuclear factor 4-alpha levels | 5e-153 | rs141738059 | 1 | GCST90247907 | no MR -> candidate analysis |
| Sulfatase-modifying factor 1 levels | 3e-69 | rs141738059 | 1 | GCST90249730 | no MR -> candidate analysis |
| Tissue factor levels | 2e-31 | rs141738059 | 2 | GCST90249810 | no MR -> candidate analysis |
| Signaling lymphocytic activation molecule levels | 1e-29 | rs141738059 | 1 | GCST90249563 | no MR -> candidate analysis |
| Malignant T-cell-amplified sequence 1 levels | 4e-29 | rs141738059 | 1 | GCST90248530 | no MR -> candidate analysis |
| Calcipressin-1 levels | 2e-27 | rs141738059 | 1 | GCST90246924 | no MR -> candidate analysis |
| Alpha-1-microglobulin levels | 5e-25 | rs10817564 | 1 | GCST90246393 | no MR -> candidate analysis |
| Protein AMBP levels | 3e-24 | rs147941577 | 1 | GCST90179222 | no MR -> candidate analysis |
| Hepatocyte nuclear factor 4-alpha levels (HNF4A.10041.3.3) | 1e-20 | rs141738059 | 1 | GCST90241401 | no MR -> candidate analysis |
| Protein kinase C gamma type levels | 4e-19 | rs141738059 | 1 | GCST90249013 | no MR -> candidate analysis |
| …and 13 more traits (see JSON) |
Top diseases by Open Targets association (of 315 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| osteoarthritis | 0.097 | — | common-variant locus | MR: beta=-0.62, p=0.0157 (trans) |
| osteoarthritis, knee | 0.092 | — | common-variant locus | MR: beta=-0.349, p=0.0864 (trans) |
| arthropathy | 0.087 | — | common-variant locus | no MR -> candidate analysis |
| Knee pain | 0.08 | — | common-variant locus | no MR -> candidate analysis |
| osteoarthritis, hip | 0.079 | — | common-variant locus | MR: beta=-0.62, p=0.0157 (trans) |
| placental retention | 0.073 | — | common-variant locus | no MR -> candidate analysis |
| ovarian neoplasm | 0.065 | — | common-variant locus | no MR -> candidate analysis |
| acute pancreatitis | 0.063 | — | common-variant locus | no MR -> candidate analysis |
| response to clozapine | 0.06 | — | common-variant locus | no MR -> candidate analysis |
| diabetes mellitus | 0.051 | — | common-variant locus | no MR -> candidate analysis |
| type 2 diabetes mellitus | 0.051 | — | common-variant locus | no MR -> candidate analysis |
| medical procedure | 0.056 | — | common-variant locus | no MR -> candidate analysis |
| androgenetic alopecia | 0.057 | — | common-variant locus | no MR -> candidate analysis |
| breast carcinoma | 0.043 | — | common-variant locus | no MR -> candidate analysis |
| total knee arthroplasty | 0.053 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 12 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=9.6e-11, LOEUF=1.05 — LoF-tolerant |
| GWAS Catalog | 78 unique SNPs / 155 rows |
| ClinVar | 120 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 315 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘AMBP’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 120 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 25 traits by best p-value, aggregated from 32 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P02760 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000106927/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/AMBP — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/AMBP — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=AMBP%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/AMBP — GWAS Catalog search API (live; release not exposed)