Protein Dossier — ANG (Angiogenin)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Diagnoses - main ICD10: B37 Candidiasis |
0.485 |
0.14 |
5.53e-04 |
Wald ratio |
1 |
cis |
NA |
| Microalbuminuria |
0.124 |
0.0397 |
0.00178 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: polio or poliomyelitis |
0.358 |
0.127 |
0.00484 |
Wald ratio |
1 |
cis |
NA |
| Serum cystatin C (eGFRcys) |
-0.00967 |
0.00372 |
0.00932 |
Wald ratio |
1 |
cis |
NA |
| Potassium in urine |
-0.0123 |
0.00474 |
0.0095 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: vitiligo |
0.471 |
0.184 |
0.0105 |
Wald ratio |
1 |
cis |
NA |
| Eye problems or disorders: Glaucoma |
0.088 |
0.0357 |
0.0136 |
Wald ratio |
1 |
cis |
NA |
| Hip osteoarthritis |
0.118 |
0.0545 |
0.0302 |
Wald ratio |
1 |
cis |
NA |
| Systemic lupus erythematosus |
-0.183 |
0.0884 |
0.0381 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R07 Pain in throat and chest |
-0.0438 |
0.0218 |
0.0443 |
Wald ratio |
1 |
cis |
NA |
| Neo-extraversion |
-0.297 |
0.155 |
0.0555 |
Wald ratio |
1 |
cis |
NA |
| Vascular or heart problems diagnosed by doctor: Angina |
-0.0528 |
0.0276 |
0.0562 |
Wald ratio |
1 |
cis |
NA |
| …and 100 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4874_3_1 |
Angiogenin |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
38 association rows across 15 traits (34 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating ANG levels |
1e-1158 |
rs10220701 |
5 |
GCST90860430 |
no MR -> candidate analysis |
| ANG/F9 protein level ratio |
6e-1118 |
rs17114671 |
1 |
GCST90313259 |
no MR -> candidate analysis |
| Angiogenin levels |
3e-452 |
rs11851044 |
11 |
GCST90246501 |
no MR -> candidate analysis |
| Serum levels of protein ANG |
2e-86 |
rs36071889 |
2 |
GCST90088789 |
no MR -> candidate analysis |
| ANG protein levels |
1e-69 |
rs552960263 |
4 |
GCST90468307 |
no MR -> candidate analysis |
| RNASE4 protein levels |
1e-63 |
rs780392419 |
3 |
GCST90470478 |
no MR -> candidate analysis |
| Ribonuclease 4 levels |
8e-45 |
rs4470055 |
3 |
GCST90426424 |
no MR -> candidate analysis |
| Ribonuclease 4 levels (RNASE4.5644.60.3) |
1e-36 |
rs184297073 |
2 |
GCST90242666 |
no MR -> candidate analysis |
| Blood protein levels |
1e-18 |
rs1888560 |
1 |
GCST006585 |
no MR -> candidate analysis |
| Protein quantitative trait loci |
1e-17 |
rs34121942 |
1 |
GCST010900 |
no MR -> candidate analysis |
| Ribonuclease 4 level in Chronic kidney disease with hyperten |
4e-15 |
rs944438 |
1 |
GCST90238008 |
no MR -> candidate analysis |
| Tyrosine-protein phosphatase non-receptor type substrate 1 p |
9e-9 |
rs17516133 |
1 |
GCST90439340 |
no MR -> candidate analysis |
| …and 3 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 643 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| amyotrophic lateral sclerosis |
0.917 |
— |
established (curated) |
no MR -> candidate analysis |
| frontotemporal dementia |
0.426 |
— |
established (curated) |
no MR -> candidate analysis |
| hereditary disease |
0.306 |
— |
established (curated) |
no MR -> candidate analysis |
| frontotemporal dementia with motor neuron disease |
0.195 |
— |
established (curated) |
no MR -> candidate analysis |
| schizophrenia |
0.116 |
— |
common-variant locus |
MR: beta=0.0187, p=0.366 (cis) |
Of the 5 rows above, 4 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
8 known modulators (Angiopoietin-2) |
| gnomAD constraint |
pLI=NA, LOEUF=NA — Constraint metrics missing; LoF tolerance cannot be judged. |
| GWAS Catalog |
108 unique SNPs / 225 rows |
| ClinVar |
158 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 643 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘ANG’ and resolved to ‘Angiopoietin-2’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 158 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 15 of 15 traits by best p-value, aggregated from 38 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P03950 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000214274/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3580489/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/ANG — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/ANG — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=ANG%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/ANG — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:03:16 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none