Protein Dossier — ANXA2 (Annexin A2)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Age at menarche |
-0.0351 |
0.00894 |
8.90e-05 |
Wald ratio |
1 |
cis |
NA |
| Weight |
-0.0105 |
0.00317 |
8.68e-04 |
Wald ratio |
1 |
cis |
NA |
| Amygdala volume |
-9.2 |
3.48 |
0.00813 |
Wald ratio |
1 |
cis |
NA |
| Birth weight |
-0.0133 |
0.00557 |
0.0169 |
Wald ratio |
1 |
cis |
NA |
| HOMA-IR |
0.0144 |
0.00608 |
0.0176 |
Wald ratio |
1 |
cis |
NA |
| Fasting proinsulin |
0.0237 |
0.0102 |
0.0202 |
Wald ratio |
1 |
cis |
NA |
| Putamen volume |
-20.5 |
8.89 |
0.021 |
Wald ratio |
1 |
cis |
NA |
| Platelet count |
-1.39 |
0.603 |
0.0212 |
Wald ratio |
1 |
cis |
NA |
| Body mass index (BMI) |
-0.00792 |
0.00359 |
0.0271 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: C50 Malignant neoplasm of breast |
0.0582 |
0.0265 |
0.0279 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: anxiety or panic attacks |
0.0626 |
0.029 |
0.0312 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: high cholesterol |
-0.0208 |
0.0099 |
0.0359 |
Wald ratio |
1 |
cis |
NA |
| …and 107 more outcomes (see JSON) |
|
|
|
|
|
|
|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4961_17_1 |
annexin II |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
50 association rows across 31 traits (36 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Annexin A2 levels |
6e-987 |
rs8033800 |
8 |
GCST90246522 |
no MR -> candidate analysis |
| ANXA2 protein levels |
7e-99 |
rs6494191 |
11 |
GCST90468317 |
no MR -> candidate analysis |
| KLRB1 protein levels |
3e-23 |
rs11071528 |
1 |
GCST90469709 |
no MR -> candidate analysis |
| Height |
3e-17 |
rs8040209 |
2 |
GCST90245848 |
MR: beta=-0.00567, p=0.211 (cis) |
| Circulating FLT4 levels |
2e-15 |
rs17845226 |
1 |
GCST90860081 |
no MR -> candidate analysis |
| FLT4 protein levels |
8e-15 |
rs17845226 |
1 |
GCST90469252 |
no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) |
9e-14 |
rs11071528 |
1 |
GCST90838669 |
no MR -> candidate analysis |
| Serum levels of protein ANXA2 |
6e-13 |
rs61381915 |
1 |
GCST90088827 |
no MR -> candidate analysis |
| Blood protein levels |
2e-10 |
rs61381915 |
1 |
GCST006585 |
no MR -> candidate analysis |
| Total PHF-tau (SNP x SNP interaction) |
2e-10 |
rs10196561 x rs2414660 |
1 |
GCST010340 |
no MR -> candidate analysis |
| Bioavailable testosterone levels |
2e-9 |
rs12437778 |
1 |
GCST90027085 |
no MR -> candidate analysis |
| Bcl-2-like protein 11 protein levels (SomaScan ID:13700-10) |
3e-9 |
rs12440452 |
1 |
GCST90438342 |
no MR -> candidate analysis |
| …and 19 more traits (see JSON) |
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|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 697 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| benign urinary system neoplasm |
0.486 |
— |
common-variant locus |
no MR -> candidate analysis |
| multiple sclerosis |
0.035 |
— |
common-variant locus |
no MR -> candidate analysis |
| ovarian neoplasm |
0.447 |
— |
common-variant locus |
no MR -> candidate analysis |
| Hallux valgus |
0.388 |
— |
common-variant locus |
no MR -> candidate analysis |
| myasthenia gravis |
0.384 |
— |
common-variant locus |
no MR -> candidate analysis |
| biliary tract disorder |
0.377 |
— |
common-variant locus |
no MR -> candidate analysis |
| diabetes mellitus |
0.352 |
— |
common-variant locus |
no MR -> candidate analysis |
| mastodynia |
0.355 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 8 rows above, 8 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Annexin A2) |
| gnomAD constraint |
pLI=1.1e-05, LOEUF=0.812 — LoF-tolerant |
| GWAS Catalog |
66 unique SNPs / 113 rows |
| ClinVar |
69 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 697 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘ANXA2’ and resolved to ‘Annexin A2’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 69 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 31 traits by best p-value, aggregated from 50 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P07355 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000182718/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL1764938/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/ANXA2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/ANXA2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=ANXA2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/ANXA2 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:04:43 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none