MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Height | -0.0417 | 0.012 | 4.92e-04 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hyperthyroidism or thyrotoxicosis | -0.555 | 0.202 | 0.00611 | Wald ratio | 1 | cis | NA |
| Forced expiratory volume in 1-second (FEV1) | -0.0219 | 0.00822 | 0.00779 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: diverticular disease or diverticulitis | 0.192 | 0.0747 | 0.0101 | Wald ratio | 1 | cis | NA |
| Fractured bone site(s): Wrist | 0.146 | 0.0589 | 0.0132 | Wald ratio | 1 | cis | NA |
| Bipolar disorder | 0.233 | 0.0973 | 0.0167 | Wald ratio | 1 | cis | NA |
| Cigarettes smoked per day | 0.787 | 0.332 | 0.0178 | Wald ratio | 1 | cis | NA |
| Myocardial infarction | 0.0954 | 0.0406 | 0.0187 | Wald ratio | 1 | cis | NA |
| Forced vital capacity (FVC) | -0.0177 | 0.00779 | 0.0234 | Wald ratio | 1 | cis | NA |
| Body mass index (BMI) | 0.0213 | 0.00951 | 0.0253 | Wald ratio | 1 | cis | NA |
| Diastolic blood pressure automated reading | -0.02 | 0.00974 | 0.0405 | Wald ratio | 1 | cis | NA |
| Eye problems or disorders: Diabetes related eye disease | 0.205 | 0.101 | 0.042 | Wald ratio | 1 | cis | NA |
| …and 83 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
886 association rows across 609 traits (871 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Metastasis-suppressor KiSS-1 levels | 3e-1155 | rs1801690 | 1 | GCST90248203 | no MR -> candidate analysis |
| ATP-dependent RNA helicase DHX8 levels | 1e-819 | rs7212477 | 2 | GCST90247282 | no MR -> candidate analysis |
| Blood protein levels | 7e-431 | rs1801690 | 9 | GCST006585 | no MR -> candidate analysis |
| Beta-2-glycoprotein 1 levels | 1e-423 | rs1801689 | 2 | GCST90246626 | no MR -> candidate analysis |
| Circulating LTBP3 levels | 3e-382 | rs8178824 | 1 | GCST90860758 | no MR -> candidate analysis |
| V-set and immunoglobulin domain-containing protein 2 levels | 2e-270 | rs1801690 | 1 | GCST90250193 | no MR -> candidate analysis |
| IL18R1 protein levels | 1e-251 | rs1801689 | 1 | GCST90469565 | no MR -> candidate analysis |
| TXNDC15 protein levels | 6e-239 | rs1801689 | 1 | GCST90470990 | no MR -> candidate analysis |
| PRSS53 protein levels | 1e-233 | rs1801689 | 1 | GCST90470344 | no MR -> candidate analysis |
| ATP-dependent RNA helicase DHX8 levels (DHX8.11601.26.3) | 2e-232 | rs8178854 | 2 | GCST90240355 | no MR -> candidate analysis |
| APOH protein levels | 6e-229 | rs118088174 | 7 | GCST90468340 | no MR -> candidate analysis |
| Circulating IL18R1 levels | 6e-222 | rs8178824 | 1 | GCST90859873 | no MR -> candidate analysis |
| …and 597 more traits (see JSON) |
Top diseases by Open Targets association (of 523 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| atrial fibrillation | 0.903 | — | common-variant locus | no MR -> candidate analysis |
| Hypercholesterolemia | 0.813 | — | common-variant locus | MR: beta=0.0127, p=0.369 (cis) |
| metabolic syndrome | 0.787 | — | common-variant locus | no MR -> candidate analysis |
| familial lipoprotein lipase deficiency | 0.749 | — | common-variant locus | no MR -> candidate analysis |
| atrial flutter | 0.644 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.603 | — | common-variant locus | no MR -> candidate analysis |
| response to statin | 0.589 | — | common-variant locus | no MR -> candidate analysis |
| ovarian endometriosis | 0.523 | — | common-variant locus | no MR -> candidate analysis |
| chronic obstructive pulmonary disease | 0.507 | — | common-variant locus | no MR -> candidate analysis |
| cardiac arrhythmia | 0.507 | — | common-variant locus | no MR -> candidate analysis |
| lung abscess | 0.461 | — | common-variant locus | no MR -> candidate analysis |
| bronchopneumonia | 0.461 | — | common-variant locus | no MR -> candidate analysis |
| nonischemic cardiomyopathy | 0.303 | — | common-variant locus | no MR -> candidate analysis |
| heart failure | 0.292 | — | common-variant locus | no MR -> candidate analysis |
| stroke disorder | 0.045 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=1.4e-19, LOEUF=1.54 — LoF-tolerant |
| GWAS Catalog | 108 unique SNPs / 221 rows |
| ClinVar | 58 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 523 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘APOH’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 58 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 609 traits by best p-value, aggregated from 886 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P02749 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000091583/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/APOH — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/APOH — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=APOH%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/APOH — GWAS Catalog search API (live; release not exposed)