MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Systolic blood pressure automated reading | 0.048 | 0.0151 | 0.00149 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: C50 Malignant neoplasm of breast | -0.57 | 0.215 | 0.00819 | Wald ratio | 1 | cis | NA |
| Diastolic blood pressure automated reading | 0.0388 | 0.0151 | 0.0102 | Wald ratio | 1 | cis | NA |
| Pulse rate | 0.0616 | 0.0262 | 0.0187 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N92 Excessive frequent and irregular menstruation | -0.331 | 0.147 | 0.024 | Wald ratio | 1 | cis | NA |
| Alcohol intake frequency | -0.0439 | 0.0218 | 0.0438 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K40 Inguinal hernia | -0.212 | 0.113 | 0.0614 | Wald ratio | 1 | cis | NA |
| Cancer code self-reported: basal cell carcinoma | 0.211 | 0.127 | 0.096 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: gastro-oesophageal reflux (gord) or gastric reflux | 0.107 | 0.0641 | 0.096 | Wald ratio | 1 | cis | NA |
| Fractured bone site(s): Arm | 0.202 | 0.123 | 0.102 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: emphysema or chronic bronchitis | -0.275 | 0.174 | 0.114 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: H25 Senile cataract | -0.429 | 0.284 | 0.131 | Wald ratio | 1 | cis | NA |
| …and 64 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
39 association rows across 34 traits (37 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Monounsaturated fatty acids to total fatty acids percentage | 1e-27 | rs4603265 | 4 | GCST90501219 | no MR -> candidate analysis |
| Hypertrophic cardiomyopathy | 2e-24 | rs187474069 | 1 | GCST90018861 | MR: beta=0.8, p=0.299 (cis) |
| Serum levels of protein ARHGAP1 | 1e-20 | rs144801476 | 1 | GCST90086893 | no MR -> candidate analysis |
| Heel bone mineral density | 4e-20 | rs764166931 | 1 | GCST006433 | no MR -> candidate analysis |
| Femoral neck bone mineral density | 5e-18 | rs7932354 | 1 | GCST007691 | no MR -> candidate analysis |
| Metabolic syndrome | 5e-18 | rs4603265 | 1 | GCST90859207 | no MR -> candidate analysis |
| Triglyceride percentage of total lipids in intermediate-dens | 2e-17 | rs4603265 | 1 | GCST90454489 | no MR -> candidate analysis |
| Triglyceride to phosphoglyceride ratio | 4e-16 | rs4603265 | 1 | GCST90454483 | no MR -> candidate analysis |
| GLIPR1 protein levels | 2e-15 | rs184204306 | 1 | GCST90469357 | no MR -> candidate analysis |
| Triacylglycerol 36:0(FA12:0) (Model 1) | 7e-15 | rs142892685 | 1 | GCST90830355 | no MR -> candidate analysis |
| Metabolic syndrome cluster 1 (non-descriptive endotype) | 3e-14 | rs4603265 | 1 | GCST90859208 | no MR -> candidate analysis |
| Pulmonary embolism | 5e-14 | rs141481090 | 1 | GCST90468148 | no MR -> candidate analysis |
| …and 22 more traits (see JSON) |
Top diseases by Open Targets association (of 488 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| heart disorder | 0.527 | — | common-variant locus | no MR -> candidate analysis |
| pulmonary embolism | 0.482 | — | common-variant locus | no MR -> candidate analysis |
| hypertrophic cardiomyopathy | 0.48 | — | common-variant locus | MR: beta=0.8, p=0.299 (cis) |
| cardiomyopathy | 0.431 | — | common-variant locus | MR: beta=0.8, p=0.299 (cis) |
| Pulmonary Infarction | 0.418 | — | common-variant locus | no MR -> candidate analysis |
| deep vein thrombosis | 0.411 | — | common-variant locus | no MR -> candidate analysis |
| schizophrenia | 0.246 | — | common-variant locus | no MR -> candidate analysis |
| Familial exudative vitreoretinopathy | 0.228 | — | established (curated) | no MR -> candidate analysis |
| heart failure | 0.21 | — | common-variant locus | no MR -> candidate analysis |
| aneurysm | 0.131 | — | common-variant locus | no MR -> candidate analysis |
| hypertensive disorder | 0.101 | — | common-variant locus | no MR -> candidate analysis |
| venous thromboembolism | 0.099 | — | common-variant locus | no MR -> candidate analysis |
| essential hypertension | 0.085 | — | common-variant locus | no MR -> candidate analysis |
Of the 13 rows above, 11 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.055, LOEUF=0.625 — LoF-tolerant |
| GWAS Catalog | 89 unique SNPs / 178 rows |
| ClinVar | 102 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 488 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘ARHGAP1’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 102 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 34 traits by best p-value, aggregated from 39 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q07960 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000175220/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/ARHGAP1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/ARHGAP1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=ARHGAP1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/ARHGAP1 — GWAS Catalog search API (live; release not exposed)