MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Amyotrophic lateral sclerosis | 0.171 | 0.0761 | 0.0248 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: migraine | -0.154 | 0.069 | 0.0259 | Wald ratio | 1 | trans | NA |
| Small vessel disease | 0.339 | 0.155 | 0.0288 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: R35 Polyuria | 0.275 | 0.126 | 0.0294 | Wald ratio | 1 | trans | NA |
| Sleep duration | 0.0163 | 0.00795 | 0.0398 | Wald ratio | 1 | trans | NA |
| Fracture resulting from simple fall | 0.0511 | 0.0255 | 0.045 | Wald ratio | 1 | trans | NA |
| PGC cross-disorder traits | 0.101 | 0.0517 | 0.0504 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: I84 Haemorrhoids | 0.114 | 0.0586 | 0.0518 | Wald ratio | 1 | trans | NA |
| Sodium in urine | 0.0195 | 0.01 | 0.0523 | Wald ratio | 1 | trans | NA |
| Alzheimer’s disease | 0.135 | 0.0693 | 0.0524 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: K40 Inguinal hernia | 0.108 | 0.0561 | 0.0535 | Wald ratio | 1 | trans | NA |
| Coronary heart disease | 0.0757 | 0.0397 | 0.0566 | Wald ratio | 1 | trans | NA |
| …and 81 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
40 association rows across 30 traits (22 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Rho guanine nucleotide exchange factor 10 levels | 4e-37 | rs7832438 | 1 | GCST90427632 | no MR -> candidate analysis |
| ARHGEF10 protein levels | 2e-36 | rs17829719 | 9 | GCST90468357 | no MR -> candidate analysis |
| Localized adiposity (PheCode 278.3) | 1e-11 | rs535493541 | 1 | GCST90479953 | no MR -> candidate analysis |
| X-11315 levels | 9e-11 | rs143689932 | 1 | GCST90503991 | no MR -> candidate analysis |
| Gut microbial network clusters (Turquoise (at 3 months) x Ex | 5e-9 | rs117374333 | 2 | GCST90569282 | no MR -> candidate analysis |
| Gut microbial network clusters (Turquoise (at 3 months) x An | 5e-9 | rs117374333 | 2 | GCST90569283 | no MR -> candidate analysis |
| Delta-6 desaturase activity response to n3-polyunsaturated f | 9e-9 | rs2280885 | 1 | GCST005669 | no MR -> candidate analysis |
| Dementia | 9e-9 | rs7006786 | 1 | GCST90449022 | no MR -> candidate analysis |
| Refractive error | 1e-8 | rs2280823 | 1 | GCST90841196 | no MR -> candidate analysis |
| Optic disc size | 3e-8 | rs80218807 | 1 | GCST009462 | no MR -> candidate analysis |
| Total bilirubin levels | 3e-8 | rs539338508 | 1 | GCST90662900 | no MR -> candidate analysis |
| Gut microbiome abundance (class Clostridium sensu stricto sp | 4e-8 | rs10441637 | 1 | GCST90569031 | no MR -> candidate analysis |
| …and 18 more traits (see JSON) |
Top diseases by Open Targets association (of 272 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| autosomal dominant slowed nerve conduction velocity | 0.585 | — | established (curated) | no MR -> candidate analysis |
| Charcot-Marie-Tooth disease | 0.503 | — | established (curated) | no MR -> candidate analysis |
| alcohol drinking | 0.457 | — | common-variant locus | no MR -> candidate analysis |
| stroke disorder | 0.445 | — | common-variant locus | no MR -> candidate analysis |
| response to polyunsaturated fatty acid supplementation | 0.427 | — | common-variant locus | no MR -> candidate analysis |
| atrial septal defect | 0.395 | — | common-variant locus | no MR -> candidate analysis |
| dementia | 0.395 | — | common-variant locus | no MR -> candidate analysis |
| myeloid leukemia | 0.357 | — | common-variant locus | no MR -> candidate analysis |
Of the 8 rows above, 8 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=1.9e-45, LOEUF=1.09 — LoF-tolerant |
| GWAS Catalog | 66 unique SNPs / 132 rows |
| ClinVar | 1269 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 272 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘ARHGEF10’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 1269 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 30 traits by best p-value, aggregated from 40 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/O15013 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000104728/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/ARHGEF10 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/ARHGEF10 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=ARHGEF10%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/ARHGEF10 — GWAS Catalog search API (live; release not exposed)