MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Eczema | 0.252 | 0.0924 | 0.00641 | Wald ratio | 1 | trans | NA |
| Clear cell ovarian cancer | 0.409 | 0.17 | 0.016 | Wald ratio | 1 | trans | NA |
| Neuroticism | 0.0317 | 0.0132 | 0.0164 | Wald ratio | 1 | trans | NA |
| Invasive mucinous ovarian cancer | 0.405 | 0.17 | 0.0173 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: G56 Mononeuropathies of upper limb | 0.136 | 0.061 | 0.0254 | Wald ratio | 1 | trans | NA |
| Depressive symptoms | 0.0343 | 0.0158 | 0.0303 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: G47 Sleep disorders | 0.193 | 0.0996 | 0.0528 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: sleep apnoea | 0.249 | 0.131 | 0.0582 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: K20 Oesophagitis | 0.149 | 0.0803 | 0.0638 | Wald ratio | 1 | trans | NA |
| Endometrioid ovarian cancer | 0.223 | 0.127 | 0.0786 | Wald ratio | 1 | trans | NA |
| Myocardial infarction | 0.102 | 0.0589 | 0.0847 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: K35 Acute appendicitis | 0.189 | 0.11 | 0.0869 | Wald ratio | 1 | trans | NA |
| …and 61 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
91 association rows across 37 traits (79 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating FCRLB levels | 4e-272 | rs181939013 | 2 | GCST90860085 | no MR -> candidate analysis |
| FCGR3B protein levels | 5e-215 | rs78349639 | 10 | GCST90469202 | no MR -> candidate analysis |
| Circulating FCGR3B levels | 7e-201 | rs188703531 | 1 | GCST90860423 | no MR -> candidate analysis |
| FCGR2A protein levels | 1e-186 | rs9787369 | 4 | GCST90469200 | no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) | 2e-120 | rs10918341 | 2 | GCST90838667 | no MR -> candidate analysis |
| FCRLB protein levels | 6e-87 | rs11585262 | 15 | GCST90469210 | no MR -> candidate analysis |
| Non-albumin protein levels | 1e-85 | rs9787369 | 8 | GCST90019515 | no MR -> candidate analysis |
| White blood cell count (neutrophil) | 5e-83 | rs10918341 | 2 | GCST90026508 | no MR -> candidate analysis |
| White blood cell count | 2e-61 | rs2340727 | 4 | GCST008049 | no MR -> candidate analysis |
| Total protein levels (UKB data field 30860) | 2e-60 | rs71634909 | 5 | GCST90468105 | no MR -> candidate analysis |
| Serum total protein levels | 6e-54 | rs9787369 | 6 | GCST90019522 | no MR -> candidate analysis |
| Hematology traits | 2e-23 | rs2340727 | 1 | GCST001779 | no MR -> candidate analysis |
| …and 25 more traits (see JSON) |
Top diseases by Open Targets association (of 978 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| achromatopsia | 0.845 | — | established (curated) | no MR -> candidate analysis |
| Retinal dystrophy | 0.774 | — | established (curated) | no MR -> candidate analysis |
| Sensorineural hearing impairment | 0.684 | — | established (curated) | no MR -> candidate analysis |
| Cone rod dystrophy | 0.608 | — | established (curated) | no MR -> candidate analysis |
| cone-rod dystrophy | 0.608 | — | established (curated) | no MR -> candidate analysis |
| Rod-cone dystrophy | 0.608 | — | established (curated) | no MR -> candidate analysis |
| alcohol drinking | 0.438 | — | common-variant locus | no MR -> candidate analysis |
| Macular dystrophy | 0.426 | — | established (curated) | no MR -> candidate analysis |
| adolescent idiopathic scoliosis | 0.359 | — | common-variant locus | no MR -> candidate analysis |
| neutropenia | 0.329 | — | common-variant locus | no MR -> candidate analysis |
| Decreased total leukocyte count | 0.324 | — | common-variant locus | no MR -> candidate analysis |
| hereditary disease | 0.318 | — | established (curated) | no MR -> candidate analysis |
| cystic kidney disease | 0.171 | — | common-variant locus | no MR -> candidate analysis |
Of the 13 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Cyclic AMP-dependent transcription factor ATF-6 alpha) |
| gnomAD constraint | pLI=4e-11, LOEUF=0.797 — LoF-tolerant |
| GWAS Catalog | 162 unique SNPs / 417 rows |
| ClinVar | 542 records; 4 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 978 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘ATF6’ and resolved to ‘Cyclic AMP-dependent transcription factor ATF-6 alpha’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 542 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 37 traits by best p-value, aggregated from 91 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P18850 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000118217/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4105716/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/ATF6 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/ATF6 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=ATF6%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/ATF6 — GWAS Catalog search API (live; release not exposed)