MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Heel bone mineral density (BMD) T-score automated | -0.0582 | 0.0133 | 1.24e-05 | Wald ratio | 1 | cis | NA |
| Pallidum volume | 28.6 | 8.4 | 6.58e-04 | Wald ratio | 1 | cis | NA |
| Sodium in urine | 0.0334 | 0.0101 | 9.85e-04 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypertrophic cardiomyopathy (hcm or hocm) | 0.951 | 0.312 | 0.00226 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: retinal detachment | 0.378 | 0.125 | 0.00257 | Wald ratio | 1 | cis | NA |
| Diastolic blood pressure automated reading | 0.0312 | 0.0105 | 0.00313 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R07 Pain in throat and chest | 0.119 | 0.0408 | 0.00355 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: depression | 0.109 | 0.0381 | 0.00428 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I80 Phlebitis and thrombophlebitis | 0.302 | 0.113 | 0.00747 | Wald ratio | 1 | cis | NA |
| Neo-extraversion | 0.859 | 0.335 | 0.0104 | Wald ratio | 1 | cis | NA |
| ER-positive Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | 0.0838 | 0.0327 | 0.0105 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: Z09 Follow-up examination after treatment for conditions other than malignant neoplasms | 0.177 | 0.0706 | 0.0124 | Wald ratio | 1 | cis | NA |
| …and 106 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
No GWAS Catalog associations mapped to this gene.
Top diseases by Open Targets association (of 2491 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Peters plus syndrome | 0.848 | — | established (curated) | no MR -> candidate analysis |
| hereditary disease | 0.801 | — | established (curated) | no MR -> candidate analysis |
| age-related macular degeneration | 0.738 | — | common-variant locus | no MR -> candidate analysis |
| major depressive disorder | 0.732 | — | common-variant locus | no MR -> candidate analysis |
| COVID-19 | 0.687 | — | common-variant locus | no MR -> candidate analysis |
| mathematical ability | 0.623 | — | common-variant locus | no MR -> candidate analysis |
| insomnia | 0.561 | — | common-variant locus | no MR -> candidate analysis |
| health study participation | 0.516 | — | common-variant locus | no MR -> candidate analysis |
| wet macular degeneration | 0.501 | — | common-variant locus | no MR -> candidate analysis |
| risk-taking behaviour | 0.501 | — | common-variant locus | no MR -> candidate analysis |
| atrophic macular degeneration | 0.501 | — | common-variant locus | no MR -> candidate analysis |
| arthropathy | 0.486 | — | common-variant locus | no MR -> candidate analysis |
| Vertigo | 0.486 | — | common-variant locus | no MR -> candidate analysis |
| type 2 diabetes mellitus | 0.48 | — | common-variant locus | no MR -> candidate analysis |
| mental disorder | 0.475 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | not available |
| GWAS Catalog | 1 unique SNPs / 1 rows |
| ClinVar | no records |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 2491 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘B3GALTL’.gnomad — No gnomAD constraint data.clinvar — No ClinVar records.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — No GWAS Catalog associations mapped to this gene.uniprot: https://www.uniprot.org/uniprotkb/Q6Y288 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000187676/associations — Open Targets data release 26.06gwas: https://www.ebi.ac.uk/gwas/genes/B3GALTL — GWAS Catalog REST (live; release not exposed by this endpoint)