MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Height | -0.0376 | 0.00403 | 1.03e-20 | Wald ratio | 1 | cis | NA |
| Weight | -0.0128 | 0.00292 | 1.15e-05 | Wald ratio | 1 | cis | NA |
| Forced vital capacity (FVC) | -0.00985 | 0.00271 | 2.83e-04 | Wald ratio | 1 | cis | NA |
| Coronary heart disease | -0.0396 | 0.0126 | 0.00171 | Wald ratio | 1 | cis | NA |
| Diastolic blood pressure automated reading | 0.0104 | 0.00339 | 0.00211 | Wald ratio | 1 | cis | NA |
| Potassium in urine | -0.0103 | 0.00336 | 0.00227 | Wald ratio | 1 | cis | NA |
| Creatinine (enzymatic) in urine | -0.00959 | 0.00317 | 0.00248 | Wald ratio | 1 | cis | NA |
| Thyroid cancer | 0.34 | 0.115 | 0.00299 | Wald ratio | 1 | cis | NA |
| Sleep duration | -0.00749 | 0.00258 | 0.00377 | Wald ratio | 1 | cis | NA |
| Forced expiratory volume in 1-second (FEV1) | -0.00807 | 0.00286 | 0.00479 | Wald ratio | 1 | cis | NA |
| Thalamus volume | -22.8 | 8.47 | 0.00723 | Wald ratio | 1 | cis | NA |
| Ferritin | -0.0333 | 0.0128 | 0.00904 | Wald ratio | 1 | cis | NA |
| …and 112 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
33 association rows across 22 traits (32 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase | 9e-726 | rs284662 | 2 | GCST90246634 | no MR -> candidate analysis |
| N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransfera | 1e-328 | rs284662 | 1 | GCST90248603 | no MR -> candidate analysis |
| Blood protein levels | 1e-238 | rs284663 | 1 | GCST006585 | no MR -> candidate analysis |
| Serum levels of protein B3GNT2 | 6e-73 | rs284662 | 1 | GCST90089962 | no MR -> candidate analysis |
| B3GNT8 protein levels | 1e-72 | rs284662 | 1 | GCST90453319 | no MR -> candidate analysis |
| Height | 2e-72 | rs284661 | 8 | GCST90662911 | MR: beta=-0.0376, p=1.03e-20 (cis) |
| Body size or adipose distribution (multivariate analysis) | 1e-50 | rs284660 | 1 | GCST90624105 | no MR -> candidate analysis |
| CD27/CD79B protein level ratio | 1e-34 | rs284663 | 1 | GCST90313770 | no MR -> candidate analysis |
| Circulating ADAM23 levels | 5e-31 | rs2569754 | 1 | GCST90859683 | no MR -> candidate analysis |
| ADAM23 protein levels | 5e-30 | rs284662 | 1 | GCST90468219 | no MR -> candidate analysis |
| Phosphopantothenoylcysteine decarboxylase protein levels (So | 7e-26 | rs284662 | 1 | GCST90439264 | no MR -> candidate analysis |
| Circulating ISLR2 levels | 4e-24 | rs2569754 | 1 | GCST90860750 | no MR -> candidate analysis |
| …and 10 more traits (see JSON) |
Top diseases by Open Targets association (of 64 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| androgenetic alopecia | 0.26 | — | common-variant locus | no MR -> candidate analysis |
| atrial fibrillation | 0.179 | — | common-variant locus | no MR -> candidate analysis |
| heart failure | 0.17 | — | common-variant locus | no MR -> candidate analysis |
| hair color | 0.141 | — | common-variant locus | no MR -> candidate analysis |
| angina pectoris | 0.092 | — | common-variant locus | no MR -> candidate analysis |
Of the 5 rows above, 5 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=NA, LOEUF=NA — Constraint metrics missing; LoF tolerance cannot be judged. |
| GWAS Catalog | 104 unique SNPs / 238 rows |
| ClinVar | 110 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 64 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘B3GNT8’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 110 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 22 traits by best p-value, aggregated from 33 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q67FW5 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000177191/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/B3GNT8 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/B3GNT8 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=B3GNT8%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/B3GNT8 — GWAS Catalog search API (live; release not exposed)