Protein Dossier — BCAN (Brevican core protein)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level |
1.01 |
0.27 |
1.86e-04 |
Wald ratio |
1 |
cis |
NA |
| Potassium in urine |
0.0461 |
0.0145 |
0.00149 |
Wald ratio |
1 |
cis |
NA |
| Creatinine (enzymatic) in urine |
0.0431 |
0.0137 |
0.00163 |
Wald ratio |
1 |
cis |
NA |
| Pancreatic cancer |
0.862 |
0.275 |
0.00171 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypertrophic cardiomyopathy (hcm or hocm) |
1.04 |
0.433 |
0.016 |
Wald ratio |
1 |
cis |
NA |
| Sodium in urine |
0.0336 |
0.0141 |
0.0169 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: asthma |
0.0796 |
0.037 |
0.0316 |
Wald ratio |
1 |
cis |
NA |
| Hippocampus volume |
-60.3 |
28.1 |
0.0318 |
Wald ratio |
1 |
cis |
NA |
| Thyroid cancer |
0.975 |
0.456 |
0.0323 |
Wald ratio |
1 |
cis |
NA |
| Microalbuminuria |
-0.254 |
0.119 |
0.0336 |
Wald ratio |
1 |
cis |
NA |
| Neuroblastoma |
-0.515 |
0.249 |
0.0387 |
Wald ratio |
1 |
cis |
NA |
| Type 2 diabetes |
-0.147 |
0.074 |
0.0468 |
Wald ratio |
1 |
cis |
NA |
| …and 99 more outcomes (see JSON) |
|
|
|
|
|
|
|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3461_58_1 |
PGCB |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
38 association rows across 28 traits (36 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating BCAN levels |
4e-298 |
rs2365715 |
3 |
GCST90859689 |
no MR -> candidate analysis |
| BCAN protein levels |
5e-292 |
rs2365715 |
1 |
GCST90468426 |
no MR -> candidate analysis |
| BCAN/NPTXR protein level ratio |
3e-155 |
rs3795736 |
1 |
GCST90313482 |
no MR -> candidate analysis |
| BCAN/DPP6 protein level ratio |
5e-148 |
rs3795736 |
1 |
GCST90313478 |
no MR -> candidate analysis |
| BCAN/CD200 protein level ratio |
9e-144 |
rs3795736 |
1 |
GCST90313477 |
no MR -> candidate analysis |
| BCAN/MOG protein level ratio |
2e-132 |
rs3795736 |
1 |
GCST90313480 |
no MR -> candidate analysis |
| BCAN/KLK6 protein level ratio |
1e-129 |
rs3795736 |
1 |
GCST90313479 |
no MR -> candidate analysis |
| HDGF protein levels |
7e-121 |
rs150063652 |
3 |
GCST90469442 |
no MR -> candidate analysis |
| Brevican core protein levels |
4e-73 |
rs2365715 |
5 |
GCST90425778 |
no MR -> candidate analysis |
| Serum levels of protein BCAN |
1e-31 |
rs2365715 |
2 |
GCST90088400 |
no MR -> candidate analysis |
| Brevican core protein level in Chronic kidney disease with h |
1e-27 |
rs113184515 |
1 |
GCST90237392 |
no MR -> candidate analysis |
| Brevican core protein levels (BCAN.3461.58.1) |
2e-26 |
rs41267397 |
2 |
GCST90240470 |
no MR -> candidate analysis |
| …and 16 more traits (see JSON) |
|
|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 160 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| chronic hepatitis |
0.271 |
— |
common-variant locus |
no MR -> candidate analysis |
| myopia |
0.182 |
— |
established (curated) |
no MR -> candidate analysis |
| pathological myopia |
0.182 |
— |
established (curated) |
no MR -> candidate analysis |
| Decreased total leukocyte count |
0.083 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 4 rows above, 4 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=3.7e-08, LOEUF=0.697 — LoF-tolerant |
| GWAS Catalog |
72 unique SNPs / 143 rows |
| ClinVar |
173 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 160 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘BCAN’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 173 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 28 traits by best p-value, aggregated from 38 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q96GW7 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000132692/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/BCAN — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/BCAN — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=BCAN%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/BCAN — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:16:07 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none