MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Pulse rate | -0.0637 | 0.0211 | 0.00252 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: hypertension | 0.0513 | 0.0194 | 0.00812 | Wald ratio | 1 | trans | NA |
| Paget’s disease | -0.676 | 0.29 | 0.0196 | Wald ratio | 1 | trans | NA |
| Urinary albumin-to-creatinine ratio | 0.0673 | 0.0288 | 0.0196 | Wald ratio | 1 | trans | NA |
| Thalamus volume | 68.4 | 30.5 | 0.0248 | Wald ratio | 1 | trans | NA |
| Cancer code self-reported: basal cell carcinoma | 0.222 | 0.101 | 0.0282 | Wald ratio | 1 | trans | NA |
| Years of schooling | -0.0385 | 0.0192 | 0.0455 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: deep venous thrombosis (dvt) | -0.211 | 0.106 | 0.0465 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level | 0.662 | 0.333 | 0.0465 | Wald ratio | 1 | trans | NA |
| Ferritin | -0.0899 | 0.0462 | 0.0514 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: pulmonary embolism (with or without) dvt | -0.403 | 0.209 | 0.0538 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: osteoarthritis | 0.0689 | 0.0374 | 0.0651 | Wald ratio | 1 | trans | NA |
| …and 105 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
65 association rows across 51 traits (51 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Mosaic loss of chromosome Y (Y chromosome dosage) | 3e-88 | rs2842873 | 3 | GCST009067 | no MR -> candidate analysis |
| Neutrophil count | 5e-70 | rs3768276 | 1 | GCST90101731 | no MR -> candidate analysis |
| White blood cell count | 3e-55 | rs3768276 | 1 | GCST90101726 | no MR -> candidate analysis |
| Height | 2e-33 | rs2758603 | 1 | GCST90245848 | no MR -> candidate analysis |
| Myeloproliferative neoplasms (MTAG) | 3e-24 | rs1052053 | 1 | GCST90428574 | no MR -> candidate analysis |
| Estimated glomerular filtration rate (cystatin c) | 9e-24 | rs1052053 | 1 | GCST90428448 | no MR -> candidate analysis |
| Estimated glomerular filtration rate (creatinine, cystatin c | 1e-23 | rs1052053 | 1 | GCST90428446 | no MR -> candidate analysis |
| Clear cell renal cell carcinoma | 2e-19 | rs2251636 | 1 | GCST90320055 | no MR -> candidate analysis |
| Serum creatinine levels | 1e-16 | rs2842870 | 2 | GCST90018979 | no MR -> candidate analysis |
| Estimated glomerular filtration rate (creatinine) | 2e-16 | rs2842870 | 2 | GCST90100220 | no MR -> candidate analysis |
| Average diameter for VLDL particles | 4e-15 | rs10908491 | 1 | GCST90501292 | no MR -> candidate analysis |
| estimated glomerular filtration rate (eGFR, minimum, inv-nor | 5e-15 | rs2842873 | 1 | GCST90479600 | no MR -> candidate analysis |
| …and 39 more traits (see JSON) |
Top diseases by Open Targets association (of 835 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| kidney failure | 0.523 | — | common-variant locus | no MR -> candidate analysis |
| thyroid gland carcinoma | 0.485 | — | common-variant locus | no MR -> candidate analysis |
| renal carcinoma | 0.446 | — | common-variant locus | no MR -> candidate analysis |
| clear cell renal carcinoma | 0.424 | — | common-variant locus | no MR -> candidate analysis |
| ischemic stroke | 0.414 | — | common-variant locus | MR: beta=-0.0933, p=0.24 (trans) |
| type 2 diabetes mellitus | 0.229 | — | common-variant locus | no MR -> candidate analysis |
| diabetes mellitus | 0.207 | — | common-variant locus | no MR -> candidate analysis |
| stroke disorder | 0.211 | — | common-variant locus | no MR -> candidate analysis |
| intracerebral hemorrhage | 0.217 | — | common-variant locus | no MR -> candidate analysis |
| cancer | 0.161 | — | common-variant locus | MR: beta=0.0513, p=0.00812 (trans) |
| hypertensive disorder | 0.162 | — | common-variant locus | no MR -> candidate analysis |
| small vessel stroke | 0.164 | — | common-variant locus | no MR -> candidate analysis |
| Alzheimer disease | 0.08 | — | common-variant locus | no MR -> candidate analysis |
| myeloproliferative disorder | 0.154 | — | common-variant locus | no MR -> candidate analysis |
| testicular germ cell tumor | 0.134 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=2.6e-06, LOEUF=1.68 — LoF-tolerant |
| GWAS Catalog | 103 unique SNPs / 210 rows |
| ClinVar | 50 records; 8 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 835 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘BGLAP’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 50 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 51 traits by best p-value, aggregated from 65 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P02818 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000242252/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/BGLAP — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/BGLAP — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=BGLAP%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/BGLAP — GWAS Catalog search API (live; release not exposed)