Protein Dossier — BPI (Bactericidal permeability-increasing protein)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Endometrioid ovarian cancer |
-0.142 |
0.0671 |
0.0346 |
Wald ratio |
1 |
cis |
NA |
| Clear cell ovarian cancer |
-0.195 |
0.0935 |
0.0373 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: D25 Leiomyoma of uterus |
-0.118 |
0.0572 |
0.0389 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N92 Excessive frequent and irregular menstruation |
-0.0903 |
0.0438 |
0.0393 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter |
-0.166 |
0.0813 |
0.0408 |
Wald ratio |
1 |
cis |
NA |
| Thalamus volume |
-29.1 |
14.4 |
0.0427 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: uterine fibroids |
-0.104 |
0.0516 |
0.0436 |
Wald ratio |
1 |
cis |
NA |
| Serum cystatin C (eGFRcys) |
0.00962 |
0.00497 |
0.0527 |
Wald ratio |
1 |
cis |
NA |
| Caudate volume |
21.3 |
11.2 |
0.0568 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K60 Fissure and fistula of anal and rectal regions |
0.14 |
0.0743 |
0.0602 |
Wald ratio |
1 |
cis |
NA |
| Systolic blood pressure automated reading |
-0.0108 |
0.00587 |
0.0653 |
Wald ratio |
1 |
cis |
NA |
| Fasting proinsulin |
-0.0341 |
0.0186 |
0.0668 |
Wald ratio |
1 |
cis |
NA |
| …and 85 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4126_22_1 |
BPI |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
55 association rows across 27 traits (50 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Bactericidal permeability-increasing protein levels |
5e-231 |
rs6127742 |
8 |
GCST90246731 |
no MR -> candidate analysis |
| Serum levels of protein BPI |
4e-180 |
rs1780617 |
4 |
GCST90088584 |
no MR -> candidate analysis |
| Blood protein levels |
9e-113 |
rs1780617 |
3 |
GCST006585 |
no MR -> candidate analysis |
| Serum levels of protein MUL1 |
9e-98 |
rs1780617 |
4 |
GCST90090625 |
no MR -> candidate analysis |
| Bactericidal permeability-increasing protein levels (BPI.412 |
1e-67 |
rs1780617 |
3 |
GCST90240373 |
no MR -> candidate analysis |
| LBP protein levels |
2e-37 |
rs1205422 |
4 |
GCST90469743 |
no MR -> candidate analysis |
| Lipopolysaccharide-binding protein levels |
3e-29 |
rs2232575 |
2 |
GCST90161628 |
no MR -> candidate analysis |
| Mitochondrial ubiquitin ligase activator of NFKB 1 levels (M |
4e-26 |
rs11086556 |
2 |
GCST90241945 |
no MR -> candidate analysis |
| RETN protein levels |
4e-25 |
rs6069597 |
1 |
GCST90470457 |
no MR -> candidate analysis |
| Circulating RETN levels |
1e-19 |
rs6064367 |
4 |
GCST90859950 |
no MR -> candidate analysis |
| Monocyte percentage (UKB data field 30190) |
3e-15 |
rs6123584 |
1 |
GCST90468091 |
no MR -> candidate analysis |
| Monocyte percentage of white cells |
7e-15 |
rs5743511 |
2 |
GCST90002394 |
no MR -> candidate analysis |
| …and 15 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 281 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| retinal degeneration |
0.463 |
— |
common-variant locus |
no MR -> candidate analysis |
| alcohol drinking |
0.407 |
— |
common-variant locus |
no MR -> candidate analysis |
| asthma |
0.395 |
— |
common-variant locus |
no MR -> candidate analysis |
| acute tonsillitis |
0.395 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 4 rows above, 4 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=3.4e-14, LOEUF=1.06 — LoF-tolerant |
| GWAS Catalog |
107 unique SNPs / 210 rows |
| ClinVar |
109 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 281 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘BPI’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 109 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 27 traits by best p-value, aggregated from 55 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P17213 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000101425/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/BPI — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/BPI — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=BPI%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/BPI — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:18:08 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none