MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Alcohol intake frequency | -0.0195 | 0.00695 | 0.00514 | Wald ratio | 1 | trans | NA |
| Glioma | -0.2 | 0.0843 | 0.0177 | Wald ratio | 1 | trans | NA |
| Cardioembolic stroke | 0.143 | 0.0621 | 0.0212 | Wald ratio | 1 | trans | NA |
| Cancer code self-reported: malignant melanoma | -0.14 | 0.0616 | 0.0233 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: D12 Benign neoplasm of colon rectum anus and anal canal | 0.0828 | 0.0366 | 0.0237 | Wald ratio | 1 | trans | NA |
| Depressive symptoms | -0.0165 | 0.00732 | 0.0244 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: arthritis (nos) | 0.101 | 0.0491 | 0.0394 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: hypertension | -0.0168 | 0.00815 | 0.0398 | Wald ratio | 1 | trans | NA |
| Bipolar disorder | 0.0933 | 0.0456 | 0.0406 | Wald ratio | 1 | trans | NA |
| Heel bone mineral density (BMD) T-score automated | -0.0123 | 0.00609 | 0.0431 | Wald ratio | 1 | trans | NA |
| Chronic kidney disease | -0.0586 | 0.0293 | 0.0455 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: Z09 Follow-up examination after treatment for conditions other than malignant neoplasms | 0.071 | 0.0357 | 0.0466 | Wald ratio | 1 | trans | NA |
| …and 80 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
30 association rows across 22 traits (29 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| CALB1 protein levels | 1e-83 | rs143241372 | 2 | GCST90468526 | no MR -> candidate analysis |
| DECR1/METAP1D protein level ratio | 4e-52 | rs117462290 | 1 | GCST90314448 | no MR -> candidate analysis |
| DECR1/MAP2K6 protein level ratio | 3e-40 | rs117462290 | 1 | GCST90314447 | no MR -> candidate analysis |
| DECR1/FXN protein level ratio | 1e-38 | rs117462290 | 1 | GCST90314446 | no MR -> candidate analysis |
| DECR1/PLXNA4 protein level ratio | 1e-37 | rs117462290 | 1 | GCST90314449 | no MR -> candidate analysis |
| BCR/DECR1 protein level ratio | 3e-36 | rs117462290 | 1 | GCST90313489 | no MR -> candidate analysis |
| DECR1/PRDX3 protein level ratio | 2e-35 | rs117462290 | 1 | GCST90314450 | no MR -> candidate analysis |
| CLPP/DECR1 protein level ratio | 1e-32 | rs117462290 | 1 | GCST90314137 | no MR -> candidate analysis |
| CLIP2/DECR1 protein level ratio | 4e-31 | rs117462290 | 1 | GCST90314126 | no MR -> candidate analysis |
| DECR1/STX4 protein level ratio | 7e-31 | rs117462290 | 1 | GCST90314451 | no MR -> candidate analysis |
| DECR1/STX8 protein level ratio | 1e-28 | rs117462290 | 1 | GCST90314452 | no MR -> candidate analysis |
| ATP5IF1/DECR1 protein level ratio | 6e-28 | rs117462290 | 1 | GCST90313382 | no MR -> candidate analysis |
| …and 10 more traits (see JSON) |
Top diseases by Open Targets association (of 1715 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| cutaneous melanoma | 0.471 | — | common-variant locus | no MR -> candidate analysis |
| kidney disorder | 0.462 | — | common-variant locus | no MR -> candidate analysis |
| stroke disorder | 0.407 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.407 | — | common-variant locus | no MR -> candidate analysis |
| gestational diabetes | 0.394 | — | common-variant locus | no MR -> candidate analysis |
| smoking initiation | 0.393 | — | common-variant locus | no MR -> candidate analysis |
| placental abruption | 0.367 | — | common-variant locus | no MR -> candidate analysis |
| liver disorder | 0.347 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.258 | — | common-variant locus | no MR -> candidate analysis |
| attention deficit-hyperactivity disorder | 0.246 | — | common-variant locus | no MR -> candidate analysis |
| substance abuse | 0.246 | — | common-variant locus | no MR -> candidate analysis |
| nervous system disorder | 0.22 | — | common-variant locus | no MR -> candidate analysis |
| Alzheimer disease | 0.054 | — | common-variant locus | no MR -> candidate analysis |
Of the 13 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.95, LOEUF=0.521 — LoF-INTOLERANT |
| GWAS Catalog | 48 unique SNPs / 85 rows |
| ClinVar | 62 records; 6 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 1715 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CALB1’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 62 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 22 traits by best p-value, aggregated from 30 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P05937 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000104327/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CALB1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CALB1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CALB1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CALB1 — GWAS Catalog search API (live; release not exposed)