Protein Dossier — CAPG (Condensin complex subunit 3)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Hearing difficulty or problems: Yes |
-0.0544 |
0.0141 |
1.18e-04 |
Wald ratio |
1 |
cis |
NA |
| Forced vital capacity (FVC) |
-0.0184 |
0.00636 |
0.00376 |
Wald ratio |
1 |
cis |
NA |
| Pulse rate |
0.0381 |
0.0137 |
0.00542 |
Wald ratio |
1 |
cis |
NA |
| Body mass index (BMI) |
0.0215 |
0.00776 |
0.00558 |
Wald ratio |
1 |
cis |
NA |
| Forced expiratory volume in 1-second (FEV1) |
-0.0171 |
0.00671 |
0.011 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N40 Hyperplasia of prostate |
-0.252 |
0.105 |
0.0166 |
Wald ratio |
1 |
cis |
NA |
| Amygdala volume |
-22.8 |
10.1 |
0.0239 |
Wald ratio |
1 |
cis |
NA |
| Pallidum volume |
-15.5 |
7.59 |
0.0414 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypertension |
0.0259 |
0.0129 |
0.0442 |
Wald ratio |
1 |
cis |
NA |
| Nucleus accumbens volume |
-9.21 |
4.66 |
0.0481 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K20 Oesophagitis |
0.132 |
0.069 |
0.0556 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: asthma |
0.039 |
0.0209 |
0.0626 |
Wald ratio |
1 |
cis |
NA |
| …and 72 more outcomes (see JSON) |
|
|
|
|
|
|
|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4968_50_1 |
CAPG |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
37 association rows across 13 traits (37 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| AMBP/CAPG protein level ratio |
2e-4277 |
rs6886 |
1 |
GCST90313252 |
no MR -> candidate analysis |
| Circulating CAPG levels |
2e-789 |
rs2002444 |
3 |
GCST90860271 |
no MR -> candidate analysis |
| CAPG protein levels |
7e-301 |
rs75000263 |
7 |
GCST90468537 |
no MR -> candidate analysis |
| Macrophage-capping protein levels |
3e-207 |
rs62623452 |
4 |
GCST90248382 |
no MR -> candidate analysis |
| TGOLN2 protein levels |
2e-143 |
rs11681965 |
14 |
GCST90470850 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein CAPG levels |
9e-90 |
rs6886 |
1 |
GCST90943116 |
no MR -> candidate analysis |
| platelet count (minimum, inv-norm transformed) |
2e-25 |
rs62162752 |
1 |
GCST90480652 |
no MR -> candidate analysis |
| platelet count (mean, inv-norm transformed) |
3e-25 |
rs62162752 |
1 |
GCST90480651 |
no MR -> candidate analysis |
| Platelet count |
7e-18 |
rs3770102 |
1 |
GCST90662907 |
no MR -> candidate analysis |
| platelet count (maximum, inv-norm transformed) |
1e-17 |
rs62162752 |
1 |
GCST90480650 |
no MR -> candidate analysis |
| Serum levels of protein CAPG |
1e-10 |
rs35666320 |
1 |
GCST90088833 |
no MR -> candidate analysis |
| Diastolic blood pressure (MTAG) |
2e-9 |
rs111384899 |
1 |
GCST90449057 |
no MR -> candidate analysis |
| …and 1 more traits (see JSON) |
|
|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 207 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Sensorineural hearing impairment |
0.584 |
— |
common-variant locus |
no MR -> candidate analysis |
| cerebral atherosclerosis |
0.041 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 2 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Macrophage-capping protein) |
| gnomAD constraint |
pLI=2e-08, LOEUF=0.964 — LoF-tolerant |
| GWAS Catalog |
111 unique SNPs / 256 rows |
| ClinVar |
89 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
1 clinical annotations across 1 drugs |
phenome — Top 30 of 207 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘CAPG’ and resolved to ‘Macrophage-capping protein’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 89 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 13 of 13 traits by best p-value, aggregated from 37 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9BPX3 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000042493/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL6066906/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/CAPG — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CAPG — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CAPG%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=CAPG — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/CAPG — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:27:36 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none