MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Non-cancer illness code self-reported: arthritis (nos) | 0.124 | 0.0334 | 2.11e-04 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: B37 Candidiasis | 0.355 | 0.111 | 0.00138 | Wald ratio | 1 | cis | NA |
| Fractured bone site(s): Wrist | 0.0631 | 0.022 | 0.00408 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: Z09 Follow-up examination after treatment for conditions other than malignant neoplasms | 0.0624 | 0.0251 | 0.0128 | Wald ratio | 1 | cis | NA |
| Pallidum volume | 5.67 | 2.56 | 0.0267 | Wald ratio | 1 | cis | NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | -0.0197 | 0.00935 | 0.035 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: pulmonary embolism (with or without) dvt | -0.08 | 0.0394 | 0.0424 | Wald ratio | 1 | cis | NA |
| ER-negative Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | -0.0329 | 0.0164 | 0.0449 | Wald ratio | 1 | cis | NA |
| Weight | 0.0058 | 0.00289 | 0.0453 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: iron deficiency anaemia | 0.0821 | 0.0414 | 0.0477 | Wald ratio | 1 | cis | NA |
| Endometrioid ovarian cancer | 0.0809 | 0.041 | 0.0489 | Wald ratio | 1 | cis | NA |
| ER-positive Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | -0.0214 | 0.011 | 0.0522 | Wald ratio | 1 | cis | NA |
| …and 70 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
12 association rows across 12 traits (6 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| GLIPR1 protein levels | 9e-12 | rs146606540 | 1 | GCST90469357 | no MR -> candidate analysis |
| Ease of getting up in the morning | 2e-11 | rs1420607 | 1 | GCST007986 | no MR -> candidate analysis |
| Eczema | 3e-11 | rs41190 | 1 | GCST007075 | no MR -> candidate analysis |
| Neurofibrillary tangles (SNP x SNP interaction) | 1e-9 | rs1954455 x rs4785162 | 1 | GCST010343 | no MR -> candidate analysis |
| Allergic rhinitis | 4e-9 | rs12920150 | 1 | GCST009719 | MR: beta=-0.0219, p=0.112 (cis) |
| Body mass index | 2e-8 | rs3833063 | 1 | GCST90255621 | MR: beta=0.00593, p=0.0702 (cis) |
| AUC at steady-state of apixaban | 2e-7 | rs59884489 | 1 | GCST90225999 | no MR -> candidate analysis |
| Social autistic-like traits | 2e-6 | rs16946931 | 1 | GCST002228 | no MR -> candidate analysis |
| Cmin at steady-state of apixaban | 2e-6 | rs59884489 | 1 | GCST90226001 | no MR -> candidate analysis |
| CDCP1 levels | 2e-6 | rs4785279 | 1 | GCST90503354 | no MR -> candidate analysis |
| Chronic renal failure [CKD] (PheCode 585.3) | 8e-6 | rs565027569 | 1 | GCST90651114 | no MR -> candidate analysis |
| Cmax at steady-state of apixaban | 8e-6 | rs59884489 | 1 | GCST90226000 | no MR -> candidate analysis |
Top diseases by Open Targets association (of 972 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| alcohol drinking | 0.591 | — | common-variant locus | no MR -> candidate analysis |
| obesity disorder | 0.511 | — | common-variant locus | no MR -> candidate analysis |
| diabetes mellitus | 0.44 | — | common-variant locus | no MR -> candidate analysis |
| type 2 diabetes mellitus | 0.385 | — | common-variant locus | no MR -> candidate analysis |
| preeclampsia | 0.248 | — | common-variant locus | no MR -> candidate analysis |
| cholelithiasis | 0.249 | — | common-variant locus | no MR -> candidate analysis |
| allergic rhinitis | 0.249 | — | common-variant locus | MR: beta=-0.0219, p=0.112 (cis) |
| deep vein thrombosis | 0.234 | — | common-variant locus | no MR -> candidate analysis |
| Eczematoid dermatitis | 0.228 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.228 | — | common-variant locus | no MR -> candidate analysis |
| rhinitis | 0.228 | — | common-variant locus | MR: beta=-0.0219, p=0.112 (cis) |
| type 1 diabetes mellitus | 0.213 | — | common-variant locus | no MR -> candidate analysis |
| central nervous system infectious disorder | 0.192 | — | common-variant locus | no MR -> candidate analysis |
| myeloid leukemia | 0.178 | — | common-variant locus | no MR -> candidate analysis |
Of the 14 rows above, 12 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.75, LOEUF=0.662 — LoF-tolerant |
| GWAS Catalog | 25 unique SNPs / 45 rows |
| ClinVar | 41 records; 8 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 972 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CBLN1’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 41 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 12 of 12 traits by best p-value, aggregated from 12 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P23435 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000102924/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CBLN1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CBLN1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CBLN1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CBLN1 — GWAS Catalog search API (live; release not exposed)