MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Schizophrenia | -0.0503 | 0.0143 | 4.26e-04 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: osteoarthritis | 0.0369 | 0.0106 | 4.81e-04 | Wald ratio | 1 | cis | NA |
| Packed cell volume | 0.076 | 0.024 | 0.0015 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M23 Internal derangement of knee | 0.0589 | 0.0208 | 0.00458 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypertension | 0.0153 | 0.0055 | 0.00539 | Wald ratio | 1 | cis | NA |
| Systemic lupus erythematosus | 0.171 | 0.063 | 0.00659 | Wald ratio | 1 | cis | NA |
| Knee and hip osteoarthritis | -0.0763 | 0.0285 | 0.00745 | Wald ratio | 1 | cis | NA |
| Height | -0.00982 | 0.00406 | 0.0155 | Wald ratio | 1 | cis | NA |
| Thalamus volume | 20.2 | 8.39 | 0.0158 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K57 Diverticular disease of intestine | -0.0561 | 0.0244 | 0.0216 | Wald ratio | 1 | cis | NA |
| Nucleus accumbens volume | 3.23 | 1.45 | 0.0257 | Wald ratio | 1 | cis | NA |
| PGC cross-disorder traits | -0.0361 | 0.0164 | 0.0272 | Wald ratio | 1 | cis | NA |
| …and 115 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
33 association rows across 21 traits (27 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Carbonyl reductase [NADPH] 3 levels | 4e-387 | rs60043102 | 3 | GCST90246885 | no MR -> candidate analysis |
| Serum levels of protein CBR3 | 6e-286 | rs12483755 | 2 | GCST90087775 | no MR -> candidate analysis |
| Carbonyl reductase [NADPH] 3 levels (CBR3.14091.42.3) | 3e-259 | rs1028997 | 3 | GCST90240594 | no MR -> candidate analysis |
| Blood protein levels | 3e-160 | rs60409141 | 1 | GCST006585 | no MR -> candidate analysis |
| Height | 5e-48 | rs8133052 | 3 | GCST90245848 | MR: beta=-0.00982, p=0.0155 (cis) |
| Insulin-like growth factor 1 levels | 2e-42 | rs9636630 | 2 | GCST90019511 | no MR -> candidate analysis |
| Cerebrospinal fluid protein CBR3 levels | 8e-39 | rs1056892 | 1 | GCST90940678 | no MR -> candidate analysis |
| Carbonyl reductase [NADPH] 3 level in Chronic kidney disease | 4e-24 | rs7283498 | 1 | GCST90234182 | no MR -> candidate analysis |
| C-reactive protein levels | 2e-12 | rs7280982 | 1 | GCST009777 | no MR -> candidate analysis |
| Prostate cancer | 8e-12 | rs2242798 | 2 | GCST90274713 | MR: beta=-0.0599, p=0.142 (cis) |
| Free Cholesterol to Total Lipids in Very Large VLDL percenta | 1e-10 | rs113357683 | 1 | GCST90501311 | no MR -> candidate analysis |
| GH3 domain-containing protein protein levels (SomaScan ID:14 | 2e-9 | rs1028997 | 1 | GCST90439593 | no MR -> candidate analysis |
| …and 9 more traits (see JSON) |
Top diseases by Open Targets association (of 123 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| prostate carcinoma | 0.561 | — | common-variant locus | no MR -> candidate analysis |
| escherichia coli infection | 0.544 | — | common-variant locus | no MR -> candidate analysis |
| frozen shoulder | 0.355 | — | common-variant locus | no MR -> candidate analysis |
| facial morphology | 0.099 | — | common-variant locus | no MR -> candidate analysis |
| Burkitt lymphoma | 0.092 | — | common-variant locus | no MR -> candidate analysis |
| femoral neck fracture | 0.081 | — | common-variant locus | no MR -> candidate analysis |
| stomach disorder | 0.065 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.053 | — | common-variant locus | no MR -> candidate analysis |
| Left bundle branch block | 0.046 | — | common-variant locus | no MR -> candidate analysis |
Of the 9 rows above, 9 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Carbonyl reductase [NADPH] 3) |
| gnomAD constraint | pLI=2.8e-06, LOEUF=1.88 — LoF-tolerant |
| GWAS Catalog | 53 unique SNPs / 112 rows |
| ClinVar | 127 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | 4 clinical annotations across 5 drugs |
phenome — Top 30 of 123 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘CBR3’ and resolved to ‘Carbonyl reductase [NADPH] 3’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 127 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 21 traits by best p-value, aggregated from 33 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/O75828 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000159231/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL6008/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/CBR3 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CBR3 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CBR3%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=CBR3 — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/CBR3 — GWAS Catalog search API (live; release not exposed)