Protein Dossier — CCL11 (Eotaxin)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Percent emphysema |
-0.158 |
0.093 |
0.0892 |
Wald ratio |
1 |
trans |
NA |
| Primary sclerosing cholangitis |
0.238 |
0.153 |
0.12 |
Wald ratio |
1 |
trans |
NA |
| Hirschsprung’s disease |
-1.66 |
1.14 |
0.147 |
Wald ratio |
1 |
trans |
NA |
| Gallbladder cancer |
1.37 |
1.61 |
0.392 |
Wald ratio |
1 |
trans |
NA |
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5301_7_3 |
Eotaxin |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
29 association rows across 18 traits (26 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| CCL13/CCL8 protein level ratio |
9e-495 |
rs11652256 |
1 |
GCST90313676 |
no MR -> candidate analysis |
| CCL13 protein levels |
7e-95 |
rs1233650 |
1 |
GCST90468565 |
no MR -> candidate analysis |
| CCL8 protein levels |
1e-66 |
rs184953165 |
7 |
GCST90468586 |
no MR -> candidate analysis |
| Circulating CCL11 levels (id: OID00505_OID20668) |
3e-61 |
rs79722574 |
2 |
GCST90859861 |
no MR -> candidate analysis |
| Circulating CCL11 levels (id: OID00970_OID20668) |
5e-47 |
rs79722574 |
2 |
GCST90860201 |
no MR -> candidate analysis |
| Circulating CCL7 levels (id: OID00474_OID20523) |
2e-42 |
rs3091323 |
1 |
GCST90859834 |
no MR -> candidate analysis |
| Circulating CCL7 levels (id: OID00755_OID20523) |
4e-32 |
rs3091323 |
1 |
GCST90860091 |
no MR -> candidate analysis |
| Blood protein levels |
2e-30 |
rs2215184 |
1 |
GCST010104 |
no MR -> candidate analysis |
| C-C motif chemokine 7 levels |
3e-24 |
rs16969454 |
1 |
GCST90162169 |
no MR -> candidate analysis |
| CCL7 protein levels |
2e-22 |
rs1233653 |
2 |
GCST90428425 |
no MR -> candidate analysis |
| Circulating CCL13 levels (id: OID00504_OID20655) |
2e-21 |
rs202247332 |
1 |
GCST90859860 |
no MR -> candidate analysis |
| Circulating CCL13 levels (id: OID00768_OID20655) |
2e-17 |
rs202247332 |
1 |
GCST90860103 |
no MR -> candidate analysis |
| …and 6 more traits (see JSON) |
|
|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 821 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| inflammatory bowel disease |
0.471 |
— |
common-variant locus |
no MR -> candidate analysis |
| vertebral column disorder |
0.375 |
— |
common-variant locus |
no MR -> candidate analysis |
| psoriasis |
0.26 |
— |
common-variant locus |
no MR -> candidate analysis |
| hyperpituitarism |
0.244 |
— |
common-variant locus |
no MR -> candidate analysis |
| ulcerative colitis |
0.089 |
— |
common-variant locus |
no MR -> candidate analysis |
| Apnea |
0.137 |
— |
common-variant locus |
no MR -> candidate analysis |
| Crohn disease |
0.111 |
— |
common-variant locus |
no MR -> candidate analysis |
| colitis |
0.053 |
— |
common-variant locus |
no MR -> candidate analysis |
| drug allergy |
0.117 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 9 rows above, 9 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
1 known modulators (Eotaxin) |
| gnomAD constraint |
pLI=0.0027, LOEUF=1.81 — LoF-tolerant |
| GWAS Catalog |
104 unique SNPs / 212 rows |
| ClinVar |
41 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
1 clinical annotations across 1 drugs |
phenome — Top 30 of 821 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘CCL11’ and resolved to ‘Eotaxin’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 41 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 18 of 18 traits by best p-value, aggregated from 29 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P51671 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000172156/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3286077/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/CCL11 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CCL11 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CCL11%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=CCL11 — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/CCL11 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:30:42 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none