Protein Dossier — CCL14 (C-C motif chemokine 14)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Melanoma |
0.234 |
0.102 |
0.0217 |
Wald ratio |
1 |
cis |
NA |
| Anorexia nervosa |
0.1 |
0.0512 |
0.0503 |
Wald ratio |
1 |
cis |
NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) |
-0.0246 |
0.0126 |
0.0504 |
Inverse variance weighted |
2 |
trans |
NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) |
-0.0246 |
0.0126 |
0.0504 |
Inverse variance weighted |
2 |
cis |
NA |
| Non-cancer illness code self-reported: gout |
-0.0892 |
0.0469 |
0.0573 |
Inverse variance weighted |
2 |
trans |
NA |
| Non-cancer illness code self-reported: gout |
-0.0892 |
0.0469 |
0.0573 |
Inverse variance weighted |
2 |
cis |
NA |
| Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level |
0.375 |
0.212 |
0.0771 |
Inverse variance weighted |
2 |
trans |
NA |
| Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level |
0.375 |
0.212 |
0.0771 |
Inverse variance weighted |
2 |
cis |
NA |
| Platelet count |
1.25 |
0.705 |
0.0775 |
Inverse variance weighted |
2 |
trans |
NA |
| Platelet count |
1.25 |
0.705 |
0.0775 |
Inverse variance weighted |
2 |
cis |
NA |
| Urate |
0.0191 |
0.011 |
0.0829 |
Inverse variance weighted |
2 |
trans |
NA |
| Urate |
0.0191 |
0.011 |
0.0829 |
Inverse variance weighted |
2 |
cis |
NA |
| …and 151 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2900_53_3 |
HCC-1 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
139 association rows across 61 traits (132 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating CCL15 levels |
2e-5134 |
rs854624 |
3 |
GCST90859974 |
no MR -> candidate analysis |
| CCL14/CCL23 protein level ratio |
8e-1578 |
rs72830000 |
1 |
GCST90313678 |
no MR -> candidate analysis |
| C-C motif chemokine 15 levels |
3e-1432 |
rs854628 |
12 |
GCST90246903 |
no MR -> candidate analysis |
| CCL15/CCL23 protein level ratio |
4e-1384 |
rs75238886 |
1 |
GCST90313681 |
no MR -> candidate analysis |
| CCL14/CST3 protein level ratio |
1e-1319 |
rs72830000 |
1 |
GCST90313679 |
no MR -> candidate analysis |
| Circulating CCL14 levels |
5e-1269 |
rs9892586 |
2 |
GCST90860489 |
no MR -> candidate analysis |
| Circulating CCL23 levels (id: OID00530_OID20693) |
2e-1094 |
rs712048 |
3 |
GCST90859884 |
no MR -> candidate analysis |
| Circulating CCL23 levels (id: OID00811_OID20693) |
2e-846 |
rs712048 |
3 |
GCST90860141 |
no MR -> candidate analysis |
| C-C motif chemokine 14 levels |
2e-763 |
rs7222922 |
10 |
GCST90246902 |
no MR -> candidate analysis |
| C-C motif chemokine 15 levels (CCL15.14109.15.3) |
3e-411 |
rs854624 |
1 |
GCST90240483 |
no MR -> candidate analysis |
| Ck-beta-8-1 levels |
9e-326 |
rs712048 |
3 |
GCST90247039 |
no MR -> candidate analysis |
| Serum levels of protein CCL15 |
3e-293 |
rs41508645 |
1 |
GCST90088428 |
no MR -> candidate analysis |
| …and 49 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 134 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Raynaud disease |
0.035 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 1 rows above, 1 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=0.0012, LOEUF=1.76 — LoF-tolerant |
| GWAS Catalog |
151 unique SNPs / 378 rows |
| ClinVar |
26 records; 8 pathogenic in sample of 26 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 134 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CCL14’.clinvar — Pathogenic count is over the 26 record(s) retrieved, NOT over all 26 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 61 traits by best p-value, aggregated from 139 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q16627 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000276409/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CCL14 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CCL14 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CCL14%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CCL14 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:30:59 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none