Protein Dossier — CCL15 (C-C motif chemokine 15)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Subjective well being |
-0.0124 |
0.00414 |
0.0027 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: asthma |
-0.0225 |
0.00769 |
0.00344 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: mania or bipolar disorder or manic depression |
0.13 |
0.0463 |
0.00501 |
Wald ratio |
1 |
cis |
NA |
| Schizophrenia |
-0.0294 |
0.011 |
0.00753 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter |
-0.0889 |
0.0349 |
0.0109 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: D12 Benign neoplasm of colon rectum anus and anal canal |
0.0542 |
0.0215 |
0.0115 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: gastro-oesophageal reflux (gord) or gastric reflux |
0.0314 |
0.0125 |
0.012 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: bladder problem (not cancer) |
-0.0915 |
0.0386 |
0.0178 |
Wald ratio |
1 |
cis |
NA |
| Sleep duration |
-0.00481 |
0.00209 |
0.0216 |
Wald ratio |
1 |
cis |
NA |
| Intracranial volume |
-4.66e+03 |
2.11e+03 |
0.027 |
Wald ratio |
1 |
cis |
NA |
| Height |
0.0195 |
0.00887 |
0.0278 |
Wald ratio |
1 |
cis |
NA |
| Serum creatinine (eGFRcrea) |
-0.00231 |
0.00106 |
0.0303 |
Wald ratio |
1 |
cis |
NA |
| …and 101 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3509_1_1 |
MIP-5 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
135 association rows across 61 traits (130 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating CCL15 levels |
2e-5134 |
rs854624 |
3 |
GCST90859974 |
no MR -> candidate analysis |
| CCL14/CCL23 protein level ratio |
8e-1578 |
rs72830000 |
1 |
GCST90313678 |
no MR -> candidate analysis |
| C-C motif chemokine 15 levels |
3e-1432 |
rs854628 |
11 |
GCST90246903 |
no MR -> candidate analysis |
| CCL15/CCL23 protein level ratio |
4e-1384 |
rs75238886 |
1 |
GCST90313681 |
no MR -> candidate analysis |
| CCL14/CST3 protein level ratio |
1e-1319 |
rs72830000 |
1 |
GCST90313679 |
no MR -> candidate analysis |
| Circulating CCL14 levels |
5e-1269 |
rs9892586 |
2 |
GCST90860489 |
no MR -> candidate analysis |
| Circulating CCL23 levels (id: OID00530_OID20693) |
2e-1094 |
rs712048 |
3 |
GCST90859884 |
no MR -> candidate analysis |
| Circulating CCL23 levels (id: OID00811_OID20693) |
2e-846 |
rs712048 |
3 |
GCST90860141 |
no MR -> candidate analysis |
| C-C motif chemokine 14 levels |
2e-763 |
rs7222922 |
10 |
GCST90246902 |
no MR -> candidate analysis |
| C-C motif chemokine 15 levels (CCL15.14109.15.3) |
3e-411 |
rs854624 |
1 |
GCST90240483 |
no MR -> candidate analysis |
| Ck-beta-8-1 levels |
9e-326 |
rs712048 |
3 |
GCST90247039 |
no MR -> candidate analysis |
| Serum levels of protein CCL15 |
3e-293 |
rs41508645 |
1 |
GCST90088428 |
no MR -> candidate analysis |
| …and 49 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
No genetically-associated diseases retrieved from Open Targets.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=0.0047, LOEUF=1.36 — LoF-tolerant |
| GWAS Catalog |
165 unique SNPs / 400 rows |
| ClinVar |
25 records; 8 pathogenic in sample of 25 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 242 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CCL15’.clinvar — Pathogenic count is over the 25 record(s) retrieved, NOT over all 25 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 61 traits by best p-value, aggregated from 135 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q16663 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000275718/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CCL15 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CCL15 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CCL15%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CCL15 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:31:16 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none