Protein Dossier — CCL16 (C-C motif chemokine 16)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: hypopituitarism |
0.323 |
0.108 |
0.00286 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R35 Polyuria |
-0.119 |
0.0492 |
0.016 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: osteoporosis |
0.0483 |
0.0208 |
0.0205 |
Wald ratio |
1 |
cis |
NA |
| Alcohol intake frequency |
-0.00898 |
0.00403 |
0.0257 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: pulmonary embolism (with or without) dvt |
-0.0723 |
0.0325 |
0.026 |
Wald ratio |
1 |
cis |
NA |
| Thalamus volume |
16.7 |
7.83 |
0.0325 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: uterine fibroids |
-0.0478 |
0.0231 |
0.0383 |
Wald ratio |
1 |
cis |
NA |
| Hippocampus volume |
12 |
5.89 |
0.0424 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: G47 Sleep disorders |
-0.0778 |
0.0384 |
0.043 |
Wald ratio |
1 |
cis |
NA |
| Endometrioid ovarian cancer |
-0.0703 |
0.0354 |
0.047 |
Wald ratio |
1 |
cis |
NA |
| Lumbar spine bone mineral density |
-0.0206 |
0.0104 |
0.0478 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: chronic obstructive airways disease or copd |
-0.0992 |
0.0517 |
0.0548 |
Wald ratio |
1 |
cis |
NA |
| …and 67 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4913_78_1 |
HCC-4 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
63 association rows across 36 traits (55 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating CCL16 levels |
9e-5290 |
rs112689088 |
3 |
GCST90859998 |
no MR -> candidate analysis |
| C-C motif chemokine 16 levels |
6e-1527 |
rs10445391 |
8 |
GCST90246904 |
no MR -> candidate analysis |
| C-C motif chemokine 16 levels (CCL16.4913.78.1) |
3e-450 |
rs112689088 |
2 |
GCST90240485 |
no MR -> candidate analysis |
| Cystatin-8 levels |
5e-398 |
rs10445391 |
1 |
GCST90247215 |
no MR -> candidate analysis |
| NKG2-E type II integral membrane protein levels |
7e-380 |
rs10445391 |
1 |
GCST90248688 |
no MR -> candidate analysis |
| Serum levels of protein KLRC3 |
9e-276 |
rs112689088 |
1 |
GCST90089837 |
no MR -> candidate analysis |
| CCL16 protein levels |
2e-259 |
rs1635272 |
7 |
GCST90468568 |
no MR -> candidate analysis |
| Blood protein levels |
9e-198 |
rs10445391 |
7 |
GCST006585 |
no MR -> candidate analysis |
| Serum levels of protein CST8 |
4e-188 |
rs112689088 |
1 |
GCST90086348 |
no MR -> candidate analysis |
| Cystatin-8 levels (CST8.10572.65.3) |
6e-186 |
rs112689088 |
1 |
GCST90240830 |
no MR -> candidate analysis |
| Circulating CCL14 levels |
1e-180 |
rs57450479 |
1 |
GCST90860489 |
no MR -> candidate analysis |
| CCL14 protein levels |
7e-167 |
rs71366493 |
2 |
GCST90468566 |
no MR -> candidate analysis |
| …and 24 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 138 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Raynaud disease |
0.042 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 1 rows above, 1 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=0.011, LOEUF=1.57 — LoF-tolerant |
| GWAS Catalog |
156 unique SNPs / 376 rows |
| ClinVar |
33 records; 5 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 138 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CCL16’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 33 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 36 traits by best p-value, aggregated from 63 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/O15467 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000275152/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CCL16 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CCL16 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CCL16%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CCL16 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:31:35 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none