Protein Dossier — CCL17 (C-C motif chemokine 17)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Rheumatoid arthritis |
0.102 |
0.0386 |
0.00851 |
Inverse variance weighted |
2 |
trans |
NA |
| Rheumatoid arthritis |
0.102 |
0.0386 |
0.00851 |
Inverse variance weighted |
2 |
trans |
NA |
| Anorexia nervosa |
0.218 |
0.0845 |
0.00983 |
Inverse variance weighted |
2 |
trans |
NA |
| Anorexia nervosa |
0.218 |
0.0845 |
0.00983 |
Inverse variance weighted |
2 |
trans |
NA |
| Non-cancer illness code self-reported: gastro-oesophageal reflux (gord) or gastric reflux |
0.00299 |
0.00119 |
0.0117 |
Inverse variance weighted |
2 |
trans |
NA |
| Non-cancer illness code self-reported: gastro-oesophageal reflux (gord) or gastric reflux |
0.00299 |
0.00119 |
0.0117 |
Inverse variance weighted |
2 |
trans |
NA |
| Systemic lupus erythematosus |
0.272 |
0.114 |
0.0172 |
Inverse variance weighted |
2 |
trans |
NA |
| Systemic lupus erythematosus |
0.272 |
0.114 |
0.0172 |
Inverse variance weighted |
2 |
trans |
NA |
| Ischemic stroke |
-0.081 |
0.0373 |
0.03 |
Inverse variance weighted |
2 |
trans |
NA |
| Ischemic stroke |
-0.081 |
0.0373 |
0.03 |
Inverse variance weighted |
2 |
trans |
NA |
| Red blood cell count |
-0.0116 |
0.00576 |
0.0444 |
Inverse variance weighted |
2 |
trans |
NA |
| Red blood cell count |
-0.0116 |
0.00576 |
0.0444 |
Inverse variance weighted |
2 |
trans |
NA |
| …and 183 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3519_3_2 |
TARC |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
27 association rows across 17 traits (26 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating CCL17 levels (id: OID00439_OID20745) |
2e-450 |
rs9302690 |
2 |
GCST90859799 |
no MR -> candidate analysis |
| CCL17 protein levels |
2e-279 |
rs9302690 |
2 |
GCST90468569 |
no MR -> candidate analysis |
| Circulating CCL17 levels (id: OID00821_OID20745) |
8e-261 |
rs9302690 |
2 |
GCST90860150 |
no MR -> candidate analysis |
| CCL17/CCL22 protein level ratio |
3e-133 |
rs801506 |
1 |
GCST90313682 |
no MR -> candidate analysis |
| C-C motif chemokine 17 levels |
1e-78 |
rs16956811 |
6 |
GCST90246905 |
no MR -> candidate analysis |
| Serum levels of protein CCL17 |
9e-49 |
rs4396523 |
2 |
GCST90088432 |
no MR -> candidate analysis |
| Blood protein levels |
6e-30 |
rs16956811 |
1 |
GCST006585 |
no MR -> candidate analysis |
| Thymus and reactivation regulated chemokine levels |
3e-29 |
rs223896 |
1 |
GCST011913 |
no MR -> candidate analysis |
| Fractalkine levels |
3e-27 |
rs62037103 |
1 |
GCST90247635 |
no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) |
7e-26 |
rs60679405 |
1 |
GCST90838669 |
no MR -> candidate analysis |
| C-C motif chemokine 17 levels (CCL17.3519.3.2) |
2e-21 |
rs113022368 |
1 |
GCST90240486 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein CCL17 levels |
2e-20 |
rs223896 |
1 |
GCST90944147 |
no MR -> candidate analysis |
| …and 5 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 531 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| cardiomyopathy |
0.36 |
— |
common-variant locus |
MR: beta=0.000116, p=0.173 (trans) |
| systemic lupus erythematosus |
0.216 |
— |
common-variant locus |
MR: beta=0.272, p=0.0172 (trans) |
Of the 2 rows above, 0 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (C-C motif chemokine 17) |
| gnomAD constraint |
pLI=0.00075, LOEUF=1.96 — LoF-tolerant |
| GWAS Catalog |
67 unique SNPs / 134 rows |
| ClinVar |
49 records; 11 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 531 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘CCL17’ and resolved to ‘C-C motif chemokine 17’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 49 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 17 of 17 traits by best p-value, aggregated from 27 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q92583 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000102970/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4295915/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/CCL17 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CCL17 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CCL17%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CCL17 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:31:54 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none