Protein Dossier — CCL18 (C-C motif chemokine 18)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Diagnoses - main ICD10: G47 Sleep disorders |
-0.181 |
0.0712 |
0.0108 |
Wald ratio |
1 |
cis |
NA |
| Rheumatoid arthritis |
-0.0717 |
0.0282 |
0.0109 |
Wald ratio |
1 |
cis |
NA |
| Eczema |
0.0805 |
0.0317 |
0.011 |
Wald ratio |
1 |
cis |
NA |
| Neo-openness to experience |
-0.317 |
0.128 |
0.0136 |
Wald ratio |
1 |
cis |
NA |
| Amyotrophic lateral sclerosis |
0.0786 |
0.0323 |
0.0149 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Wrist |
-0.0803 |
0.035 |
0.022 |
Wald ratio |
1 |
cis |
NA |
| Pallidum volume |
-7.87 |
3.44 |
0.0222 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: J33 Nasal polyp |
-0.168 |
0.0783 |
0.0317 |
Wald ratio |
1 |
cis |
NA |
| Forearm bone mineral density |
0.0581 |
0.0285 |
0.0417 |
Wald ratio |
1 |
cis |
NA |
| Alzheimer’s disease |
0.0558 |
0.0287 |
0.0519 |
Wald ratio |
1 |
cis |
NA |
| Intracranial volume |
-6.54e+03 |
3.46e+03 |
0.0585 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R11 Nausea and vomiting |
-0.158 |
0.0851 |
0.063 |
Wald ratio |
1 |
cis |
NA |
| …and 82 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3044_3_2 |
PARC |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
89 association rows across 43 traits (85 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating CCL18 levels |
9e-1471 |
rs2015086 |
2 |
GCST90860473 |
no MR -> candidate analysis |
| ANG/CCL18 protein level ratio |
7e-1018 |
rs56683451 |
1 |
GCST90313258 |
no MR -> candidate analysis |
| CCL18/RARRES2 protein level ratio |
2e-1001 |
rs56683451 |
1 |
GCST90313690 |
no MR -> candidate analysis |
| CCL18/TFPI protein level ratio |
4e-986 |
rs56683451 |
1 |
GCST90313691 |
no MR -> candidate analysis |
| C-C motif chemokine 18 levels |
2e-635 |
rs2015086 |
10 |
GCST90246906 |
no MR -> candidate analysis |
| Circulating CCL23 levels (id: OID00530_OID20693) |
3e-360 |
rs712046 |
1 |
GCST90859884 |
no MR -> candidate analysis |
| C-C motif chemokine 3 levels |
2e-314 |
rs2015086 |
5 |
GCST90246917 |
no MR -> candidate analysis |
| CCL16 protein levels |
1e-299 |
rs117259529 |
1 |
GCST90468568 |
no MR -> candidate analysis |
| Circulating CCL14 levels |
4e-296 |
rs854466 |
2 |
GCST90860489 |
no MR -> candidate analysis |
| Circulating CCL23 levels (id: OID00811_OID20693) |
8e-263 |
rs712046 |
1 |
GCST90860141 |
no MR -> candidate analysis |
| CCL15 protein levels |
3e-260 |
rs117759380 |
5 |
GCST90468567 |
no MR -> candidate analysis |
| Serum levels of protein CCL18 |
4e-237 |
rs854469 |
2 |
GCST90088203 |
no MR -> candidate analysis |
| …and 31 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
No genetically-associated diseases retrieved from Open Targets.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=0.0041, LOEUF=1.64 — LoF-tolerant |
| GWAS Catalog |
167 unique SNPs / 409 rows |
| ClinVar |
27 records; 11 pathogenic in sample of 27 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 520 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CCL18’.clinvar — Pathogenic count is over the 27 record(s) retrieved, NOT over all 27 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 43 traits by best p-value, aggregated from 89 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P55774 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000275385/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CCL18 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CCL18 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CCL18%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CCL18 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:32:48 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: pharmgkb