Protein Dossier — CCL22 (C-C motif chemokine 22)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: high cholesterol |
0.222 |
0.0209 |
2.20e-26 |
Wald ratio |
1 |
trans |
1 |
| Non-cancer illness code self-reported: deep venous thrombosis (dvt) |
0.294 |
0.0512 |
9.81e-09 |
Wald ratio |
1 |
trans |
NA |
| Non-cancer illness code self-reported: pulmonary embolism (with or without) dvt |
0.331 |
0.0775 |
1.97e-05 |
Wald ratio |
1 |
trans |
NA |
| Forced expiratory volume in 1-second (FEV1) |
0.0312 |
0.00837 |
1.96e-04 |
Wald ratio |
1 |
trans |
NA |
| Forced vital capacity (FVC) |
0.0285 |
0.00793 |
3.20e-04 |
Wald ratio |
1 |
trans |
NA |
| Eye problems or disorders: Glaucoma |
0.229 |
0.0654 |
4.57e-04 |
Wald ratio |
1 |
trans |
NA |
| Diagnoses - main ICD10: M16 Coxarthrosis [arthrosis of hip] |
0.222 |
0.0648 |
6.19e-04 |
Wald ratio |
1 |
trans |
NA |
| Non-cancer illness code self-reported: gout |
-0.404 |
0.124 |
0.00108 |
Wald ratio |
1 |
trans |
NA |
| Non-cancer illness code self-reported: hypothyroidism or myxoedema |
0.12 |
0.0381 |
0.00161 |
Wald ratio |
1 |
trans |
NA |
| Schizophrenia |
-0.148 |
0.048 |
0.00209 |
Wald ratio |
1 |
trans |
NA |
| Systolic blood pressure automated reading |
-0.0283 |
0.00991 |
0.00425 |
Wald ratio |
1 |
trans |
NA |
| Alcohol intake frequency |
-0.04 |
0.0143 |
0.00512 |
Wald ratio |
1 |
trans |
NA |
| …and 63 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3508_78_3 |
MDC |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
30 association rows across 22 traits (24 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| CCL17/PDGFB protein level ratio |
9e-164 |
rs9925562 |
1 |
GCST90313688 |
no MR -> candidate analysis |
| CCL13/CCL17 protein level ratio |
2e-155 |
rs9925562 |
1 |
GCST90313674 |
no MR -> candidate analysis |
| CCL17/THPO protein level ratio |
1e-149 |
rs9925562 |
1 |
GCST90313689 |
no MR -> candidate analysis |
| CCL17/F2R protein level ratio |
1e-141 |
rs9925562 |
1 |
GCST90313686 |
no MR -> candidate analysis |
| CCL22 protein levels |
4e-139 |
rs41398344 |
4 |
GCST90468574 |
no MR -> candidate analysis |
| CX3CL1/RGMB protein level ratio |
1e-72 |
rs35053878 |
1 |
GCST90314327 |
no MR -> candidate analysis |
| C-C motif chemokine 22 levels (CCL22.3508.78.3) |
4e-32 |
rs41398344 |
1 |
GCST90240490 |
no MR -> candidate analysis |
| C-C motif chemokine 22 levels |
3e-31 |
rs72784876 |
4 |
GCST90246911 |
no MR -> candidate analysis |
| Serum levels of protein CCL22 |
1e-22 |
rs223883 |
1 |
GCST90088427 |
no MR -> candidate analysis |
| Systemic lupus erythematosus |
3e-15 |
rs669763 |
3 |
GCST011956 |
no MR -> candidate analysis |
| High density lipoprotein cholesterol levels |
3e-15 |
rs4359426 |
1 |
GCST90019510 |
no MR -> candidate analysis |
| C-C motif chemokine 17 levels |
8e-15 |
rs9921681 |
1 |
GCST90161830 |
no MR -> candidate analysis |
| …and 10 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 547 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| systemic lupus erythematosus |
0.65 |
— |
common-variant locus |
no MR -> candidate analysis |
| pathological myopia |
0.116 |
— |
common-variant locus |
no MR -> candidate analysis |
| Microscopic hematuria |
0.102 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 3 rows above, 3 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (C-C motif chemokine 22) |
| gnomAD constraint |
pLI=0.0033, LOEUF=1.72 — LoF-tolerant |
| GWAS Catalog |
77 unique SNPs / 154 rows |
| ClinVar |
48 records; 11 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 547 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘CCL22’ and resolved to ‘C-C motif chemokine 22’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 48 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 22 traits by best p-value, aggregated from 30 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/O00626 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000102962/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4295649/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/CCL22 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CCL22 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CCL22%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CCL22 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:35:12 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: pharmgkb