Protein Dossier — CCL23 (C-C motif chemokine 23)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: bladder problem (not cancer) |
0.168 |
0.0545 |
0.00208 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: C61 Malignant neoplasm of prostate |
0.136 |
0.0526 |
0.00978 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter |
0.129 |
0.0514 |
0.0121 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: gastro-oesophageal reflux (gord) or gastric reflux |
-0.0588 |
0.025 |
0.0189 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: vitiligo |
0.458 |
0.196 |
0.0198 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypertension |
0.0186 |
0.0082 |
0.0232 |
Wald ratio |
1 |
cis |
NA |
| Forced vital capacity (FVC) |
-0.00904 |
0.00402 |
0.0246 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: bone disorder |
0.19 |
0.0871 |
0.0288 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I30 Acute pericarditis |
0.415 |
0.193 |
0.0317 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: L03 Cellulitis |
0.102 |
0.0494 |
0.0389 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I48 Atrial fibrillation and flutter |
0.0864 |
0.0426 |
0.0426 |
Wald ratio |
1 |
cis |
NA |
| Intracranial volume |
7.81e+03 |
3.88e+03 |
0.0444 |
Wald ratio |
1 |
cis |
NA |
| …and 79 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2913_1_2 |
MPIF-1 |
Suhre K |
2019 |
prot-c-3028_36_2 |
Ck-b-8-1 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
145 association rows across 61 traits (139 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating CCL18 levels |
9e-1471 |
rs2015086 |
2 |
GCST90860473 |
no MR -> candidate analysis |
| C-C motif chemokine 15 levels |
3e-1432 |
rs854628 |
6 |
GCST90246903 |
no MR -> candidate analysis |
| ANG/CCL18 protein level ratio |
7e-1018 |
rs56683451 |
1 |
GCST90313258 |
no MR -> candidate analysis |
| CCL18/RARRES2 protein level ratio |
2e-1001 |
rs56683451 |
1 |
GCST90313690 |
no MR -> candidate analysis |
| CCL18/TFPI protein level ratio |
4e-986 |
rs56683451 |
1 |
GCST90313691 |
no MR -> candidate analysis |
| C-C motif chemokine 14 levels |
2e-763 |
rs7222922 |
7 |
GCST90246902 |
no MR -> candidate analysis |
| C-C motif chemokine 18 levels |
2e-635 |
rs2015086 |
9 |
GCST90246906 |
no MR -> candidate analysis |
| Circulating CCL23 levels (id: OID00530_OID20693) |
3e-360 |
rs712046 |
2 |
GCST90859884 |
no MR -> candidate analysis |
| C-C motif chemokine 3 levels |
2e-314 |
rs2015086 |
5 |
GCST90246917 |
no MR -> candidate analysis |
| CCL16 protein levels |
1e-299 |
rs117259529 |
1 |
GCST90468568 |
no MR -> candidate analysis |
| Circulating CCL14 levels |
4e-296 |
rs854466 |
2 |
GCST90860489 |
no MR -> candidate analysis |
| Serum levels of protein CCL15 |
3e-293 |
rs41508645 |
1 |
GCST90088428 |
no MR -> candidate analysis |
| …and 49 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 287 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| septic shock |
0.255 |
— |
common-variant locus |
no MR -> candidate analysis |
| immune system disorder |
0.255 |
— |
common-variant locus |
no MR -> candidate analysis |
| pernicious anemia |
0.082 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 3 rows above, 3 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=0.00071, LOEUF=1.43 — LoF-tolerant |
| GWAS Catalog |
171 unique SNPs / 418 rows |
| ClinVar |
43 records; 4 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 287 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CCL23’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 43 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 61 traits by best p-value, aggregated from 145 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P55773 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000274736/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CCL23 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CCL23 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CCL23%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CCL23 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:36:00 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: pharmgkb