Protein Dossier — CCL25 (C-C motif chemokine 25)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Height |
-0.0828 |
0.0155 |
9.64e-08 |
Wald ratio |
1 |
trans |
0.00633 |
| Caudate volume |
-34 |
9.89 |
5.90e-04 |
Inverse variance weighted |
2 |
trans |
NA |
| Caudate volume |
-34 |
9.89 |
5.90e-04 |
Inverse variance weighted |
2 |
cis |
NA |
| Total cholesterol |
-0.0663 |
0.0197 |
7.56e-04 |
Wald ratio |
1 |
trans |
NA |
| Non-cancer illness code self-reported: hyperthyroidism or thyrotoxicosis |
0.00117 |
0.000372 |
0.00173 |
Inverse variance weighted |
2 |
trans |
NA |
| Non-cancer illness code self-reported: hyperthyroidism or thyrotoxicosis |
0.00117 |
0.000372 |
0.00173 |
Inverse variance weighted |
2 |
cis |
NA |
| Ischemic stroke |
-0.216 |
0.0844 |
0.0103 |
Wald ratio |
1 |
trans |
NA |
| Pancreatic cancer |
-0.604 |
0.254 |
0.0175 |
Wald ratio |
1 |
trans |
NA |
| Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level |
0.0002 |
9.2e-05 |
0.03 |
Inverse variance weighted |
2 |
trans |
NA |
| Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level |
0.0002 |
9.2e-05 |
0.03 |
Inverse variance weighted |
2 |
cis |
NA |
| Non-cancer illness code self-reported: iron deficiency anaemia |
-0.000682 |
0.000317 |
0.0312 |
Inverse variance weighted |
2 |
trans |
NA |
| Non-cancer illness code self-reported: iron deficiency anaemia |
-0.000682 |
0.000317 |
0.0312 |
Inverse variance weighted |
2 |
cis |
NA |
| …and 162 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2705_5_2 |
TECK |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
37 association rows across 13 traits (35 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating CCL25 levels |
5e-3726 |
rs2032887 |
5 |
GCST90859901 |
no MR -> candidate analysis |
| C-C motif chemokine 25 levels |
4e-830 |
rs2032887 |
9 |
GCST90274768 |
no MR -> candidate analysis |
| Blood protein levels |
1e-160 |
rs77625270 |
2 |
GCST006585 |
no MR -> candidate analysis |
| C-C motif chemokine 25 levels (CCL25.2705.5.2) |
5e-114 |
rs74959615 |
4 |
GCST90240493 |
no MR -> candidate analysis |
| CCL25 protein levels |
2e-89 |
rs112560582 |
6 |
GCST90468577 |
no MR -> candidate analysis |
| Serum levels of protein CCL25 |
5e-80 |
rs7259568 |
3 |
GCST90088027 |
no MR -> candidate analysis |
| TECK plasma levels |
2e-45 |
rs2032887 |
1 |
GCST90085778 |
no MR -> candidate analysis |
| CCL25 levels |
1e-37 |
rs2032887 |
2 |
GCST90000446 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein CCL25 levels |
7e-22 |
rs2032887 |
1 |
GCST90943136 |
no MR -> candidate analysis |
| Protein levels in obesity |
1e-15 |
rs11671930 |
1 |
GCST010196 |
no MR -> candidate analysis |
| Rickets or osteomalacia (PheCode 261.41) |
2e-11 |
rs184027577 |
1 |
GCST90479911 |
no MR -> candidate analysis |
| Alzheimer’s disease or family history of Alzheimer’s disease |
4e-8 |
rs573469061 |
1 |
GCST90624094 |
no MR -> candidate analysis |
| …and 1 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 293 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| vision disorder |
0.057 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 1 rows above, 1 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=0.00033, LOEUF=1.1 — LoF-tolerant |
| GWAS Catalog |
71 unique SNPs / 141 rows |
| ClinVar |
26 records; 6 pathogenic in sample of 26 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 293 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CCL25’.clinvar — Pathogenic count is over the 26 record(s) retrieved, NOT over all 26 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 13 of 13 traits by best p-value, aggregated from 37 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/O15444 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000131142/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CCL25 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CCL25 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CCL25%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CCL25 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:36:48 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: pharmgkb