Protein Dossier — CCL27 (C-C motif chemokine 27)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Serum creatinine (eGFRcrea) |
-0.0131 |
0.00467 |
0.00511 |
Wald ratio |
1 |
cis |
NA |
| Cough on most days |
0.155 |
0.0561 |
0.00567 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R10 Abdominal and pelvic pain |
0.146 |
0.0534 |
0.00638 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: sleep apnoea |
0.415 |
0.157 |
0.00809 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypertension |
0.0508 |
0.0207 |
0.014 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: enlarged prostate |
0.216 |
0.0887 |
0.0148 |
Wald ratio |
1 |
cis |
NA |
| Body fat |
-0.0692 |
0.0287 |
0.0158 |
Wald ratio |
1 |
cis |
NA |
| Alcohol intake frequency |
-0.0453 |
0.0189 |
0.0164 |
Wald ratio |
1 |
cis |
NA |
| Birth weight |
0.0467 |
0.0199 |
0.0191 |
Wald ratio |
1 |
cis |
NA |
| Depressive symptoms |
-0.0436 |
0.0187 |
0.0196 |
Wald ratio |
1 |
cis |
NA |
| Systemic lupus erythematosus |
-0.599 |
0.26 |
0.021 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypothyroidism or myxoedema |
0.115 |
0.0507 |
0.0233 |
Wald ratio |
1 |
cis |
NA |
| …and 97 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2192_63_10 |
CTACK |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
11 association rows across 9 traits (9 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating CCL27 levels |
2e-98 |
rs2812349 |
1 |
GCST90860726 |
no MR -> candidate analysis |
| C-C motif chemokine 27 levels |
6e-20 |
rs867811 |
2 |
GCST90137615 |
no MR -> candidate analysis |
| Serum levels of protein PAPLN |
7e-13 |
rs72737145 |
1 |
GCST90086640 |
no MR -> candidate analysis |
| Interleukin-11 receptor subunit alpha (analyte X3814.63) lev |
3e-11 |
rs78600552 |
1 |
GCST90425887 |
no MR -> candidate analysis |
| Noncognitive aspects of educational attainment |
2e-9 |
rs6476459 |
1 |
GCST90011874 |
no MR -> candidate analysis |
| Core binding factor acute myeloid leukemia |
7e-9 |
rs3176820; rs2772559; rs3176818; rs3176817; rs3176813 |
2 |
GCST008413 |
no MR -> candidate analysis |
| Height at take-off |
1e-8 |
rs2026118 |
1 |
GCST90567945 |
no MR -> candidate analysis |
| Baseline memory in normal cognition |
6e-6 |
rs913835 |
1 |
GCST90448423 |
no MR -> candidate analysis |
| Height |
7e-6 |
rs2026118 |
1 |
GCST90567944 |
MR: beta=0.0202, p=0.194 (cis) |
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
No genetically-associated diseases retrieved from Open Targets.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=0.00091, LOEUF=1.88 — LoF-tolerant |
| GWAS Catalog |
59 unique SNPs / 118 rows |
| ClinVar |
98 records; 10 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 498 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CCL27’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 98 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 9 of 9 traits by best p-value, aggregated from 11 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9Y4X3 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000213927/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CCL27 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CCL27 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CCL27%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CCL27 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:37:02 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none