Protein Dossier — CCL28 (C-C motif chemokine 28)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Diagnoses - main ICD10: K43 Ventral hernia |
0.31 |
0.0848 |
2.56e-04 |
Inverse variance weighted |
2 |
trans |
NA |
| Diagnoses - main ICD10: K43 Ventral hernia |
0.31 |
0.0848 |
2.56e-04 |
Inverse variance weighted |
2 |
trans |
NA |
| Height |
0.034 |
0.0121 |
0.00511 |
Wald ratio |
1 |
trans |
NA |
| Systemic lupus erythematosus |
0.49 |
0.188 |
0.00927 |
Wald ratio |
1 |
trans |
NA |
| PGC cross-disorder traits |
-0.0983 |
0.0389 |
0.0116 |
Inverse variance weighted |
2 |
trans |
NA |
| PGC cross-disorder traits |
-0.0983 |
0.0389 |
0.0116 |
Inverse variance weighted |
2 |
trans |
NA |
| Iron |
0.0992 |
0.0413 |
0.0163 |
Wald ratio |
1 |
trans |
NA |
| Amygdala volume |
-17.8 |
7.44 |
0.0171 |
Inverse variance weighted |
2 |
trans |
NA |
| Amygdala volume |
-17.8 |
7.44 |
0.0171 |
Inverse variance weighted |
2 |
trans |
NA |
| Schizophrenia |
-0.0795 |
0.0339 |
0.0189 |
Inverse variance weighted |
2 |
trans |
NA |
| Schizophrenia |
-0.0795 |
0.0339 |
0.0189 |
Inverse variance weighted |
2 |
trans |
NA |
| Non-cancer illness code self-reported: asthma |
0.0472 |
0.0204 |
0.0209 |
Inverse variance weighted |
2 |
trans |
NA |
| …and 159 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2890_59_2 |
CCL28 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
30 association rows across 22 traits (21 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating CCL28 levels |
7e-27 |
rs4866742 |
1 |
GCST90859892 |
no MR -> candidate analysis |
| GHR protein levels |
3e-21 |
rs77860766 |
2 |
GCST90469342 |
no MR -> candidate analysis |
| C7 protein levels |
5e-18 |
rs141365528 |
1 |
GCST90468502 |
no MR -> candidate analysis |
| CCL28 protein levels |
2e-17 |
rs371029709 |
1 |
GCST90468580 |
no MR -> candidate analysis |
| High light scatter reticulocyte percentage (UKB data field 3 |
4e-17 |
rs750583 |
1 |
GCST90468077 |
no MR -> candidate analysis |
| Red cell distribution width |
2e-16 |
rs750583 |
2 |
GCST90002369 |
no MR -> candidate analysis |
| Red blood cell erythrocyte distribution width (UKB data fiel |
3e-16 |
rs750583 |
1 |
GCST90468099 |
no MR -> candidate analysis |
| High light scatter reticulocyte percentage of red cells |
9e-14 |
rs372212227 |
1 |
GCST90002386 |
no MR -> candidate analysis |
| High light scatter reticulocyte count |
1e-13 |
rs372212227 |
1 |
GCST90002385 |
no MR -> candidate analysis |
| Immature fraction of reticulocytes |
8e-13 |
rs372212227 |
1 |
GCST90002387 |
no MR -> candidate analysis |
| Self-reported math ability (MTAG) |
1e-12 |
rs56206275 |
1 |
GCST006569 |
no MR -> candidate analysis |
| Self-reported math ability |
9e-11 |
rs56206275 |
1 |
GCST006573 |
no MR -> candidate analysis |
| …and 10 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 515 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| mathematical ability |
0.172 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 1 rows above, 1 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=0.11, LOEUF=1.29 — LoF-tolerant |
| GWAS Catalog |
46 unique SNPs / 89 rows |
| ClinVar |
47 records; 7 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 515 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CCL28’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 47 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 22 traits by best p-value, aggregated from 30 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9NRJ3 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000151882/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CCL28 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CCL28 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CCL28%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CCL28 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:37:15 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none