Protein Dossier — CCL3 (C-C motif chemokine 3)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Neo-openness to experience |
-0.413 |
0.149 |
0.00567 |
Wald ratio |
1 |
cis |
NA |
| Eye problems or disorders: Injury or trauma resulting in loss of vision |
-0.228 |
0.0826 |
0.00583 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: G47 Sleep disorders |
-0.197 |
0.0801 |
0.0141 |
Wald ratio |
1 |
cis |
NA |
| HDL cholesterol |
0.0231 |
0.0104 |
0.0258 |
Wald ratio |
1 |
cis |
NA |
| Amyotrophic lateral sclerosis |
0.0795 |
0.0368 |
0.0308 |
Wald ratio |
1 |
cis |
NA |
| Pallidum volume |
-8.4 |
3.94 |
0.0331 |
Wald ratio |
1 |
cis |
NA |
| Underlying (primary) cause of death: ICD10: E85.4 Organ-limited amyloidosis |
1.08 |
0.505 |
0.0332 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: J33 Nasal polyp |
-0.188 |
0.0885 |
0.0341 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I84 Haemorrhoids |
0.0621 |
0.0303 |
0.0403 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: L03 Cellulitis |
-0.131 |
0.0638 |
0.0404 |
Wald ratio |
1 |
cis |
NA |
| Alzheimer’s disease |
0.0689 |
0.0337 |
0.0412 |
Wald ratio |
1 |
cis |
NA |
| Eczema |
0.0722 |
0.0363 |
0.0466 |
Wald ratio |
1 |
cis |
NA |
| …and 78 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3040_59_1 |
MIP-1a |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
30 association rows across 23 traits (28 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating CCL3 levels (id: OID00532_OID20610) |
1e-972 |
rs1719126 |
2 |
GCST90859886 |
no MR -> candidate analysis |
| Circulating CCL3 levels (id: OID00440_OID20610) |
3e-934 |
rs1719126 |
2 |
GCST90859800 |
no MR -> candidate analysis |
| Circulating CCL3 levels (id: OID00813_OID20610) |
1e-679 |
rs1719126 |
2 |
GCST90860143 |
no MR -> candidate analysis |
| Macrophage inflammatory protein 1a levels |
1e-202 |
rs8951 |
1 |
GCST90274825 |
no MR -> candidate analysis |
| CCL16 protein levels |
2e-200 |
rs148048971 |
2 |
GCST90468568 |
no MR -> candidate analysis |
| Circulating CCL4 levels (id: OID00796_OID20695) |
2e-156 |
rs200657610 |
1 |
GCST90860128 |
no MR -> candidate analysis |
| CCL4 protein levels |
2e-149 |
rs1634513 |
1 |
GCST90468583 |
no MR -> candidate analysis |
| Circulating CCL4 levels (id: OID00498_OID20695) |
3e-140 |
rs200657610 |
1 |
GCST90859854 |
no MR -> candidate analysis |
| C-C motif chemokine 3-like 1 levels |
6e-69 |
rs149759822 |
1 |
GCST90137673 |
no MR -> candidate analysis |
| CCL14 protein levels |
5e-50 |
rs8073437 |
1 |
GCST90468566 |
no MR -> candidate analysis |
| CCL18 protein levels |
4e-48 |
rs1879917 |
2 |
GCST90468570 |
no MR -> candidate analysis |
| CCL3 protein levels |
2e-45 |
rs764872 |
3 |
GCST90428428 |
no MR -> candidate analysis |
| …and 11 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
No genetically-associated diseases retrieved from Open Targets.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=0.015, LOEUF=1.46 — LoF-tolerant |
| GWAS Catalog |
137 unique SNPs / 335 rows |
| ClinVar |
34 records; 7 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 1124 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CCL3’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 34 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 23 traits by best p-value, aggregated from 30 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P10147 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000277632/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CCL3 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CCL3 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CCL3%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CCL3 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:37:32 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none