Protein Dossier — CCL5 (C-C motif chemokine 5)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Neo-agreeableness |
-0.811 |
0.237 |
6.11e-04 |
Wald ratio |
1 |
cis |
NA |
| Body mass index (BMI) |
0.0309 |
0.00902 |
6.16e-04 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypertrophic cardiomyopathy (hcm or hocm) |
0.91 |
0.278 |
0.00107 |
Wald ratio |
1 |
cis |
NA |
| Birth weight |
0.0364 |
0.0133 |
0.00616 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Wrist |
0.143 |
0.056 |
0.0106 |
Wald ratio |
1 |
cis |
NA |
| Percent emphysema |
0.0749 |
0.0309 |
0.0155 |
Wald ratio |
1 |
cis |
NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) |
-0.0535 |
0.0231 |
0.0208 |
Wald ratio |
1 |
cis |
NA |
| Autism |
0.243 |
0.105 |
0.021 |
Wald ratio |
1 |
cis |
NA |
| Vascular or heart problems diagnosed by doctor: Angina |
0.104 |
0.0457 |
0.0225 |
Wald ratio |
1 |
cis |
NA |
| Birth length |
0.0798 |
0.0379 |
0.0351 |
Wald ratio |
1 |
cis |
NA |
| Sleep duration |
-0.0145 |
0.00704 |
0.0394 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: arthritis (nos) |
0.18 |
0.0875 |
0.0395 |
Wald ratio |
1 |
cis |
NA |
| …and 102 more outcomes (see JSON) |
|
|
|
|
|
|
|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2523_31_3 |
RANTES |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
11 association rows across 10 traits (11 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating CCL5 levels |
6e-179 |
rs2107538 |
1 |
GCST90860445 |
no MR -> candidate analysis |
| CCL5 protein levels |
2e-169 |
rs2107538 |
1 |
GCST90468584 |
no MR -> candidate analysis |
| Dynorphin A (1-17) levels |
7e-107 |
rs2107538 |
1 |
GCST90247380 |
no MR -> candidate analysis |
| Delta-like protein 3 levels |
2e-73 |
rs3817655 |
1 |
GCST90247295 |
no MR -> candidate analysis |
| C-C motif chemokine 5 levels |
2e-67 |
rs7211393 |
2 |
GCST90246920 |
no MR -> candidate analysis |
| Blood protein levels |
5e-35 |
rs2107538 |
1 |
GCST006585 |
no MR -> candidate analysis |
| Reticulocyte percentage (UKB data field 30240) |
1e-14 |
rs41471045 |
1 |
GCST90468101 |
no MR -> candidate analysis |
| Reticulocyte count (UKB data field 30250) |
1e-14 |
rs41471045 |
1 |
GCST90468100 |
no MR -> candidate analysis |
| CCL16 protein levels |
2e-12 |
rs28914803 |
1 |
GCST90468568 |
no MR -> candidate analysis |
| C-C motif chemokine 5 (analyte X5480.49) levels |
2e-10 |
rs1800825 |
1 |
GCST90426363 |
no MR -> candidate analysis |
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 1352 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| poisoning |
0.261 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 1 rows above, 1 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (C-C motif chemokine 5) |
| gnomAD constraint |
pLI=0.085, LOEUF=1.16 — LoF-tolerant |
| GWAS Catalog |
84 unique SNPs / 165 rows |
| ClinVar |
28 records; 7 pathogenic in sample of 28 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 1352 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘CCL5’ and resolved to ‘C-C motif chemokine 5’ — confirm this is the intended target.clinvar — Pathogenic count is over the 28 record(s) retrieved, NOT over all 28 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 10 of 10 traits by best p-value, aggregated from 11 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P13501 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000271503/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL1275217/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/CCL5 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CCL5 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CCL5%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CCL5 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:38:34 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none