Protein Dossier — CCL7 (C-C motif chemokine 7)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Crohn’s disease |
0.0511 |
0.0168 |
0.00239 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: kidney stone or ureter stone or bladder stone |
0.0966 |
0.0341 |
0.00466 |
Wald ratio |
1 |
cis |
NA |
| Inflammatory bowel disease |
0.0374 |
0.0138 |
0.00689 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: mania or bipolar disorder or manic depression |
0.133 |
0.0572 |
0.0198 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] |
-0.0577 |
0.0254 |
0.0229 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter |
0.081 |
0.0365 |
0.0266 |
Wald ratio |
1 |
cis |
NA |
| Percent emphysema |
0.0293 |
0.0135 |
0.03 |
Wald ratio |
1 |
cis |
NA |
| Microalbuminuria |
-0.057 |
0.027 |
0.0348 |
Wald ratio |
1 |
cis |
NA |
| Subjective well being |
0.008 |
0.004 |
0.0455 |
Wald ratio |
1 |
cis |
NA |
| Fracture resulting from simple fall |
-0.0176 |
0.00894 |
0.0484 |
Wald ratio |
1 |
cis |
NA |
| Mean platelet volume |
-0.0027 |
0.0014 |
0.0538 |
Wald ratio |
1 |
cis |
NA |
| Systemic lupus erythematosus |
-0.122 |
0.0642 |
0.0575 |
Wald ratio |
1 |
cis |
NA |
| …and 99 more outcomes (see JSON) |
|
|
|
|
|
|
|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4886_3_1 |
MCP-3 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
29 association rows across 14 traits (26 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating CCL7 levels (id: OID00474_OID20523) |
2e-42 |
rs3091323 |
3 |
GCST90859834 |
no MR -> candidate analysis |
| Circulating CCL11 levels (id: OID00505_OID20668) |
1e-34 |
rs1860185 |
2 |
GCST90859861 |
no MR -> candidate analysis |
| Circulating CCL7 levels (id: OID00755_OID20523) |
4e-32 |
rs3091323 |
3 |
GCST90860091 |
no MR -> candidate analysis |
| Circulating CCL11 levels (id: OID00970_OID20668) |
2e-28 |
rs1860185 |
2 |
GCST90860201 |
no MR -> candidate analysis |
| Inflammatory bowel disease |
1e-26 |
rs3091316 |
4 |
GCST001725 |
MR: beta=0.0374, p=0.00689 (cis) |
| Crohn’s disease |
8e-25 |
rs3091315 |
5 |
GCST003044 |
MR: beta=0.0511, p=0.00239 (cis) |
| CCL8 protein levels |
4e-24 |
rs62054929 |
2 |
GCST90468586 |
no MR -> candidate analysis |
| Serum levels of protein CDSN |
3e-21 |
rs2530797 |
1 |
GCST90089652 |
no MR -> candidate analysis |
| C-C motif chemokine 2 levels |
2e-13 |
rs112062237 |
1 |
GCST90425339 |
no MR -> candidate analysis |
| C-C motif chemokine 7 levels |
5e-13 |
rs2190970 |
1 |
GCST90162169 |
no MR -> candidate analysis |
| Inflammatory bowel disease (MTAG) |
3e-10 |
rs3091316 |
1 |
GCST90503485 |
no MR -> candidate analysis |
| CCL2 protein levels |
4e-8 |
rs2887259 |
1 |
GCST90428424 |
no MR -> candidate analysis |
| …and 2 more traits (see JSON) |
|
|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 598 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Crohn disease |
0.447 |
— |
common-variant locus |
no MR -> candidate analysis |
| trauma complication |
0.375 |
— |
common-variant locus |
no MR -> candidate analysis |
| inflammatory bowel disease |
0.343 |
— |
common-variant locus |
MR: beta=0.0374, p=0.00689 (cis) |
| ulcerative colitis |
0.234 |
— |
common-variant locus |
MR: beta=0.026, p=0.134 (cis) |
| alcohol drinking |
0.182 |
— |
common-variant locus |
no MR -> candidate analysis |
| cartilage disease |
0.185 |
— |
common-variant locus |
no MR -> candidate analysis |
| Abnormality of the skeletal system |
0.174 |
— |
common-variant locus |
no MR -> candidate analysis |
| acute tonsillitis |
0.174 |
— |
common-variant locus |
no MR -> candidate analysis |
| Hodgkins lymphoma |
0.167 |
— |
common-variant locus |
no MR -> candidate analysis |
| colitis |
0.152 |
— |
common-variant locus |
MR: beta=0.026, p=0.134 (cis) |
| enteritis |
0.152 |
— |
common-variant locus |
no MR -> candidate analysis |
| lagophthalmos |
0.124 |
— |
common-variant locus |
no MR -> candidate analysis |
| exostosis |
0.123 |
— |
common-variant locus |
no MR -> candidate analysis |
| sinusitis |
0.122 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 14 rows above, 11 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (C-C motif chemokine 7) |
| gnomAD constraint |
pLI=0.00062, LOEUF=2.04 — LoF-tolerant |
| GWAS Catalog |
100 unique SNPs / 206 rows |
| ClinVar |
27 records; 5 pathogenic in sample of 27 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 598 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘CCL7’ and resolved to ‘C-C motif chemokine 7’ — confirm this is the intended target.clinvar — Pathogenic count is over the 27 record(s) retrieved, NOT over all 27 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 14 of 14 traits by best p-value, aggregated from 29 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P80098 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000108688/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3217391/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/CCL7 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CCL7 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CCL7%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CCL7 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:39:20 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none