Protein Dossier — CCL8 (C-C motif chemokine 8)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Crohn’s disease |
0.109 |
0.0358 |
0.00239 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: kidney stone or ureter stone or bladder stone |
0.195 |
0.066 |
0.00311 |
Wald ratio |
1 |
cis |
NA |
| Inflammatory bowel disease |
0.0795 |
0.0294 |
0.00689 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: mania or bipolar disorder or manic depression |
0.265 |
0.108 |
0.014 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter |
0.165 |
0.0717 |
0.0215 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] |
-0.127 |
0.058 |
0.0286 |
Wald ratio |
1 |
cis |
NA |
| Percent emphysema |
0.0623 |
0.0287 |
0.03 |
Wald ratio |
1 |
cis |
NA |
| Microalbuminuria |
-0.121 |
0.0574 |
0.0348 |
Wald ratio |
1 |
cis |
NA |
| Subjective well being |
0.017 |
0.0085 |
0.0455 |
Wald ratio |
1 |
cis |
NA |
| Fracture resulting from simple fall |
-0.0379 |
0.0194 |
0.0508 |
Wald ratio |
1 |
cis |
NA |
| Mean platelet volume |
-0.00574 |
0.00298 |
0.0538 |
Wald ratio |
1 |
cis |
NA |
| Systemic lupus erythematosus |
-0.259 |
0.136 |
0.0575 |
Wald ratio |
1 |
cis |
NA |
| …and 97 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2785_15_2 |
MCP-2 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
88 association rows across 40 traits (76 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating CCL8 levels (id: OID00549_OID21466) |
1e-5501 |
rs1133763 |
4 |
GCST90859899 |
no MR -> candidate analysis |
| Circulating CCL8 levels (id: OID00795_OID21466) |
4e-3481 |
rs1133763 |
4 |
GCST90860127 |
no MR -> candidate analysis |
| C-C motif chemokine 8 levels |
8e-1704 |
rs1133763 |
8 |
GCST90246922 |
no MR -> candidate analysis |
| C-C motif chemokine 7 levels |
2e-718 |
rs1133763 |
10 |
GCST90246921 |
no MR -> candidate analysis |
| CCL13/CCL8 protein level ratio |
9e-495 |
rs11652256 |
1 |
GCST90313676 |
no MR -> candidate analysis |
| Blood protein levels |
2e-460 |
rs4795912 |
6 |
GCST006585 |
no MR -> candidate analysis |
| CCL13 protein levels |
4e-263 |
rs3136674 |
2 |
GCST90468565 |
no MR -> candidate analysis |
| C-C motif chemokine 8 (analyte X13748.4) levels |
1e-187 |
rs12450497 |
1 |
GCST90422346 |
no MR -> candidate analysis |
| Corneodesmosin levels |
1e-120 |
rs3136674 |
1 |
GCST90247131 |
no MR -> candidate analysis |
| CCL8 protein levels |
2e-116 |
rs34202026 |
16 |
GCST90468586 |
no MR -> candidate analysis |
| Serum levels of protein CCL8 |
5e-109 |
rs3138036 |
1 |
GCST90088070 |
no MR -> candidate analysis |
| C-C motif chemokine 7 levels (CCL7.4886.3.1) |
7e-72 |
rs11342894 |
2 |
GCST90240501 |
no MR -> candidate analysis |
| …and 28 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 456 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| alcohol drinking |
0.198 |
— |
common-variant locus |
no MR -> candidate analysis |
| systemic lupus erythematosus |
0.04 |
— |
common-variant locus |
MR: beta=-0.259, p=0.0575 (cis) |
| inflammatory bowel disease |
0.135 |
— |
common-variant locus |
MR: beta=0.0795, p=0.00689 (cis) |
| cartilage disease |
0.095 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 4 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=0.24, LOEUF=1.17 — LoF-tolerant |
| GWAS Catalog |
87 unique SNPs / 174 rows |
| ClinVar |
38 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 456 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CCL8’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 38 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 40 traits by best p-value, aggregated from 88 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P80075 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000108700/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CCL8 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CCL8 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CCL8%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CCL8 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:39:35 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none