Protein Dossier — CD200R1 (Cell surface glycoprotein CD200 receptor 1)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: asthma |
0.15 |
0.0336 |
8.51e-06 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypopituitarism |
0.979 |
0.319 |
0.00215 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I80 Phlebitis and thrombophlebitis |
0.415 |
0.138 |
0.00255 |
Wald ratio |
1 |
cis |
NA |
| Eczema |
0.288 |
0.0972 |
0.00307 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: pernicious anaemia |
0.477 |
0.164 |
0.00369 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I48 Atrial fibrillation and flutter |
0.285 |
0.1 |
0.00444 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hayfever or allergic rhinitis |
0.133 |
0.0502 |
0.00834 |
Wald ratio |
1 |
cis |
NA |
| Cancer code self-reported: basal cell carcinoma |
0.286 |
0.111 |
0.00971 |
Wald ratio |
1 |
cis |
NA |
| Serum creatinine (eGFRcrea) |
0.0125 |
0.00523 |
0.0168 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: pneumothorax |
0.795 |
0.355 |
0.0253 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R07 Pain in throat and chest |
0.114 |
0.0555 |
0.04 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level |
0.743 |
0.366 |
0.0424 |
Wald ratio |
1 |
cis |
NA |
| …and 94 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5103_30_3 |
MO2R1 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
37 association rows across 22 traits (34 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating CD200R1 levels |
4e-3173 |
rs79556290 |
3 |
GCST90859738 |
no MR -> candidate analysis |
| CD200R1 protein levels |
1e-270 |
rs4682447 |
4 |
GCST90468605 |
no MR -> candidate analysis |
| Cell surface glycoprotein CD200 receptor 1 levels |
4e-174 |
rs77561169 |
3 |
GCST90059915 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein CD200R1 levels |
5e-59 |
rs57891445 |
1 |
GCST90943148 |
no MR -> candidate analysis |
| Neurological blood protein biomarker levels |
2e-30 |
rs79834152 |
2 |
GCST008478 |
no MR -> candidate analysis |
| Atopic dermatitis |
5e-29 |
rs6808249 |
2 |
GCST90244787 |
no MR -> candidate analysis |
| Eosinophil percentage of white cells |
9e-23 |
rs35297201 |
1 |
GCST90002382 |
no MR -> candidate analysis |
| Eosinophil count |
2e-22 |
rs12494693 |
4 |
GCST90002381 |
no MR -> candidate analysis |
| Height |
9e-21 |
rs7432373 |
1 |
GCST90245848 |
MR: beta=-0.0239, p=0.162 (cis) |
| CD200 protein levels |
2e-19 |
rs1488193 |
1 |
GCST90468606 |
no MR -> candidate analysis |
| Eosinophill count (UKB data field 30150) |
4e-19 |
rs12494693 |
1 |
GCST90468068 |
no MR -> candidate analysis |
| Circulating CD200 levels |
6e-18 |
rs55664715 |
1 |
GCST90859700 |
no MR -> candidate analysis |
| …and 10 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 294 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| asthma |
0.667 |
— |
common-variant locus |
MR: beta=0.15, p=8.51e-06 (cis) |
| atopic eczema |
0.668 |
— |
common-variant locus |
no MR -> candidate analysis |
| hypothyroidism |
0.669 |
— |
common-variant locus |
MR: beta=0.0725, p=0.209 (cis) |
| dermatitis |
0.667 |
— |
common-variant locus |
no MR -> candidate analysis |
| Eczematoid dermatitis |
0.55 |
— |
common-variant locus |
no MR -> candidate analysis |
| alcohol drinking |
0.466 |
— |
common-variant locus |
no MR -> candidate analysis |
| corneal neovascularization |
0.134 |
— |
common-variant locus |
no MR -> candidate analysis |
| device complication |
0.12 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 8 rows above, 6 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=8.7e-09, LOEUF=1.07 — LoF-tolerant |
| GWAS Catalog |
50 unique SNPs / 100 rows |
| ClinVar |
89 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 294 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CD200R1’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 89 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 22 traits by best p-value, aggregated from 37 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q8TD46 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000163606/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CD200R1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CD200R1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CD200R1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CD200R1 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:41:06 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none