MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Height | 0.0552 | 0.00713 | 9.79e-15 | Wald ratio | 1 | trans | 1.41e-06 |
| Non-cancer illness code self-reported: hypertension | 0.0332 | 0.00976 | 6.66e-04 | Wald ratio | 1 | trans | NA |
| Body mass index (BMI) | -0.0196 | 0.00592 | 9.21e-04 | Wald ratio | 1 | trans | NA |
| Potassium in urine | 0.0159 | 0.00601 | 0.00806 | Wald ratio | 1 | trans | NA |
| Fasting glucose | -0.0179 | 0.00759 | 0.0181 | Wald ratio | 1 | trans | NA |
| Eye problems or disorders: Glaucoma | 0.101 | 0.0448 | 0.0234 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: I84 Haemorrhoids | -0.0948 | 0.0419 | 0.0236 | Wald ratio | 1 | trans | NA |
| Neuroticism | -0.0207 | 0.0092 | 0.0244 | Wald ratio | 1 | trans | NA |
| Heel bone mineral density (BMD) T-score automated | 0.0169 | 0.00765 | 0.0274 | Wald ratio | 1 | trans | NA |
| PGC cross-disorder traits | 0.062 | 0.0285 | 0.0297 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: M23 Internal derangement of knee | -0.0925 | 0.0437 | 0.0345 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: osteoarthritis | -0.043 | 0.0207 | 0.0375 | Wald ratio | 1 | trans | NA |
| …and 98 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
20 association rows across 19 traits (17 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| CD34 protein levels | 1e-27 | rs6671850 | 1 | GCST90468626 | no MR -> candidate analysis |
| Refractive error | 1e-25 | rs2745953 | 2 | GCST90841196 | no MR -> candidate analysis |
| CR1 protein levels | 8e-21 | rs1932817 | 1 | GCST90468851 | no MR -> candidate analysis |
| Corneal resistance factor (MTAG) | 2e-19 | rs2745950 | 1 | GCST90102517 | no MR -> candidate analysis |
| CR2 protein levels | 1e-16 | rs2466570 | 1 | GCST90468852 | no MR -> candidate analysis |
| Central corneal thickness (MTAG) | 9e-15 | rs2745950 | 1 | GCST90102518 | no MR -> candidate analysis |
| Corneal resistance factor | 2e-11 | rs2745951 | 1 | GCST90308682 | no MR -> candidate analysis |
| Spherical equivalent | 3e-11 | rs2745953 | 1 | GCST010378 | no MR -> candidate analysis |
| Platelet count | 3e-11 | rs142735243 | 1 | GCST90662907 | no MR -> candidate analysis |
| Serum total protein levels | 1e-10 | rs2745949 | 1 | GCST90018976 | no MR -> candidate analysis |
| Gut microbial network clusters (Pink (at 1 year) x Household | 6e-10 | rs2267898 | 1 | GCST90569453 | no MR -> candidate analysis |
| General risk tolerance (MTAG) | 5e-9 | rs7572 | 1 | GCST007325 | no MR -> candidate analysis |
| …and 7 more traits (see JSON) |
Top diseases by Open Targets association (of 1787 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Abnormality of the skeletal system | 0.764 | — | common-variant locus | no MR -> candidate analysis |
| refractive error | 0.639 | — | common-variant locus | no MR -> candidate analysis |
| cardiac arrhythmia | 0.613 | — | common-variant locus | no MR -> candidate analysis |
| risk-taking behaviour | 0.612 | — | common-variant locus | no MR -> candidate analysis |
| injury | 0.509 | — | common-variant locus | no MR -> candidate analysis |
| ovarian neoplasm | 0.509 | — | common-variant locus | no MR -> candidate analysis |
| breast carcinoma | 0.413 | — | common-variant locus | no MR -> candidate analysis |
| familial hemolytic anemia | 0.431 | — | common-variant locus | no MR -> candidate analysis |
| skin cancer | 0.411 | — | common-variant locus | no MR -> candidate analysis |
| aging | 0.389 | — | common-variant locus | no MR -> candidate analysis |
| primary angle-closure glaucoma | 0.38 | — | common-variant locus | no MR -> candidate analysis |
| adolescent idiopathic scoliosis | 0.198 | — | common-variant locus | no MR -> candidate analysis |
| central serous retinopathy | 0.185 | — | common-variant locus | no MR -> candidate analysis |
| obesity disorder | 0.139 | — | common-variant locus | no MR -> candidate analysis |
Of the 14 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (CD34-positive blood stem/progenitor cell) |
| gnomAD constraint | pLI=1.5e-10, LOEUF=1.13 — LoF-tolerant |
| GWAS Catalog | 102 unique SNPs / 230 rows |
| ClinVar | 81 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 1787 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘CD34’ and resolved to ‘CD34-positive blood stem/progenitor cell’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 81 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 19 of 19 traits by best p-value, aggregated from 20 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P28906 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000174059/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4296384/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/CD34 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CD34 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CD34%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CD34 — GWAS Catalog search API (live; release not exposed)