Protein Dossier — CD55 (Complement decay-accelerating factor)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: retinal detachment |
0.246 |
0.0756 |
0.00112 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K57 Diverticular disease of intestine |
0.111 |
0.0348 |
0.00139 |
Wald ratio |
1 |
cis |
NA |
| Alzheimer’s disease |
-0.107 |
0.034 |
0.00172 |
Wald ratio |
1 |
cis |
NA |
| Systolic blood pressure automated reading |
-0.0169 |
0.00565 |
0.0027 |
Wald ratio |
1 |
cis |
NA |
| Heel bone mineral density (BMD) T-score automated |
0.021 |
0.00714 |
0.00326 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypothyroidism or myxoedema |
-0.0779 |
0.0265 |
0.00332 |
Wald ratio |
1 |
cis |
NA |
| Anorexia nervosa |
-0.208 |
0.0722 |
0.00392 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I84 Haemorrhoids |
0.0912 |
0.0324 |
0.00487 |
Wald ratio |
1 |
cis |
NA |
| Forced vital capacity (FVC) |
0.0118 |
0.00452 |
0.00935 |
Wald ratio |
1 |
cis |
NA |
| Systemic lupus erythematosus |
-0.255 |
0.101 |
0.012 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: diverticular disease or diverticulitis |
0.116 |
0.0465 |
0.0129 |
Wald ratio |
1 |
cis |
NA |
| Lung adenocarcinoma |
0.138 |
0.056 |
0.0136 |
Wald ratio |
1 |
cis |
NA |
| …and 102 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5069_9_3 |
DAF |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
53 association rows across 30 traits (35 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating CR2 levels |
3e-223 |
rs61821090 |
2 |
GCST90860456 |
no MR -> candidate analysis |
| CR2 protein levels |
5e-201 |
rs61821111 |
1 |
GCST90468852 |
no MR -> candidate analysis |
| Refractive error |
7e-68 |
rs6702997 |
2 |
GCST90841196 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein CD55 levels |
4e-49 |
rs116059019 |
1 |
GCST90944965 |
no MR -> candidate analysis |
| Complement decay-accelerating factor levels (CD55.5069.9.3) |
2e-42 |
rs12023811 |
1 |
GCST90240777 |
no MR -> candidate analysis |
| CD55 protein levels |
1e-37 |
rs1546430 |
4 |
GCST90468637 |
no MR -> candidate analysis |
| CR1 protein levels |
1e-23 |
rs549101507 |
5 |
GCST90468851 |
no MR -> candidate analysis |
| Complement receptor type 1 levels |
3e-19 |
rs72757638 |
1 |
GCST90247167 |
no MR -> candidate analysis |
| ADAMTS16 protein levels |
7e-18 |
rs547625232 |
1 |
GCST90468224 |
no MR -> candidate analysis |
| Complement decay-accelerating factor levels |
8e-18 |
rs116059019 |
1 |
GCST90426224 |
no MR -> candidate analysis |
| Myopia |
7e-14 |
rs28738985 |
1 |
GCST90134549 |
no MR -> candidate analysis |
| Age-related eyesight deterioration (confirmatory factor anal |
2e-13 |
rs28738985 |
1 |
GCST90309361 |
no MR -> candidate analysis |
| …and 18 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 682 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| refractive error |
0.609 |
— |
common-variant locus |
no MR -> candidate analysis |
| myopia |
0.58 |
— |
common-variant locus |
no MR -> candidate analysis |
| Hypermetropia |
0.544 |
— |
common-variant locus |
no MR -> candidate analysis |
| diverticular disease |
0.532 |
— |
common-variant locus |
MR: beta=0.111, p=0.00139 (cis) |
| macular degeneration |
0.521 |
— |
common-variant locus |
no MR -> candidate analysis |
| cervical carcinoma |
0.417 |
— |
common-variant locus |
no MR -> candidate analysis |
| Venous thrombosis |
0.425 |
— |
common-variant locus |
no MR -> candidate analysis |
| Progressive visual loss |
0.428 |
— |
common-variant locus |
no MR -> candidate analysis |
| hemorrhoid |
0.425 |
— |
common-variant locus |
no MR -> candidate analysis |
| Abnormality of refraction |
0.421 |
— |
common-variant locus |
no MR -> candidate analysis |
| age-related macular degeneration |
0.396 |
— |
common-variant locus |
no MR -> candidate analysis |
| primary angle-closure glaucoma |
0.403 |
— |
common-variant locus |
no MR -> candidate analysis |
| retinal detachment |
0.328 |
— |
common-variant locus |
MR: beta=0.246, p=0.00112 (cis) |
| retinal perforation |
0.328 |
— |
common-variant locus |
no MR -> candidate analysis |
| dental caries |
0.327 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 15 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Complement decay-accelerating factor) |
| gnomAD constraint |
pLI=3.9e-13, LOEUF=1.16 — LoF-tolerant |
| GWAS Catalog |
78 unique SNPs / 142 rows |
| ClinVar |
313 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 682 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘CD55’ and resolved to ‘Complement decay-accelerating factor’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 313 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 30 traits by best p-value, aggregated from 53 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P08174 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000196352/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4879428/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/CD55 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CD55 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CD55%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CD55 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:43:32 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none