CausalSentinel

Protein Dossier — CD5L (CD5 antigen-like)

MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).

1. Published MR estimates (retrieved, not computed)

Outcome	beta	se	p	method	nSNP	cis/trans	coloc
Non-cancer illness code self-reported: diverticular disease or diverticulitis	0.215	0.0665	0.00124	Wald ratio	1	cis	NA
Large vessel disease	-0.338	0.122	0.00557	Wald ratio	1	cis	NA
Ischemic stroke	-0.152	0.0575	0.00828	Wald ratio	1	cis	NA
Neuroblastoma	-0.379	0.154	0.0139	Wald ratio	1	cis	NA
Non-cancer illness code self-reported: osteoarthritis	-0.0767	0.0314	0.0144	Wald ratio	1	cis	NA
Diagnoses - main ICD10: B37 Candidiasis	0.588	0.247	0.0171	Wald ratio	1	cis	NA
Depressive symptoms	-0.0246	0.0105	0.0196	Wald ratio	1	cis	NA
Non-cancer illness code self-reported: hyperthyroidism or thyrotoxicosis	-0.33	0.144	0.0217	Wald ratio	1	cis	NA
Total cholesterol	-0.0414	0.0182	0.0233	Wald ratio	1	cis	NA
Diagnoses - main ICD10: C61 Malignant neoplasm of prostate	0.195	0.0883	0.0273	Wald ratio	1	cis	NA
Heel bone mineral density (BMD) T-score automated	0.0241	0.0112	0.0315	Wald ratio	1	cis	NA
Small vessel disease	-0.261	0.129	0.0435	Wald ratio	1	cis	NA
…and 89 more outcomes (see JSON)

2. pQTL instrument availability (Tier-B probe)

Dataset	Trait	Author	Year
prot-c-3293_2_4	CD5L	Suhre K	2019

3. GWAS Catalog results — traits with signal at this locus

62 association rows across 29 traits (56 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.

Trait	best p	lead SNP	n assoc	study	MR status
CD5L protein levels	3e-193	rs2765501	5	GCST90468640	no MR -> candidate analysis
CD5 antigen-like levels	2e-166	rs2765501	5	GCST90246946	no MR -> candidate analysis
FCRL3 protein levels	7e-144	rs11264843	17	GCST90469207	no MR -> candidate analysis
Hematological traits (multi-trait analysis)	2e-91	rs2765496	3	GCST90838667	no MR -> candidate analysis
Circulating FCRL3 levels	7e-83	rs112278796	1	GCST90860213	no MR -> candidate analysis
Blood protein levels	2e-82	rs2765496	4	GCST006585	no MR -> candidate analysis
Neutrophil count	1e-59	rs927698	1	GCST90101731	no MR -> candidate analysis
Serum levels of protein FCRL1	5e-59	rs2777817	1	GCST90089174	no MR -> candidate analysis
White blood cell count	5e-49	rs927698	1	GCST90101726	no MR -> candidate analysis
FCRL1 protein levels	2e-32	rs4971116	5	GCST90469205	no MR -> candidate analysis
C1QA protein levels	4e-30	rs2765501	1	GCST90468485	no MR -> candidate analysis
Serum levels of protein CD5L	2e-24	rs2765501	1	GCST90088295	no MR -> candidate analysis
…and 17 more traits (see JSON)

4. Phenome map — where this gene is a genetic locus, vs. where MR exists

Top diseases by Open Targets association (of 537 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.

Disease	genetic assoc.	burden (ExWAS)	causal status	MR status
functional neutrophil defect	0.572	—	common-variant locus	no MR -> candidate analysis
Dysmetria	0.35	—	common-variant locus	no MR -> candidate analysis

Of the 2 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.

5. Downstream annotation (druggability & safety preview)

Layer	Result
ChEMBL druggability	not available — no ChEMBL target (undrugged)
gnomAD constraint	pLI=2.6e-13, LOEUF=1.25 — LoF-tolerant
GWAS Catalog	100 unique SNPs / 180 rows
ClinVar	63 records; 2 pathogenic in sample of 30
PharmGKB/ClinPGx	no annotations

Caveats declared by the tools

• phenome — Top 30 of 537 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.
• chembl — No ChEMBL target for ‘CD5L’.
• clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 63 ClinVar records for this gene; it is a sample, not a rate.
• pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).
• gwas_traits — Top 20 of 29 traits by best p-value, aggregated from 62 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.

Sources

• uniprot: https://www.uniprot.org/uniprotkb/O43866 — UniProt release 2026_02 (10-June-2026)
• mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0
• phenome: https://platform.opentargets.org/target/ENSG00000073754/associations — Open Targets data release 26.06
• gnomad: https://gnomad.broadinstitute.org/gene/CD5L — gnomAD constraint via GraphQL API (reference genome GRCh38)
• gwas: https://www.ebi.ac.uk/gwas/genes/CD5L — GWAS Catalog REST (live; release not exposed by this endpoint)
• clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CD5L%5Bgene%5D — ClinVar build Build260809-1055.1
• gwas_traits: https://www.ebi.ac.uk/gwas/genes/CD5L — GWAS Catalog search API (live; release not exposed)

Provenance

• Generated: 2026-08-14T01:44:00 · Tier: A
• Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
• MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
• Tool errors this run: none

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