MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Diagnoses - main ICD10: D12 Benign neoplasm of colon rectum anus and anal canal | 0.462 | 0.0904 | 3.16e-07 | Wald ratio | 1 | cis | NA |
| Lung adenocarcinoma | -0.623 | 0.205 | 0.00238 | Wald ratio | 1 | cis | NA |
| Knee osteoarthritis | -0.479 | 0.182 | 0.00863 | Wald ratio | 1 | cis | NA |
| Lung cancer | -0.295 | 0.127 | 0.0203 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: vitiligo | 1.04 | 0.449 | 0.021 | Wald ratio | 1 | cis | NA |
| Paget’s disease | -0.89 | 0.403 | 0.0272 | Wald ratio | 1 | cis | NA |
| Knee and hip osteoarthritis | -0.324 | 0.148 | 0.0286 | Wald ratio | 1 | cis | NA |
| Heel bone mineral density (BMD) T-score automated | -0.0395 | 0.0217 | 0.0689 | Wald ratio | 1 | cis | NA |
| Pancreatic cancer | -0.596 | 0.328 | 0.0691 | Wald ratio | 1 | cis | NA |
| Vascular or heart problems diagnosed by doctor: Angina | -0.216 | 0.119 | 0.0696 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: osteoporosis | -0.368 | 0.205 | 0.0732 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: C61 Malignant neoplasm of prostate | 0.277 | 0.162 | 0.0869 | Wald ratio | 1 | cis | NA |
| …and 78 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
44 association rows across 26 traits (36 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating CDCP1 levels | 6e-461 | rs62244475 | 9 | GCST90859836 | no MR -> candidate analysis |
| CDCP1/MSR1 protein level ratio | 4e-358 | rs62244470 | 1 | GCST90313938 | no MR -> candidate analysis |
| CDCP1/IL18BP protein level ratio | 7e-328 | rs62244470 | 1 | GCST90313937 | no MR -> candidate analysis |
| CDCP1 protein levels | 1e-136 | rs79885994 | 6 | GCST90468667 | no MR -> candidate analysis |
| CUB domain-containing protein 1 levels | 5e-96 | rs2276862 | 3 | GCST90274775 | no MR -> candidate analysis |
| Tetranectin levels | 5e-66 | rs10514712 | 1 | GCST90249808 | no MR -> candidate analysis |
| Exosome complex component RRP43 levels | 1e-47 | rs149457742 | 1 | GCST90249380 | no MR -> candidate analysis |
| CUB domain-containing protein 1 (analyte X16818.200) levels | 4e-42 | rs72865129 | 1 | GCST90422872 | no MR -> candidate analysis |
| Macular thickness | 3e-30 | rs73089379 | 1 | GCST006976 | no MR -> candidate analysis |
| Macrophage inflammatory protein 1b levels | 1e-28 | rs62242542 | 1 | GCST004433 | no MR -> candidate analysis |
| CUB domain-containing protein 1 (analyte X6565.68) levels | 2e-27 | rs58868809 | 1 | GCST90426769 | no MR -> candidate analysis |
| Cerebrospinal fluid protein CDCP1 levels | 2e-27 | rs58868809 | 1 | GCST90943172 | no MR -> candidate analysis |
| …and 14 more traits (see JSON) |
Top diseases by Open Targets association (of 266 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| bone Paget disease | 0.59 | — | common-variant locus | no MR -> candidate analysis |
| nutritional deficiency disease | 0.466 | — | common-variant locus | no MR -> candidate analysis |
| arthropathy | 0.461 | — | common-variant locus | no MR -> candidate analysis |
| exostosis | 0.356 | — | common-variant locus | no MR -> candidate analysis |
| otosalpingitis | 0.282 | — | common-variant locus | no MR -> candidate analysis |
| Blocked Eustachian tube | 0.282 | — | common-variant locus | no MR -> candidate analysis |
Of the 6 rows above, 6 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.0021, LOEUF=0.657 — LoF-tolerant |
| GWAS Catalog | 61 unique SNPs / 122 rows |
| ClinVar | 141 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 266 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CDCP1’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 141 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 26 traits by best p-value, aggregated from 44 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9H5V8 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000163814/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CDCP1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CDCP1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CDCP1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CDCP1 — GWAS Catalog search API (live; release not exposed)