MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Alcohol intake frequency | -0.0228 | 0.00704 | 0.00118 | Wald ratio | 1 | cis | NA |
| Creatinine (enzymatic) in urine | -0.0115 | 0.00456 | 0.0117 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities | -0.0902 | 0.0364 | 0.0132 | Wald ratio | 1 | cis | NA |
| Systolic blood pressure automated reading | 0.0113 | 0.00488 | 0.0205 | Wald ratio | 1 | cis | NA |
| Eye problems or disorders: Diabetes related eye disease | 0.123 | 0.054 | 0.0227 | Wald ratio | 1 | cis | NA |
| Vascular or heart problems diagnosed by doctor: Angina | -0.064 | 0.0285 | 0.0246 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I48 Atrial fibrillation and flutter | -0.103 | 0.0501 | 0.0406 | Wald ratio | 1 | cis | NA |
| Diastolic blood pressure automated reading | 0.00999 | 0.00488 | 0.0406 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: C50 Malignant neoplasm of breast | 0.0706 | 0.0347 | 0.0421 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M16 Coxarthrosis [arthrosis of hip] | 0.0735 | 0.0369 | 0.0462 | Wald ratio | 1 | cis | NA |
| Lung cancer | -0.0664 | 0.0345 | 0.0541 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: depression | -0.0391 | 0.0204 | 0.0556 | Wald ratio | 1 | cis | NA |
| …and 86 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
74 association rows across 56 traits (60 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Serum levels of protein CDH11 | 1e-197 | rs3785315 | 2 | GCST90090775 | no MR -> candidate analysis |
| Blood protein levels | 3e-101 | rs59614634 | 1 | GCST006585 | no MR -> candidate analysis |
| Height | 7e-61 | rs35184 | 3 | GCST90245848 | no MR -> candidate analysis |
| Cadherin-11 level in Chronic kidney disease with hypertensio | 3e-43 | rs1130821 | 1 | GCST90239421 | no MR -> candidate analysis |
| Vertex-wise sulcal depth | 1e-39 | rs12920174 | 1 | GCST90095129 | no MR -> candidate analysis |
| Type 2 lactosamine alpha-2,3-sialyltransferase protein level | 4e-20 | rs12597175 | 1 | GCST90439315 | no MR -> candidate analysis |
| Vertex-wise cortical surface area | 2e-19 | rs257341 | 1 | GCST90095130 | no MR -> candidate analysis |
| Cortical surface area | 1e-17 | rs257341 | 2 | GCST90091060 | no MR -> candidate analysis |
| Primary open angle glaucoma (MTAG) | 6e-17 | rs257336 | 1 | GCST90310210 | no MR -> candidate analysis |
| Intraocular pressure | 2e-15 | rs564626594 | 6 | GCST005580 | no MR -> candidate analysis |
| Whole brain restricted directional diffusion (multivariate a | 5e-15 | rs1520229 | 1 | GCST90131905 | no MR -> candidate analysis |
| Cortical thickness | 6e-15 | rs257341 | 1 | GCST90091061 | no MR -> candidate analysis |
| …and 44 more traits (see JSON) |
Top diseases by Open Targets association (of 449 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Teebi hypertelorism syndrome 2 | 0.909 | — | established (curated) | no MR -> candidate analysis |
| Elsahy-Waters syndrome | 0.783 | — | established (curated) | no MR -> candidate analysis |
| Branchio-skeleto-genital syndrome | 0.608 | — | established (curated) | no MR -> candidate analysis |
| open-angle glaucoma | 0.784 | — | common-variant locus | no MR -> candidate analysis |
| chronic obstructive pulmonary disease | 0.559 | — | common-variant locus | no MR -> candidate analysis |
| atrial fibrillation | 0.51 | — | common-variant locus | MR: beta=-0.103, p=0.0406 (cis) |
| preeclampsia | 0.523 | — | common-variant locus | no MR -> candidate analysis |
| glaucoma | 0.524 | — | common-variant locus | no MR -> candidate analysis |
| prostatitis | 0.523 | — | common-variant locus | no MR -> candidate analysis |
| cervical carcinoma | 0.513 | — | common-variant locus | no MR -> candidate analysis |
Of the 10 rows above, 9 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Cadherin-11) |
| gnomAD constraint | pLI=1, LOEUF=0.268 — LoF-INTOLERANT |
| GWAS Catalog | 69 unique SNPs / 131 rows |
| ClinVar | 216 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 449 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘CDH11’ and resolved to ‘Cadherin-11’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 216 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 56 traits by best p-value, aggregated from 74 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P55287 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000140937/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2163173/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/CDH11 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CDH11 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CDH11%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CDH11 — GWAS Catalog search API (live; release not exposed)