MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Non-cancer illness code self-reported: high cholesterol | -0.182 | 0.038 | 1.72e-06 | Wald ratio | 1 | trans | NA |
| Forced expiratory volume in 1-second (FEV1) | 0.0393 | 0.0101 | 1.04e-04 | Wald ratio | 1 | trans | NA |
| Forced vital capacity (FVC) | 0.0342 | 0.00959 | 3.57e-04 | Wald ratio | 1 | trans | NA |
| Systolic blood pressure automated reading | -0.0393 | 0.012 | 0.00102 | Wald ratio | 1 | trans | NA |
| Body mass index (BMI) | -0.0345 | 0.0117 | 0.00313 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: hypertension | -0.0526 | 0.021 | 0.0123 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: R10 Abdominal and pelvic pain | -0.168 | 0.0671 | 0.0125 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: I48 Atrial fibrillation and flutter | 0.219 | 0.0898 | 0.0148 | Wald ratio | 1 | trans | NA |
| Bulimia nervosa | -0.0817 | 0.0337 | 0.0152 | Wald ratio | 1 | trans | NA |
| Endometrioid ovarian cancer | -0.349 | 0.145 | 0.0158 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: emphysema or chronic bronchitis | -0.325 | 0.144 | 0.0236 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: C50 Malignant neoplasm of breast | -0.269 | 0.122 | 0.027 | Wald ratio | 1 | trans | NA |
| …and 65 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
524 association rows across 276 traits (344 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| HSBP1 protein levels | 5e-307 | rs692603 | 29 | GCST90469481 | no MR -> candidate analysis |
| Bone mineral density mean | 1e-300 | rs758925805 | 6 | GCST90321120 | no MR -> candidate analysis |
| Adiponectin levels | 6e-270 | rs12051272 | 13 | GCST90662862 | no MR -> candidate analysis |
| BRK1 protein levels | 2e-118 | rs707236 | 4 | GCST90468469 | no MR -> candidate analysis |
| Adiponectin levels (BMI-adjusted) | 2e-68 | rs12051272 | 2 | GCST90011881 | no MR -> candidate analysis |
| Pulse pressure | 2e-67 | rs7500448 | 14 | GCST90310296 | no MR -> candidate analysis |
| ADIPOQ protein levels | 7e-39 | rs12051272 | 2 | GCST90468245 | no MR -> candidate analysis |
| WASHC3 protein levels | 2e-35 | rs707236 | 1 | GCST90471069 | no MR -> candidate analysis |
| Core binding factor acute myeloid leukemia | 4e-26 | rs4782534; rs1489313 | 2 | GCST008413 | no MR -> candidate analysis |
| Coronary atherosclerosis (PheCode 411.4) | 7e-25 | rs7500448 | 2 | GCST90475936 | no MR -> candidate analysis |
| Educational attainment | 8e-25 | rs8044562 | 11 | GCST90105038 | no MR -> candidate analysis |
| F-fish liking (derived food-liking factor) | 3e-24 | rs11859365 | 1 | GCST90094762 | no MR -> candidate analysis |
| …and 264 more traits (see JSON) |
Top diseases by Open Targets association (of 553 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| obesity disorder | 0.758 | — | common-variant locus | no MR -> candidate analysis |
| smoking initiation | 0.743 | — | common-variant locus | no MR -> candidate analysis |
| placenta praevia | 0.694 | — | common-variant locus | no MR -> candidate analysis |
| coronary artery disorder | 0.635 | — | common-variant locus | no MR -> candidate analysis |
| Alzheimer disease | 0.622 | — | common-variant locus | no MR -> candidate analysis |
| attention deficit-hyperactivity disorder | 0.603 | — | common-variant locus | no MR -> candidate analysis |
| atrial fibrillation | 0.625 | — | common-variant locus | MR: beta=0.219, p=0.0148 (trans) |
| hypertensive disorder | 0.609 | — | common-variant locus | no MR -> candidate analysis |
| myocardial ischemia | 0.616 | — | common-variant locus | no MR -> candidate analysis |
| coronary atherosclerosis | 0.607 | — | common-variant locus | no MR -> candidate analysis |
| substance abuse | 0.603 | — | common-variant locus | no MR -> candidate analysis |
| angina pectoris | 0.592 | — | common-variant locus | no MR -> candidate analysis |
| cervical carcinoma | 0.579 | — | common-variant locus | no MR -> candidate analysis |
| cardiovascular disorder | 0.573 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.581 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.85, LOEUF=0.529 — LoF-tolerant |
| GWAS Catalog | 252 unique SNPs / 646 rows |
| ClinVar | 326 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | 1 clinical annotations across 1 drugs |
phenome — Top 30 of 553 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CDH13’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 326 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 276 traits by best p-value, aggregated from 524 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P55290 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000140945/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CDH13 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CDH13 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CDH13%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=CDH13 — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/CDH13 — GWAS Catalog search API (live; release not exposed)