MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Non-cancer illness code self-reported: hypopituitarism | 0.777 | 0.278 | 0.00516 | Wald ratio | 1 | trans | NA |
| Internalizing problems | -0.264 | 0.0964 | 0.00627 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: high cholesterol | 0.0654 | 0.0257 | 0.0111 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] | 0.151 | 0.0632 | 0.0172 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: polio or poliomyelitis | 0.518 | 0.249 | 0.0376 | Wald ratio | 1 | trans | NA |
| Creatinine (enzymatic) in urine | 0.0193 | 0.00972 | 0.047 | Wald ratio | 1 | trans | NA |
| Cigarettes smoked per day | 0.669 | 0.355 | 0.0595 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities | -0.154 | 0.0834 | 0.0647 | Wald ratio | 1 | trans | NA |
| Clear cell ovarian cancer | 0.321 | 0.174 | 0.0655 | Wald ratio | 1 | trans | NA |
| Hippocampus volume | 37 | 20.1 | 0.0657 | Wald ratio | 1 | trans | NA |
| Forced vital capacity (FVC) | -0.0152 | 0.00834 | 0.0676 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: I48 Atrial fibrillation and flutter | 0.151 | 0.0834 | 0.0703 | Wald ratio | 1 | trans | NA |
| …and 90 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
78 association rows across 57 traits (56 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Body mass index | 3e-30 | rs8092156 | 15 | GCST90662912 | no MR -> candidate analysis |
| Weight | 1e-25 | rs2276191 | 2 | GCST90662910 | MR: beta=0.0111, p=0.479 (trans) |
| Weight (maximum, inv-normal transformed) | 2e-19 | rs7243232 | 1 | GCST90480726 | no MR -> candidate analysis |
| Body mass index (BMI, maximum, inv-normal transformed) | 3e-18 | rs874767 | 1 | GCST90479521 | no MR -> candidate analysis |
| Weight (mean, inv-normal transformed) | 8e-18 | rs2096944 | 1 | GCST90480727 | no MR -> candidate analysis |
| GLIPR1 protein levels | 1e-17 | rs565067589 | 1 | GCST90469357 | no MR -> candidate analysis |
| Body mass index (MTAG) | 7e-17 | rs2012927 | 1 | GCST90179150 | no MR -> candidate analysis |
| Body mass index (BMI, mean, inv-normal transformed) | 8e-17 | rs7243232 | 1 | GCST90479522 | no MR -> candidate analysis |
| Highest math class taken (MTAG) | 7e-15 | rs17075438 | 1 | GCST006568 | no MR -> candidate analysis |
| Type 2 diabetes | 7e-15 | rs35419009 | 3 | GCST90492734 | MR: beta=0.0382, p=0.433 (trans) |
| Personality traits or cognitive traits (multivariate analysi | 8e-15 | rs1994229 | 1 | GCST90270074 | no MR -> candidate analysis |
| Self-reported math ability (MTAG) | 1e-13 | rs72944032 | 1 | GCST006569 | no MR -> candidate analysis |
| …and 45 more traits (see JSON) |
Top diseases by Open Targets association (of 451 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| obesity disorder | 0.798 | — | common-variant locus | no MR -> candidate analysis |
| Irritability | 0.746 | — | common-variant locus | no MR -> candidate analysis |
| type 2 diabetes mellitus | 0.746 | — | common-variant locus | no MR -> candidate analysis |
| overnutrition | 0.717 | — | common-variant locus | no MR -> candidate analysis |
| mathematical ability | 0.713 | — | common-variant locus | no MR -> candidate analysis |
| diabetes mellitus | 0.622 | — | common-variant locus | no MR -> candidate analysis |
| diabetic neuropathy | 0.525 | — | common-variant locus | no MR -> candidate analysis |
| response to antihypertensive drug | 0.51 | — | common-variant locus | no MR -> candidate analysis |
| idiopathic pulmonary fibrosis | 0.419 | — | common-variant locus | no MR -> candidate analysis |
| myeloid leukemia | 0.396 | — | common-variant locus | no MR -> candidate analysis |
| gallbladder disorder | 0.382 | — | common-variant locus | no MR -> candidate analysis |
| smoking initiation | 0.37 | — | common-variant locus | no MR -> candidate analysis |
| Graves disease | 0.354 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of refraction | 0.349 | — | common-variant locus | no MR -> candidate analysis |
| color vision disorder | 0.346 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.99, LOEUF=0.486 — LoF-INTOLERANT |
| GWAS Catalog | 58 unique SNPs / 115 rows |
| ClinVar | 260 records; 6 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 451 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CDH7’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 260 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 57 traits by best p-value, aggregated from 78 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9ULB5 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000081138/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CDH7 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CDH7 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CDH7%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CDH7 — GWAS Catalog search API (live; release not exposed)